Publications
2026
Metabolic reprogramming drives pancreatic β cell neogenesis from α cells
Yufeng Zhang,
Guangxing Lu,
Wenhao Xie,
Peng Xu,
Cenxi Liu,
Olga Babosova,
Jamie Christopher Reilly,
Zhehui Li,
Leshi Chen,
Liying Zhou,
Jing Gao,
Lennart Enders,
Xuelian Xiong,
Mingyu Li,
Stefan Kubicek,
Bing Zhao,
Zhe Feng,
Biao Yu,
Lu Zhou,
He Huang,
Jin Li.
Nat Chem Biol. 2026 Aug 7. doi: 10.1038/s41589-026-02293-z. Online ahead of print.
2026
Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response
Anne-Sophie M C Marques,
Ludwig G Bauer,
Tuan-Anh Nguyen,
Alejandro Gonzalez Orta,
Jan-Lennart Venne,
Carol Cheng,
Esra Balıkçı,
Yusi Liu,
Barr Tivon,
Alena Kroupova,
Alessio Ciulli,
Nir London,
Stefan Kubicek,
Kilian V M Huber.
Nat Commun. 2026 Jun 30;17(1):8192. doi: 10.1038/s41467-026-74489-9.
2026
Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss
Jessica Kalla,
Thomas Dillinger,
Zlata Pavlovicova,
Reema Jacob,
Emine Atas,
Katarina Mišura,
Anil Baskan,
Kristina Draganić,
Andreas Tiefenbacher,
Tanja Limberger,
Theresia Mair,
Gabriel Wasinger,
Ludovica Villanti,
Stefan Kubicek,
Lukas Kenner,
Gerda Egger.
Cell Rep Methods. 2026 Apr 20;6(4):101370. doi: 10.1016/j.crmeth.2026.101370. Epub 2026 Mar 30.
2026
KRAS mutated lung adenocarcinoma responds to pan-ERBB and Aurora kinase inhibitors
Iris Z Uras,
Marija V Trkulja,
Abdelrahman K A A Salama,
Jaqueline Horvath,
Khushi Asnani,
Christoph Trenk,
Stefan Kubicek,
Martin Bilban,
Herwig P Moll,
Emilio Casanova.
NPJ Precis Oncol. 2026 Jan 12;10(1):14. doi: 10.1038/s41698-025-01242-8.
2025
Inhibitors supercharge kinase turnover through native proteolytic circuits
Natalie S Scholes,
Martino Bertoni,
Arnau Comajuncosa-Creus,
Katharina Kladnik,
Xuefei Guo,
Fabian Frommelt,
Matthias Hinterndorfer,
Hlib Razumkov,
Polina Prokofeva,
Martin P Schwalm,
Florian Born,
Sandra Roehm,
Hana Imrichova,
Brianda L Santini,
Eleonora Barone,
Caroline Schätz,
Miquel Muñoz I Ordoño,
Severin Lechner,
Andrea Rukavina,
Iciar Serrano,
Miriam Abele,
Anna Koren,
Stefan Kubicek,
Stefan Knapp,
Nathanael S Gray,
Giulio Superti-Furga,
Bernhard Kuster,
Yigong Shi,
Patrick Aloy,
Georg E Winter.
Nature. 2026 Jan;649(8098):1032-1041. doi: 10.1038/s41586-025-09763-9. Epub 2025 Nov 26.
2025
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Tuan-Anh Nguyen,
Jung-Ming G Lin,
Anne-Sophie M C Marques,
Maximilian Fottner,
Ludwig G Bauer,
Andreas Reicher,
Diana Daum,
Lorenzo Scrofani,
Yusi Liu,
Carol Cheng,
Luna D'Angelo L D D,
Juan Sanchez,
Christoph Bueschl,
Nara Marella,
Pisanu Buphamalai,
Florian Traversi,
Maša Bereš,
Herwig P Moll,
Marton Siklos,
Jakob-Wendelin Genger,
Gerald Hofstaetter,
Ludovica Villanti,
Monika Malik,
Christoph Klimek,
Kathrin Runggatscher,
Bettina Guertl,
Jesper S Hansen,
Sarah Dobner,
Olga Babosova,
Tina Becirovic,
Laura P M H de Rooij,
Emilio Casanova,
Anna Koren,
D Sean Froese,
David S Rosenblatt,
Kristaps Klavins,
Andreas Bergthaler,
Jörg Menche,
J Thomas Hannich,
Miriam Abele,
Sara Sdelci,
Kathrin Lang,
Kilian V M Huber,
Stefan Kubicek.
Science. 2025 Dec 11;390(6778):1143-1150. doi: 10.1126/science.adv4257. Epub 2025 Nov 6.
2025
The human proteome with direct physical access to DNA
Jakob Trendel,
Simon Trendel,
Shuyao Sha,
Franziska Greulich,
Sandra Goll,
Susanne I Wudy,
Karin Kleigrewe,
Stefan Kubicek,
N Henriette Uhlenhaut,
Bernhard Kuster.
Cell. 2025 Aug 7;188(16):4424-4440.e17. doi: 10.1016/j.cell.2025.04.037. Epub 2025 May 22.
2024
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis
Laura Gebetsberger,
Zahra Malekshahi,
Aron Teutsch,
Gabor Tajti,
Frédéric Fontaine,
Nara Marella,
André Mueller,
Lena Prantl,
Hannes Stockinger,
Heribert Stoiber,
Anna Ohradanova-Repic.
Emerg Microbes Infect. 2024 Dec;13(1):2417868. doi: 10.1080/22221751.2024.2417868. Epub 2024 Oct 28.
2024
Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection
Katja Knapp,
Romana Klasinc,
Anna Koren,
Magdalena Siller,
Ruth Dingelmaier-Hovorka,
Mathias Drach,
Juan Sanchez,
David Chromy,
Marlene Kranawetter,
Christoph Grimm,
Andreas Bergthaler,
Stefan Kubicek,
Hannes Stockinger,
Georg Stary.
Cell Rep Med. 2024 Jul 16;5(7):101643. doi: 10.1016/j.xcrm.2024.101643. Epub 2024 Jul 8.
2024
Monitoring subcellular protein localization at scale in live cells
Jiří Reiniš,
Andreas Reicher.
Nat Rev Mol Cell Biol. 2024 Sep;25(9):673. doi: 10.1038/s41580-024-00749-5.
