2020
Human recombinant soluble ACE2 in severe COVID-19.
Zoufaly A,
Poglitsch M,
Aberle JH,
Hoepler W,
Seitz T,
Traugott M,
Grieb A,
Pawelka E,
Laferl H,
Wenisch C,
Neuhold S,
Haider D,
Stiasny K,
Bergthaler A,
Puchhammer-Stoeckl E,
Mirazimi A,
Montserrat N,
Zhang H,
Slutsky AS,
Penninger JM.
Lancet Respir Med. 2020 Nov;8(11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. Epub 2020 Sep 24. Erratum in: Lancet Respir Med. 2020 Nov;8(11):e78.
2020
Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
Lercher A,
Popa AM,
Viczenczova C,
Kosack L,
Klavins K,
Agerer B,
Opitz CA,
Lanz TV,
Platten M,
Bergthaler A.
PLoS Pathog. 2020 Oct 12;16(10):e1008973. doi: 10.1371/journal.ppat.1008973.
2020
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS,
Vogel A,
Lercher A,
Caldera M,
Korosec A,
Pühringer M,
Hofmann M,
Hajto A,
Kieler M,
Garrido LQ,
Kerndl M,
Kuttke M,
Mesteri I,
Górna MW,
Kulik M,
Dominiak PM,
Brandon AE,
Estevez E,
Egan CL,
Gruber F,
Schweiger M,
Menche J,
Bergthaler A,
Weichhart T,
Klavins K,
Febbraio MA,
Sharif O,
Schabbauer G.
Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16.
2020
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2.
Popa A,
Genger JW,
Nicholson MD,
Penz T,
Schmid D,
Aberle SW,
Agerer B,
Lercher A,
Endler L,
Colaço H,
Smyth M,
Schuster M,
Grau ML,
Martínez-Jiménez F,
Pich O,
Borena W,
Pawelka E,
Keszei Z,
Senekowitsch M,
Laine J,
Aberle JH,
Redlberger-Fritz M,
Karolyi M,
Zoufaly A,
Maritschnik S,
Borkovec M,
Hufnagl P,
Nairz M,
Weiss G,
Wolfinger MT,
von Laer D,
Superti-Furga G,
Lopez-Bigas N,
Puchhammer-Stöckl E,
Allerberger F,
Michor F,
Bock C,
Bergthaler A.
Sci Transl Med. 2020 Dec 9;12(573):eabe2555. doi: 10.1126/scitranslmed.abe2555. Epub 2020 Nov 23.
2020
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import.
Girardi E,
Agrimi G,
Goldmann U,
Fiume G,
Lindinger S,
Sedlyarov V,
Srndic I,
Gürtl B,
Agerer B,
Kartnig F,
Scarcia P,
Di Noia MA,
Liñeiro E,
Rebsamen M,
Wiedmer T,
Bergthaler A,
Palmieri L,
Superti-Furga G.
Nat Commun. 2020 Dec 1;11(1):6145. doi: 10.1038/s41467-020-19871-x.
2020
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.
Alm E,
Broberg EK,
Connor T,
Hodcroft EB,
Komissarov AB,
Maurer-Stroh S,
Melidou A,
Neher RA,
O'Toole A,
Pereyaslov D,
WHO European Region sequencing laboratories and GISAID EpiCoV group; WHO European Region sequencing laboratories and GISAID EpiCoV group*.
Euro Surveill. 2020 Aug;25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
2020
Structural cells are key regulators of organ-specific immune responses.
Krausgruber T,
Fortelny N,
Fife-Gernedl V,
Senekowitsch M,
Schuster LC,
Lercher A,
Nemc A,
Schmidl C,
Rendeiro AF,
Bergthaler A,
Bock C.
Nature. 2020 Jul;583(7815):296-302. doi: 10.1038/s41586-020-2424-4. Epub 2020 Jul 1.
2020
Environmental arginine controls multinuclear giant cell metabolism and formation.
Brunner JS,
Vulliard L,
Hofmann M,
Kieler M,
Lercher A,
Vogel A,
Russier M,
Brüggenthies JB,
Kerndl M,
Saferding V,
Niederreiter B,
Junza A,
Frauenstein A,
Scholtysek C,
Mikami Y,
Klavins K,
Krönke G,
Bergthaler A,
O'Shea JJ,
Weichhart T,
Meissner F,
Smolen JS,
Cheng P,
Yanes O,
Menche J,
Murray PJ,
Sharif O,
Blüml S,
Schabbauer G.
Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1.
2020
Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation.
Wilson JL,
Nägele T,
Linke M,
Demel F,
Fritsch SD,
Mayr HK,
Cai Z,
Katholnig K,
Sun X,
Fragner L,
Miller A,
Haschemi A,
Popa A,
Bergthaler A,
Hengstschläger M,
Weichhart T,
Weckwerth W.
Cell Rep. 2020 Feb 4;30(5):1542-1552.e7. doi: 10.1016/j.celrep.2020.01.011.
2020
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network.
van den Hoogen B,
Santoni A,
Sciumé G,
Bowie A,
O'Farrelly C,
O'Neill L,
Anthonsen M,
Pardali K,
Young S,
Bergthaler A,
Manel N,
Zahn R,
Kikkert M,
Snijder E,
van Kuppeveld F,
Fouchier R,
Hiscott J.
Virus Res. 2020 Oct 2;287:198094. doi: 10.1016/j.virusres.2020.198094. Epub 2020 Jul 28.
