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2019

Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle.

Göschl L, Winkler S, Dmytrus J, Heredia RJ, Lagler H, Ramharter M, Scheinecker C, Bonelli M, Schmetterer K, Pickl WF, Grabmeier-Pfistershammer K, Hershfield MS, Boztug K, Förster-Waldl E, Gualdoni GA.
J Clin Immunol. 2019 Nov 4. doi: 10.1007/s10875-019-00700-w.
2019

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

Kiss MG, Ozsvár-Kozma M, Porsch F, Göderle L, Papac-Miličević N, Bartolini-Gritti B, Tsiantoulas D, Pickering MC, Binder CJ.
 Front Immunol. 2019;10:1607. Published 2019 Jul 11. doi:10.3389/fimmu.2019.01607
2019

Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.

Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T.
 JCI Insight. 2019;4(20):e124164. Published 2019 Oct 17. doi:10.1172/jci.insight.124164
2019

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease.

Houben T, Magro Dos Reis I, Oligschlaeger Y, Steinbusch H, Gijbels MJJ, Hendrikx T, Binder CJ, Cassiman D, Westerterp M, Prickaerts J, Shiri-Sverdlov R.
Front Immunol. 2019 Jan 7;9:3089. doi: 10.3389/fimmu.2018.03089. eCollection 2018.
2019

Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis.

Halbritter F, Farlik M, Schwentner R, Jug G, Fortelny N, Schnöller T, Pisa H, Schuster LC, Reinprecht A, Czech T, Gojo J, Holter W, Minkov M, Bauer W, Simonitsch-Klupp I, Bock C, Hutter C.
Cancer Discov. 2019 Oct;9(10):1406-1421. doi: 10.1158/2159-8290.CD-19-0138.
2019

Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants [published online ahead of print, 2019 Nov 21].

Korchynska S, Krassnitzer M, Malenczyk K, Prasad RB, Tretiakov EO, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger SN, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak DD, Romanov RA, Pifl C, Groop L, Hökfelt TG, Harkany T.
 EMBO J. 2019;e100882. doi:10.15252/embj.2018100882
2019

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA.
Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001.
2019

Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells.

Muller A, Gasch J, Albring KF, Aberger F, Nivarthi H, Khemeri M, Moriggl R, Friedrich KH.
Neoplasma. 2019 May 23;66(3):357-366. doi: 10.4149/neo_2018_180731N560.
2019

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells.

Piper CJM, Rosser EC, Oleinika K, Nistala K, Krausgruber T, Rendeiro AF, Banos A, Drozdov I, Villa M, Thomson S, Xanthou G, Bock C, Stockinger B, Mauri C.
 Cell Rep. 2019;29(7):1878–1892.e7. doi:10.1016/j.celrep.2019.10.018
2019

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.

Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N.
Nat Immunol. 2019 Nov;20(11):1435-1443. doi: 10.1038/s41590-019-0493-z.