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2021

Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.

Shahin T, Kuehn HS, Shoeb MR, Gawriyski L, Giuliani S, Repiscak P, Hoeger B, Yüce Petronczki O, Köstel Bal S, Zoghi S, Dmytrus J, Seruggia D, Castanon I, Rezaei N, Varjosalo M, Halbritter F, Rosenzweig SD, Boztug K.
Sci Immunol. 2021 Nov 26;6(65):eabe3981. doi: 10.1126/sciimmunol.abe3981. Epub 2021 Nov 26.
2021

Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin- and mucosa-resident memory T cells.

Saluzzo S, Pandey RV, Gail LM, Dingelmaier-Hovorka R, Kleissl L, Shaw L, Reininger B, Atzmüller D, Strobl J, Touzeau-Römer V, Beer A, Staud C, Rieger A, Farlik M, Weninger W, Stingl G, Stary G.
Immunity. 2021 Dec 14;54(12):2842-2858.e5. doi: 10.1016/j.immuni.2021.10.021. Epub 2021 Nov 22.
2021

SARS-CoV-2 infection and replication in human gastric organoids.

Giobbe G.
Nat Commun. 2021 Nov 16;12(1):6610. doi: 10.1038/s41467-021-26762-2.
2021

Molecular characterization of Barrett's esophagus at single-cell resolution

Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2113061118. doi: 10.1073/pnas.2113061118.
2021

A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses.

Beumer J.
Nat Commun. 2021 Sep 17;12(1):5498. doi: 10.1038/s41467-021-25729-7.
2021

Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis.

Obermayer G, Afonyushkin T, Göderle L, Puhm F, Schrottmaier W, Taqi S, Schwameis M, Ay C, Pabinger I, Jilma B, Assinger A, Mackman N, Binder C.
Blood
2021

Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity.

Haimel H, Pazmandi J, Jiménez Heredia R, Dmytrus J, Köstel Bal S, Zoghi S, van Daele P, Briggs TA, Wouters C, Bader-Meunier B, Aeschlimann FA, Caorsi R, Eleftheriou D, Hoppenreijs E, Salzer E, Bakhtiar S, Derfalvi B, Saettini F, Kusters MAA, Elfeky R, Trück J, Rivière JQ, van der Burg M, Gattorno M, Seidel MG, Burns S, Warnatz K, Hauck F, Brogan P, Gilmour KC, Schuetz C, Simon A, Bock C, Hambleton S, de Vries E, Robinson PN, van Gijn M, Boztug K.
J Allergy Clin Immunol
2021

Network analysis reveals rare disease signatures across multiple levels of biological organization.

Buphamalai P, Kokotovic T, Nagy V, Menche J.
Nat Commun. 2021 Nov 9;12(1):6306. doi: 10.1038/s41467-021-26674-1.
2021

The interplay of immunology and cachexia in infection and cancer.

Baazim H, Antonio-Herrera L, Bergthaler A.
Nat Rev Immunol. 2021 Oct 4;1-13. doi: 10.1038/s41577-021-00624-w.
2021

Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing.

Datlinger P, Rendeiro AF, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C.
Nat Methods