CD Laboratory for Chemical Epigenetics and Antiinfectives
Point of Contact: Pinpointing Small Molecule-Protein Binding
ExTrAct AML - Linking ex-vivo chemosensitivity, treatment and pathway activations for a deeper understanding of pediatric AML
Microbiomes Drive Planetary Health
Brain Resilience
Regulation of cell death decisions
The role of tRNA thiolation in human disease
PROMISE: Personalized Therapy for Immune-linked Disorders
HAVOC - Human avatar on chip for advancing personalized cancer therapies by integrating vascular and immune components in a Tumor-on-Chip model
Transporter Map
Traumatoids: Modeling traumatic brain injury with organoids
Gut-immune-brain axis dysfunction in premature neonates
Dissecting Cell Type-specific Chromatin Dynamics Driven by Oncogenic JAK-STAT Signalling
HDACs as regulators of T cell-mediated immunity in health and disease
Chemical probing and functional characterization of the E3 substrate receptor DCAF15
The targeted degradation of proteins is of utmost importance for the well-being of our cells and thus for the entire organism. Damaged proteins must be recognized and removed to prevent collateral damage. In addition, proteins must be removed in a targeted manner in order to allow the activation, but also the deactivation of cellular signal transduction pathways. Defects in the targeted degradation of proteins can result in diseases such as cancer and neurodegeneration.
The Special Research Program, SFB F79, is funded by the Austrian Science Fund (FWF) with contributions by the German Research Foundation (DFG).
The collaborative research program includes scientists from Max Perutz Labs, University of Vienna, Medical University of Vienna, CeMM, GMI, IMBA and IMP from Vienna as well as IMB in Mainz, who have joined forces to discover mechanism of targeted protein degradation, and how this process can be manipulated.
METALGATES - Transporters as mediators of metal toxicity
Mechanisms of protein degradation via hydrophobic tagging
Enhancing T cell immunity in tumor-draining lymph nodes
Circulating Endothelial Cells as Vascular Aging Sensors
Visual Proteomics for studying subcellular protein dynamics
Nuclear One Carbon Metabolism
Chemical hijacking KRAS-driven proteolytic networks
Transcriptional regulation of human gastric cell types
MOTION - Mechanisms in pOrtal hyperTensION / DISEASE-DRIVING MECHANISM IN PATIENTS WITH PORTAL HYPERTENSION
LBI Institute for Network Medicine
Innovative chemistry library to probe biology
LiquidBiopsyKids: Validation of a liquid biopsy based molecular diagnostic toolkit for pediatric sarcomas
PREDICTOME: Precision medicine for breast cancer: multi-omics towards predicting complete remission and avoiding surgery
Mechanistic target elucidation by systematic stochastic tagging of antiproliferative compounds
ReprogrammAR: Chemical Reprogramming of Autophagy Receptors
mlDIAMANT: machine learning decodes interaction archetypes of memrane proteins to predict the effect of genetic variants
Multiscale discovery of cellular and microanatomical determinants of metastasis
