Publications
2023
Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients
Kumar Sharma,
Guanshi Zhang,
Jens Hansen,
Petter Bjornstad,
Hak Joo Lee,
Rajasree Menon,
Leila Hejazi,
Jian-Jun Liu,
Anthony Franzone,
Helen C Looker,
Byeong Yeob Choi,
Roman Fernandez,
Manjeri A Venkatachalam,
Luxcia Kugathasan,
Vikas S Sridhar,
Loki Natarajan,
Jing Zhang,
Varun S Sharma,
Brian Kwan,
Sushrut S Waikar,
Jonathan Himmelfarb,
Katherine R Tuttle,
Bryan Kestenbaum,
Tobias Fuhrer,
Harold I Feldman,
Ian H de Boer,
Fabio C Tucci,
John Sedor,
Hiddo Lambers Heerspink,
Jennifer Schaub,
Edgar A Otto,
Jeffrey B Hodgin,
Matthias Kretzler,
Christopher R Anderton,
Theodore Alexandrov,
David Cherney,
Su Chi Lim,
Robert G Nelson,
Jonathan Gelfond,
Ravi Iyengar,
Kidney Precision Medicine Project.
J Clin Invest. 2023 Oct 16;133(20):e170341. doi: 10.1172/JCI170341.
2023
Pharmacological perturbation of the phase-separating protein SMNDC1
Lennart Enders,
Marton Siklos,
Jan Borggräfe,
Stefan Gaussmann,
Anna Koren,
Monika Malik,
Tatjana Tomek,
Michael Schuster,
Jiří Reiniš,
Elisa Hahn,
Andrea Rukavina,
Andreas Reicher,
Tamara Casteels,
Christoph Bock,
Georg E Winter,
J Thomas Hannich,
Michael Sattler,
Stefan Kubicek.
Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0.
2023
Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
Irfete S Fetahu,
Wolfgang Esser-Skala,
Rohit Dnyansagar,
Samuel Sindelar,
Fikret Rifatbegovic,
Andrea Bileck,
Lukas Skos,
Eva Bozsaky,
Daria Lazic,
Lisa Shaw,
Marcus Tötzl,
Dora Tarlungeanu,
Marie Bernkopf,
Magdalena Rados,
Wolfgang Weninger,
Eleni M Tomazou,
Christoph Bock,
Christopher Gerner,
Ruth Ladenstein,
Matthias Farlik,
Nikolaus Fortelny,
Sabine Taschner-Mandl.
Nat Commun. 2023 Jun 26;14(1):3620. doi: 10.1038/s41467-023-39210-0.
2023
Buffy coat signatures of breast cancer risk in a prospective cohort study
Felicia Fei-Lei Chung,
Sandra González Maldonado,
Amelie Nemc,
Liacine Bouaoun,
Vincent Cahais,
Cyrille Cuenin,
Aurelie Salle,
Theron Johnson,
Bekir Ergüner,
Marina Laplana,
Paul Datlinger,
Jana Jeschke,
Elisabete Weiderpass,
Vessela Kristensen,
Suzette Delaloge,
François Fuks,
Angela Risch,
Akram Ghantous,
Christoph Plass,
Christoph Bock,
Rudolf Kaaks,
Zdenko Herceg.
Clin Epigenetics. 2023 Jun 12;15(1):102. doi: 10.1186/s13148-023-01509-6.
2023
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Thomas Krausgruber,
Anna Redl,
Daniele Barreca,
Konstantin Doberer,
Daria Romanovskaia,
Lina Dobnikar,
Maria Guarini,
Luisa Unterluggauer,
Lisa Kleissl,
Denise Atzmüller,
Carolina Mayerhofer,
Aglaja Kopf,
Simona Saluzzo,
Clarice X Lim,
Praveen Rexie,
Thomas Weichhart,
Christoph Bock,
Georg Stary.
Immunity. 2023 Feb 14;56(2):289-306.e7. doi: 10.1016/j.immuni.2023.01.014. Epub 2023 Feb 6.
2023
LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data
Peter Peneder,
Christoph Bock,
Eleni M Tomazou.
Bioinform Adv. 2022 Mar 23;2(1):vbac017. doi: 10.1093/bioadv/vbac017. eCollection 2022.
2023
Epigenetic regulation of T cell lineages in skin and blood following hematopoietic stem cell transplantation
Ram Vinay Pandey,
Johanna Strobl,
Anna Redl,
Luisa Unterluggauer,
Laura Gail,
Lisa Kleissl,
Sophie Müller,
Denise Atzmüller,
Victoria Fife-Gernedl,
Thomas Krausgruber,
Hanna Knaus,
Margit Mitterbauer,
Philipp Wohlfarth,
Werner Rabitsch,
Christoph Bock,
Georg Stary.
Clin Immunol. 2023 Mar;248:109245. doi: 10.1016/j.clim.2023.109245. Epub 2023 Jan 23.
2023
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Johanna Klughammer,
Daria Romanovskaia,
Amelie Nemc,
Annika Posautz,
Charlotte A Seid,
Linda C Schuster,
Melissa C Keinath,
Juan Sebastian Lugo Ramos,
Lindsay Kosack,
Ann Evankow,
Dieter Printz,
Stefanie Kirchberger,
Bekir Ergüner,
Paul Datlinger,
Nikolaus Fortelny,
Christian Schmidl,
Matthias Farlik,
Kaja Skjærven,
Andreas Bergthaler,
Miriam Liedvogel,
Denise Thaller,
Pamela A Burger,
Marcela Hermann,
Martin Distel,
Daniel L Distel,
Anna Kübber-Heiss,
Christoph Bock.
Nat Commun. 2023 Jan 16;14(1):232. doi: 10.1038/s41467-022-34828-y.
2023
The 2000HIV study: Design, multi-omics methods and participant characteristics
Wilhelm A J W Vos,
Albert L Groenendijk,
Marc J T Blaauw,
Louise E van Eekeren,
Adriana Navas,
Maartje C P Cleophas,
Nadira Vadaq,
Vasiliki Matzaraki,
Jéssica C Dos Santos,
Elise M G Meeder,
Janeri Fröberg,
Gert Weijers,
Yue Zhang,
Jingyuan Fu,
Rob Ter Horst,
Christoph Bock,
Rainer Knoll,
Anna C Aschenbrenner,
Joachim Schultze,
Linos Vanderkerckhove,
Talent Hwandih,
Elizabeth R Wonderlich,
Sai V Vemula,
Mike van der Kolk,
Sterre C P de Vet,
Willem L Blok,
Kees Brinkman,
Casper Rokx,
Arnt F A Schellekens,
Quirijn de Mast,
Leo A B Joosten,
Marvin A H Berrevoets,
Janneke E Stalenhoef,
Annelies Verbon,
Jan van Lunzen,
Mihai G Netea,
Andre J A M van der Ven.
Front Immunol. 2022 Dec 20;13:982746. doi: 10.3389/fimmu.2022.982746. eCollection 2022.
2022
Stress signaling boosts interferon-induced gene transcription in macrophages
Laura Boccuni,
Elke Podgorschek,
Moritz Schmiedeberg,
Ekaterini Platanitis,
Peter Traxler,
Philipp Fischer,
Alessia Schirripa,
Philipp Novoszel,
Angel R Nebreda,
J Simon C Arthur,
Nikolaus Fortelny,
Matthias Farlik,
Veronika Sexl,
Christoph Bock,
Maria Sibilia,
Pavel Kovarik,
Mathias Müller,
Thomas Decker.
Sci Signal. 2022 Dec 13;15(764):eabq5389. doi: 10.1126/scisignal.abq5389. Epub 2022 Dec 13.
