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2026

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

Irene Schwartz, Valentina Budroni, Mathilde Meyenberg, Zuzana Hodakova, Harald Hornegger, Kathrin Hacker, Siegfried Schwartz, Daniel B Grabarczyk, Julian F Ehrmann, Sara Scinicariello, David Haselbach, Jörg Menche, Tim Clausen, G Elif Karagöz, Gijs A Versteeg.
Nat Commun. 2026 Jan 19;17(1):1723. doi: 10.1038/s41467-026-68420-5.
2026

What are the limits to biomedical research acceleration through general-purpose AI?

Konstantin Hebenstreit, Constantin Convalexius, Stephan Reichl, Stefan Huber, Christoph Bock, Matthias Samwald.
Sci Rep. 2026 Jan 12;16(1):1304. doi: 10.1038/s41598-025-32583-w.
2026

KRAS mutated lung adenocarcinoma responds to pan-ERBB and Aurora kinase inhibitors

Iris Z Uras, Marija V Trkulja, Abdelrahman K A A Salama, Jaqueline Horvath, Khushi Asnani, Christoph Trenk, Stefan Kubicek, Martin Bilban, Herwig P Moll, Emilio Casanova.
NPJ Precis Oncol. 2026 Jan 12;10(1):14. doi: 10.1038/s41698-025-01242-8.
2026

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

M Leone, N Kinz, F Eichin, D Obwegs, V C Sladky, V Z Braun, R Hirschberger, D Rizzotto, L Englmaier, C Manzl, K Moos, J Mergner, P Giansanti, N Martinez-Garcia, M M Marques, E D Jacotot, L Eblahed, R Yousif, M K Wright, D Dawood, L S Maupome, C Savko, M Boerries, M A Sussman, A Villunger.
Cell Death Differ. 2026 Jun;33(6):1292-1304. doi: 10.1038/s41418-025-01645-x. Epub 2026 Jan 12.
2026

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3

Elisabeth Hennes, Belén Lucas, Natalie S Scholes, Xiu-Fen Cheng, Daniel C Scott, Matthias Bischoff, Katharina Reich, Raphael Gasper, María Lucas, Teng Teng Xu, Sofia Rossini, Lisa-Marie Pulvermacher, Lara Dötsch, Hana Imrichova, Alexandra Brause, Siska Führer, Kesava Reddy Naredla, Sonja Sievers, Kamal Kumar, Petra Janning, Ciriana Orabona, Malte Gersch, Peter J Murray, Brenda A Schulman, Georg E Winter, Slava Ziegler, Herbert Waldmann.
Nat Chem. 2026 Mar;18(3):585-596. doi: 10.1038/s41557-025-02021-5. Epub 2026 Jan 7.
2026

Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis

Katharina Hoppe, Johannes Woelk, Julia Benz, Sarah Spoeck, William J Olson, Andreas Villunger, Natascha Hermann-Kleiter, Verena Labi.
FEBS J. 2026 May;293(10):2845-2861. doi: 10.1111/febs.70387. Epub 2026 Jan 6.
2026

Mitotic errors as triggers of cell death and inflammation

Dario Rizzotto, Christian Zierhut, Andreas Villunger.
Nat Cell Biol. 2026 Jan;28(1):21-34. doi: 10.1038/s41556-025-01785-9. Epub 2026 Jan 6.
2025

Editorial: Extracellular Matrix Biomarkers Illuminate the Architecture of Portal Hypertension in End-Stage Liver Disease-Authors' Reply

Mattias Mandorfer, Benedikt Simbrunner, Diana Julie Leeming.
Aliment Pharmacol Ther. 2026 Mar;63(5):743-744. doi: 10.1111/apt.70499. Epub 2025 Dec 21.
2025

Type I interferon at the crossroads of metastatic dissemination

Teresa Neuwirth, Barbara B Maier.
Nat Rev Immunol. 2026 Feb;26(2):87. doi: 10.1038/s41577-025-01259-x.
2025

Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain

Sabrina Grundtner, Feng Xian, Daniel Malzl, Tina Radits, Allison Marie Barry, Julia Regina Sondermann, Jörg Menche, David Gómez-Varela, Manuela Schmidt.
Biomed Pharmacother. 2025 Dec;193:118855. doi: 10.1016/j.biopha.2025.118855. Epub 2025 Dec 4.