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Open Positions
01 August 2025 Master Student in Tumor Immunology (m/f/d) Part-time employee, Vienna #Life sciences #Applied biology #PCR Analysis #Biology laboratory Show details 01 July 2025 Senior Scientist, Biology for AITHYRA (m/f/d) Full-time employee, Vienna #Applied research #Life sciences #Applied biology
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Allcyte (part of Exscientia)
Allcyte (part of Exscientia) The biotech start-up company Allcyte focuses on functional drug testing in primary human material. With the so-called “Pharmacoscopy” high-content imaging platform, Allcyte (now Exscientia) supports pre-clinical drug development and clinical decision making services by h
/business-opportunities/tech-transfer/spin-offs/allcyte/
Abdel Rahman Abdel Fattah Funding
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Postdoc Open Day 2025
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Michael Häupl
Politician
Dr. Michael Häupl © Michael Sazel Mayor of Vienna "As mayor of the City of Vienna I am very proud of the Center of Molecular Medicine because it is one outstanding research institution out of a large number of top scientific institutes based in our city. I personally congratulate Professor Superti-F
/about-cemm/arts-and-society/supporters/research-report-2007/michael-haeupl/
Peter Schuster
Scientist
Prof. Dr. Peter Schuster © Michael Sazel President of the Austrian Academy of Science "The goal of CeMM is to perform cutting-edge research and to break a path towards a new kind of medicine that takes advantage of the large body of knowledge from present day life sciences for diagnostic, preventive
/about-cemm/arts-and-society/supporters/research-report-2007/peter-schuster/
Wolfgang Schütz
Scientist
Prof. Dr. Wolfgang Schütz © Michael Sazel Rector, Medical University of Vienna "It is a pleasure to congratulate the Center of Molecular Medicine CeMM for its first research report. The Medical University of Vienna supports and fosters CeMM as an important project together with the Austrian Academy
/about-cemm/arts-and-society/supporters/research-report-2007/wolfgang-schuetz/
Johannes Hahn
Politician
Dr. Johannes Hahn © Michael Sazel Federal Minister for Science and Research "It is a pleasure for me to accompany the first Research Report of the Center of Molecular Medicine (CeMM) of the Austrian Academy of Science with my best wishes and some introducing words. For our Government Science and Res
/about-cemm/arts-and-society/supporters/research-report-2007/johannes-hahn/
Heinz Fischer
President
Dr. Heinz Fischer President of the Austrian Republic "Discovery is based on curiosity and execution of ideas. It is satisfactory to see ideas turn into reality. The idea behind the Center of Molecular Medicine was to bring science and medicine close together and allow young scientists and medical do
/about-cemm/arts-and-society/supporters/research-report-2007/heinz-fischer/
Ursula Schmidt-Erfurth
Physician
Prof. Dr. Ursula Schmidt-Erfurth © Michael Sazel Head of the Department of Ophthalmology and Optometrics at the Medical University of Vienna, Vienna General Hospital "The cooperation between several departments at the Medical University of Vienna and CeMM is working perfectly well and already involv
/about-cemm/arts-and-society/supporters/research-report-2008/ursula-schmidt-erfurth/
Johanna Rachinger
Scientist
Dr. Johanna Rachinger © Michael Sazel Director General of the Austrian National Library, Member of the Senate of the Austrian Academy of Sciences “Knowledge and management of knowledge have been a historical treasure and tradition of Austria for centuries. The importance of the biomedical domain is
/about-cemm/arts-and-society/supporters/research-report-2008/johanna-rachinger/
Harald zur Hausen
Scientist
Prof. Dr. Harald zur Hausen © Dics Ringeisen & Schupp GBR Winner of the Nobel Prize for Medicine 2008 “I congratulate CeMM on the high quality of work going on in an area of research dear to me, at the intersection of infections, inflammation and cancer. I see the creation of CeMM as an impressive a
/about-cemm/arts-and-society/supporters/research-report-2008/harald-zur-hausen/
Hans Tuppy
Scientist
Prof. Dr. Hans Tuppy © Michael Sazel Chair of the Board of the University of Natural Resources and Applied Life Sciences Vienna, President of the Austrian Science Fund (1974–1982), Rector of the University of Vienna (1983–1985), President of the Austria Academy of Sciences (1985–1987), Minister for
/about-cemm/arts-and-society/supporters/research-report-2009/hans-tuppy/
Christoph Zielinski
Scientist
Prof. Dr. Christoph Zielinski © Michael Sazel Chairman, Department of Medicine I and Cancer Center, General Hospital – Medical University Vienna "CeMM is about to become one of the leading centers of applied basic research in the city of Vienna and beyond. With its major and important scientific con
/about-cemm/arts-and-society/supporters/research-report-2009/christoph-zielinski/
Bernd Binder
Scientist
Prof. Dr. Bernd Binder © Michael Sazel Department of Vascular Biology and Thrombosis Research, Medical University of Vienna "CeMM – just another research institution? No! CeMM was founded in close relation to the Medical University of Vienna to provide it with the unique opportunity of combining mos
/about-cemm/arts-and-society/supporters/research-report-2009/bernd-binder/
Helmut Gadner
Scientist
Prof. Dr. Helmut Gadner © Michael Sazel Director, St. Anna Children’s Cancer Research Institute "Molecular Biology is very central to many modern aspects of pediatrics, from diagnosis to therapy. At St. Anna, we have recently opened a new state-of-the-art research center with a special focus on the
/about-cemm/arts-and-society/supporters/research-report-2009/helmut-gadner/
Max L. Birnstiel
Scientist
Prof. Dr. Max L. Birnstiel © Alessandra Meier Founding Director of the Research Institute of Molecular Pathology (IMP) "From the publications in the last years it is clear that in the short time of its existence CeMM has initiated world class research in its chosen areas and is poised, if supported
/about-cemm/arts-and-society/supporters/research-report-2009/max-l-birnstiel/
Reinhard Krepler
AKH Director
Prof. Dr. Reinhard Krepler © Michael Sazel Director of the Vienna General Hospital (AKH) "CeMM has been a dear and important project for us. I am proud of the fact that the new CeMM building is currently under construction on the premises of the General Hospital and I am sure that under the leadersh
/about-cemm/arts-and-society/supporters/research-report-2009/reinhard-krepler/
Helga Nowotny
Scientist
Prof. Dr. Helga Nowotny, PhD © Michael Sazel Vice-President, European Research Council “More and better research is and should be a critical goal for Europe and its path into the future. The Center for Molecular Medicine of the Austrian Academy of Sciences is one of those institutions that contribut
/about-cemm/arts-and-society/supporters/research-report-2008/helga-nowotny/
Barbara Prammer
Politician
Mag.ª Barbara Prammer © Michael Sazel President of the Austrian National Council, Member of the Senate of the Austrian Academy of Sciences “I am personally interested in a strong and open relationship between civil society and scientific research. Therefore, I support this important institution of t
/about-cemm/arts-and-society/supporters/research-report-2008/barbara-prammer/
Monika Kircher-Kohl
CEO
Mag.ª Monika Kircher-Kohl © Daniel Raunig Chief Executive Officer, Infineon Technologies Austria AG “There is no stable economic development without research. Leading research institutions like CeMM provide important innovations driving technology-based businesses. Moreover, they play a fundamental
/about-cemm/arts-and-society/supporters/research-report-2008/monika-kircher-kohl/
Georg Stingl
Scientist
Prof. Dr. Georg Stingl © Michael Sazel President of the Section for Mathematics and the Natural Sciences of the Austrian Academy of Sciences "Exactly 30 years ago, the immunologist Dr. William Paul – at that time President of the ASCI – heralded the advent of a golden era of clinical investigation.
/about-cemm/arts-and-society/supporters/research-report-2010/georg-stingl/
Helmut Denk
Scientist
Prof. Dr. Helmut Denk © Michael Sazel President of the Austrian Academy of Sciences "I am proud to say that the Research Center for Molecular Medicine (CeMM) is one of the pearls in the research portfolio of the Austrian Academy of Sciences. ‘From bed to bench and back to bed’ can be regarded as the
/about-cemm/arts-and-society/supporters/research-report-2010/helmut-denk/
Christine Mannhalter
Scientist
Prof. Dr. Christine Mannhalter © Michael Sazel Molecular Diagnostics, Medical University Vienna, Vice President of the Austrian Science Fund "Knowing and understanding the pathological mechanisms of diseases is a central need of medical research and of key importance for all future diagnostic and th
/about-cemm/arts-and-society/supporters/research-report-2010/christine-mannhalter/
Karlheinz Töchterle
Politician
Prof. Dr. Karlheinz Töchterle © Michael Sazel Austria’s Federal Minister of Science and Research "As the famous roman playwright Terence let one of his characters say: ‘Nihil tam difficile est, quin quaerendo investigari possit.’ Nothing is so difficult that it cannot be found out by seeking. Surely
/about-cemm/arts-and-society/supporters/research-report-2011/karlheinz-toechterle/
Beatrix Karl
Politician
Dr. Beatrix Karl © Michael Sazel Austria’s Federal Minister of Science and Research "Despite the economic turmoil in the last years, the government has been able to still strengthen the financial support for Science in Austria. CeMM is one of the lightning towers in Austria devoted to close the gap
/about-cemm/arts-and-society/supporters/research-report-2010/beatrix-karl/
Benedikt and Beatrice Spiegelfeld
Sponsors
Dr. Benedikt and Beatrice Spiegelfeld © Michael Sazel Sponsors of the Constantin Spiegelfeld Lectures "With its reputation for scientific excellence and its prime location within the Vienna medical campus, CeMM provides the perfect framework for a popular lecture series aimed at raising awareness of
/about-cemm/arts-and-society/supporters/research-report-2010/benedikt-and-beatrice-spiegelfeld/
Brigitte Ederer
Siemens AG
Mag.ª Brigitte Ederer © Michael Sazel Member of the Executive Board of Siemens AG "When I was Vienna’s financial city counsellor, I remember vividly the initial discussions with Mayor Häupl and Academy President Welzig on the merit of starting an institute to tackle some of the research hurdles for
/about-cemm/arts-and-society/supporters/research-report-2010/brigitte-ederer/
Hannes Androsch
Entrepreneur
Dr. Hannes Androsch © Thomas Fröhle Chairman, Austrian Council for Research and Technology Development Senator, Austrian Academy of Sciences "Investment in education and research is critical for the progress of a modern and just society. The Austrian Academy of Sciences fulfils an important role in
/about-cemm/arts-and-society/supporters/research-report-2010/hannes-androsch/
Arnold Pollak
Physician
Prof. Dr. Arnold Pollak © Michael Sazel Head of the Department of Pediatrics and Adolescent Medicine, Medical University of Vienna "Pediatric research has a strong tradition in Vienna and the Pediatrics Department is very active in both research and clinical innovation. I am very happy that Kaan Boz
/about-cemm/arts-and-society/supporters/research-report-2011/arnold-pollak/
Andreas Mailath-Pokorny
Politician
Dr. Andreas Mailath-Pokorny © Michael Sazel City Councelor for Culture and Science, Vienna "I think there is a link between the science, art and society vocation of CeMM and its success. I’ve learned to know this leading Viennese institute as a mainspring for new concepts, and out-of-the-box thinkin
/about-cemm/arts-and-society/supporters/research-report-2011/andreas-mailath-pokorny/
Josef Penninger
Scientist
Prof. Dr. Josef Penninger © Michael Sazel Scientific Director, Institute of Molecular Biotechnology (IMBA) "I have followed the developments of CeMM from the outset. Under Giulio’s leadership, the CeMM has become a true world-class institute. For IMBA, to have the sister institution CeMM located clo
/about-cemm/arts-and-society/supporters/research-report-2011/josef-penninger/
Bernhard Felderer
Scientist
Prof. Dr. Bernhard Felderer © Michael Sazel Director, Institute for Advanced Studies, Vienna "For sure there is a correlation between vigorous investments in innovative research and the economic health of nations. This may become particularly important for health-related research in times of demogra
/about-cemm/arts-and-society/supporters/research-report-2011/bernhard-felderer/
Arts & Society
/about-cemm/arts-and-society/
Privacy Policy
Privacy Policy of CeMM CeMM complies with its legal information obligations regarding the protection of personal data with this privacy policy. The legal basis is primarily derived from the following regulations: General Data Protection Regulation (GDPR) – EU Regulation 2016/679 on the protection of
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Imprint
Media Owner Publisher CeMM Research Center for Molecular Medicine GmbH of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 1090 Vienna Austria Phone: +43-1/40160-70011 Fax: +43-1/40160-970 000 Email: office[at]cemm.oeaw.ac.at Website: www.cemm.at Executive Management Prof. Dr. Giulio S
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Jun Yang
Jun Yang © Michael Sazel Artist “What a great idea to have art in a research center! The brain lounge on top of the building: Think different, think out of the box, think utopian, and be visionary in order to find possible answers and new questions. Perhaps here the researchers and me being an artis
/about-cemm/arts-and-society/supporters/research-report-2024/jun-yang/
Abdel Rahman Abdel Fattah People
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Get in Touch
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Georg Busslinger Group
Research Focus Our research group focuses on the epithelial cell biology of human gastrointestinal organs, specifically the esophagus, stomach, and small intestine. These digestive organs perform specialized functions that work in concert to facilitate nutrient uptake and digestion. The esophagus tr
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Jürgen Knoblich
Professor Jürgen Knoblich © Michael Sazel Senior Principle Scientist, Institute of Molecular Biotechnology Austria (IMBA) of the Austrian Academy of Sciences, Vienna "CeMM is an important part of Austria’s research landscape. Personally, I have been following CeMM’s journey and development from its
/about-cemm/arts-and-society/supporters/research-report-2024/juergen-knoblich/
Eva Schernhammer
Professor Eva Schernhammer © Michael Sazel Department Head, Epidemiology, Medical University of Vienna "CeMM is where brilliant ideas caffeinate into discoveries in the heart of Vienna. With top researchers and an exceptional (and delightfully enthusiastic) international student body, they tackle to
/about-cemm/arts-and-society/supporters/research-report-2024/eva-schernhammer/
Marta Agostinho
Marta Agostinho, PhD © Bubu Dujmic EU-LIFE Executive Director, Barcelona "CeMM is a gem - an institute where outstanding science blooms out of generous doses of vision, passion and unwavering commitment. A founding partner of EU-LIFE, the alliance of leading research institutes in the life sciences
/about-cemm/arts-and-society/supporters/research-report-2024/marta-agostinho/
Michael Bronstein
Professor Michael Bronstein © Hans Leitner Scientific Director, AITHYRA of the Austrian Academy of Sciences, Vienna DeepMind Professor of AI at the University of Oxford "CeMM is an inspiration and a fountain of creative ideas in the Vienna biomedical scene. We are excited to have her as our OeAW sis
/about-cemm/arts-and-society/supporters/research-report-2024/michael-bronstein/
Martin Moder
Dr. Martin Moder © Michael Sazel Molecular Biologist, Member of the Science Busters CeMM Alumnus, Vienna "I have never seen so many intelligent, motivated people in one place. My project succeeded thanks to CeMM's excellent research infrastructure and, above all, seamless collaboration with colleagu
/about-cemm/arts-and-society/supporters/research-report-2024/martin-moder/
Mafalda Dias
Mafalda Dias, PhD © Bubu Dujmic Group Leader, Centre for Genomic Regulation (CRG), Barcelona "It was a pleasure to experience the energy of CeMM and reimagine the research institute of the future. I look forward to many visits to come, to strengthening the ties between CRG and CeMM, and to shaping s
/about-cemm/arts-and-society/supporters/research-report-2024/mafalda-dias/
Terrace Chairs
Thank you to the donors To replace the aging furniture on the terrace, CeMM started the fundraising campaign “One Chair One for CeMM”, in December 2020. We are very grateful to the sponsors for supporting the purchase of 48 inspirational and weatherproof chairs from the brand Magis. The improvement
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Christoph Bock Fellowships
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Location
CeMM is Embedded in the Campus of Vienna's Medical University and General Hospital Embedded in the campus of the Medical University of Vienna and Vienna General Hospital, Austria’s largest medical research complex, CeMM’s position promotes a close collaboration between basic researchers and clinicia
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Alumni Registration
Please fill in the registration form in order to join the CeMM Alumni Network.
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Facebook
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Linkedin
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Bluesky
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Inclusiveness & Diversity
Inclusiveness & Diversity Fostering a Welcoming Culture at CeMM CeMM offers a strong international research environment, shaped by the diverse cultural backgrounds of its employees. Workplace diversity is a clear advantage that fuels our successful scientific research, collaborative projects , and d
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Living in Vienna
Living in Vienna Top quality of life in Europe’s most livable city © C. Stemper / WienTourismus Looking for a city that combines world-class culture, exceptional quality of life, and everyday comfort? Welcome to Vienna , a city that consistently ranks as one of the best places to live in the world .
/join-cemm/life-at-cemm/living-in-vienna/
Press
PR Team The Public Relations & Communications team is your first contact for press/media enquiries and any general questions concerning CeMM. Visit our News section to read our press releases and articles. Please download our Press Kit here .
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Stefan Kubicek Fellowships
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Press Kit
Biosketches Giulio Superti-Furga, Scientific Director Download biosketch Download CV Press pictures Anita Ender, Administrative Director Anita Ender_1 (by Michael Sazel) Anita Ender_2 (by Klaus Pichler) Giulio Superti-Furga, Scientific Director Superti-Furga (by Franzi Kreis) Superti-Furga_1 (by Fra
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Miriam Unterlass Publications
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Miriam Unterlass Funding
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Miriam Unterlass People
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Davide Seruggia Group
Research Focus We are a team of molecular and computational biologists working at the interface of chromatin biology, genome editing, and cancer research. We are particularly interested in understanding fundamental aspects of gene regulation in the context of pediatric leukemia and other hematologic
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Georg Stary Group
Research Focus The research projects of Georg Stary focus on various aspects of host-pathogen interactions and the role of tissue-resident leukocytes in both physiological and pathological immune responses. Georg’s research interest lies in the biology, longevity, turnover, and function of tissue-re
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Miriam Unterlass Group
Research Focus The research interests of Miriam Unterlass focus on functional materials rich in aromatic and heterocyclic compounds. These structural features impart outstanding material properties such as high thermal stability, chemical resistance, and fluorescence. These materials show interestin
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Davide Seruggia Publications
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Georg Stary Publications
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Davide Seruggia People
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Georg Stary People
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Thomas Reiberger Group
Research Focus Thomas Reiberger is a physician scientist focusing on clinically-relevant research questions for patients with liver disease. His HEPEX lab investigates novel treatment strategies for liver fibrosis and portal hypertension targeting vascular abnormalities (Reiberger, Journal of Hepato
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Thomas Reiberger CD Lab for Portal Hypertension and Fibrosis in Liver Disease
CD Lab for Portal Hypertension and Fibrosis in Liver Disease The Christian Doppler Laboratory for Portal Hypertension and Fibrosis in Liver Disease is a public-private partnership between the Christian Doppler Research Association (CDG), the Medical University of Vienna, Boehringer Ingelheim, and th
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Jörg Menche Funding
Projects WWTF VRG15 Computational Biosciences Network Medicine - An interactome-based Approach to Rare Diseases Duration 2016 - 2024 Link to project WWTF LS16 Precision Medicine PrecisePID - Systems Precision Medicine of Inborn Errors of the Immune System Duration 2017 - 2020 Link to project MSCA In
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Thomas Reiberger Publications
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Jörg Menche Publications
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Thomas Reiberger People
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Jörg Menche People
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Jörg Menche Group
Research Focus Recent advances in high-throughput technologies have created exciting new opportunities for systematically investigating the molecular mechanisms underlying human disease. CeMM researchers employ a broad range of powerful post-genomic technologies, including next-generation sequencing
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Nuno Maulide Group
Research Focus The research of Nuno Maulide's group in organic chemistry has mostly focused on unusual or "unconventional" reactivity profiles of organic compounds. His group has taken particular interest in high-energy reactive intermediates that can be generated under mild conditions and subsequen
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Florian Grebien Publications
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Nuno Maulide Publications
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Nuno Maulide People
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Florian Grebien People
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Georg Busslinger Publications
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Georg Busslinger Fellowships
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Georg Busslinger Funding
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Georg Busslinger People
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Kaan Boztug Publications
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Kaan Boztug Funding
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Kaan Boztug People
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Andreas Bergthaler Group
Research Focus Our group explores how inflammatory processes are regulated and how the immune system responds to viral infections. Using well-defined mouse infection models and cell culture systems, combined with molecular techniques from immunology, virology, and systems biology, we aim to gain ins
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Andreas Bergthaler Publications
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Andreas Bergthaler People
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Giulio Superti-Furga Fellowships
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Giulio Superti-Furga Publications
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Giulio Superti-Furga Funding
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Giulio Superti-Furga People
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Laura de Rooij Publications
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Laura de Rooij Funding
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Laura de Rooij People
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Barbara Maier Group
Research Focus Tumor Immunology and the Tumor Microenvironment Our research group investigates the complex immune interactions within the tumor microenvironment (TME) of solid tumors, with a focus on mechanisms of immune suppression and tumor immune evasion. Our overarching goal is to overcome the c
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André Rendeiro Group
Research Focus Our research group focuses on spatial and computational biology to understand how cells interact to form complex human physiology—and how these interactions change over the human lifespan and contribute to disease. We develop and apply advanced computational methods for the analysis o
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Barbara Maier Publications
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André Rendeiro Publications
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Barbara Maier Funding
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Barbara Maier People
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Clarissa Campbell Group
Research Focus Our goal is to understand how immunity and metabolism are integrated at the organismal level. Adaptive lymphocytes of higher vertebrates play an essential role in immune responses and perform extensive accessory functions that contribute to tissue homeostasis. Although the fundamental
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Stefan Kubicek Group
Research Focus The Kubicek Laboratory works in the field of Chemical Epigenetics, aiming to discover, develop, and characterize small molecules that impact cellular identity. Cell type and cell fate decisions are controlled by chromatin pathways that work in close connection to cellular metabolism t
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Stefan Kubicek CD Lab for Chemical Epigenetics and Antiinfectives
The Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives was a public-private partnership between CeMM, Boehringer Ingelheim and Haplogen with the aim of developing novel screening technologies and identifying chemical probe compounds as a basis for future drug development projec
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Clarissa Campbell Publications
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Stefan Kubicek Publications
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Clarissa Campbell Funding
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Stefan Kubicek Funding
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Clarissa Campbell People
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Stefan Kubicek People
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André Rendeiro People
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Abdel Rahman Abdel Fattah Group
Research Focus Our group combines local active mechanical stimulation with readouts of cell-driven extracellular matrix (ECM) dynamics, using bioengineered stimulation tools, time-lapse microscopy, particle image velocimetry (PIV), image analysis, and simulations. Combined with longitudinal observat
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Christoph Bock Funding
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Christoph Bock Publications
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Christoph Bock People
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International Funding
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National Funding
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Fellowships
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July - Alex Lercher
Meet Alex Lercher Tell me in five words who is Alexander Lercher Curious, creative, cat-person, speedy, nerdy What made you join CeMM? I was truly impressed by the cutting-edge research of the individual labs at CeMM and even more so by CeMM’s super-collaborative spirit, which I think allows for mag
/join-cemm/alumni/alumni-of-the-month/2024/july-alex-lercher/
September - Federica Quattrone
Meet Federica Quattrone Tell me in five words who is Federica Quattrone? Vivacious, Adventurous, Poised, Self-willed, Optimist. What made you join CeMM? The reason why joining CeMM struck me at the end of the second exhausting day of PhD selection, while enjoying a glass of wine at the CeMM terrace
/join-cemm/alumni/alumni-of-the-month/2024/september-federica-quattrone/
August - Sarah Grosche
Meet Sarah Grosche Tell me in five words who is Sarah Grosche Curious scientist gone drug hunter. What made you join CeMM? After studying genomic alterations and their impact on diseases, I wanted to learn more about other layers of transcriptional regulation such as epigenetics and metabolism. Stef
/join-cemm/alumni/alumni-of-the-month/2024/august-sarah-grosche/
Upcoming Events
Monday 12 May 2025 - 06:00 PM 2025 Landsteiner Lecture Tony Wyss-Coray Join Tony Wyss-Coray on 12 May 2025 for the 2025 Landsteiner Lecture at the Austrian Academy of Sciences on blood-borne factors in brain aging, followed by music and a reception. Hosted by Giulio Superti-Furga.
/about-cemm/events/upcoming-events/
November - Ana Krolo
Meet Ana Krolo Tell me in five words who is Ana Krolo? Energetic, determined, caring, people loving, hardworking mom of two beautiful boys. What made you join CeMM? Upon completion of my experimental work, but not defending the thesis yet I started to look for positions in more translational setting
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April - Saara Inkinen
Meet Saara Inkinen Tell me in five words who is Saara Inkinen Innovative — resilient — optimist — goal-oriented — weightlifter What made you join CeMM? Before I joined CeMM in 2016, I held two thematically broad positions in Finland: I was responsible for the technology transfer activities of Åbo Ak
/join-cemm/alumni/alumni-of-the-month/2024/april-saara-inkinen/
March - Camilo Sanchez
Meet Camilo Sanchez Tell me in five words who is Camilo Sánchez? Curious, adventurous, caring, daring, Colombian. What made you join CeMM? I moved to Austria, and I was trying hard to land a job before my 6-month language course-visa expired. CeMM had an opening for a unique EU project were luckily
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October - Christoph Baumann
Meet Christoph Baumann 1. Tell me in 5 words who is Christoph Baumann? Curious, dedicated and ambitious entrepreneur 2. What made you join CeMM? In 2007 CeMM was a bit more than a handful of people with a big vision about being and building one of the best research institutes for translational scien
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May - Cecilia Domínguez Conde
Meet Cecilia Dominguez Conde Tell me in five words who is Cecilia Dominguez Conde Curious immunologist passionate about genomics. What made you join CeMM? Back in 2012, I was finishing my master’s degree at the Division of infection and immunity of University College London (UCL) and I was looking f
/join-cemm/alumni/alumni-of-the-month/2024/may-cecilia-dominguez-conde/
February - Lindsay Kosack
Meet Lindsay Kosack Tell me in five words who is Lindsay Kosack? World-citizen, optimist, hiker, surfer, introvert What made you join CeMM? I was actually in a somewhat desperate situation. I had finished my Bachelor and had 12 months work experience as a Research Assistant in Melbourne, when I deci
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December - Christopher Fell
Meet Christopher Fell 1. Tell me in five words who is Christopher Fell? Motivated, curious, chilled, unshelled, British. 2. What made you join CeMM? When I was looking for PhD positions, to be honest I did not have Vienna or CeMM on my radar. In the UK we often use www.findaphd.com , on which I stum
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June - Enrico Girardi
Meet Enrico Girardi Tell me in five words who is Enrico Girardi Curious, driven, nice, hardworking, book-loving What made you join CeMM? After a PhD and a postdoc in structural biology I became interested in systems and cellular biology - Giulio's lab was the perfect fit as it combines expertise in
/join-cemm/alumni/alumni-of-the-month/2024/june-enrico-girardi/
December - Joana Ferreira da Silva
Meet Joana Ferreira da Silva Tell me in five words who is Joana Ferreira da Silva? Portuguese scientist driven by questions What made you join CeMM? It was clear from the beginning that CeMM was a special place – unlike anything I had encountered before. I was immediately struck by its international
/join-cemm/alumni/alumni-of-the-month/2024/december-joana-ferreira-da-silva/
March - Dijana Vitko
Meet Dijana Vitko 1. Tell me in 5 words who is Dijana Vitko? Spontaneous, stubborn, curious, travel- and nature-enthusiast. 2. What made you join CeMM? I wanted to expand my analytical skills and apply these to biological and medically relevant questions. Ph.D. position in Mass Spectrometry & Proteo
/join-cemm/alumni/alumni-of-the-month/2023/march-dijana-vitko/
June - Andrea Majoros
Meet Andrea Majoros 1. Tell me in 5 words who is Andrea Majoros? That is a difficult question. (Ha, 5 words!). In adjectives: communicative, cooperative, curious, openhearted, friendly. In nouns: mum, scientist, hiker, team leader, mentor. 2. What made you join CeMM? During my interview I saw a PI w
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August - Angela Bauch
Meet Angela Bauch 1. Tell me in 5 words who is Angela Bauch? International, open-for-challenges, scientist, optimistic, ambitious. 2. What made you join CeMM? In the spring of 2004, Giulio introduced me to the inception of a new institute – CeMM, an interdisciplinary research institute in Vienna. Ha
/join-cemm/alumni/alumni-of-the-month/2023/august-angela-bauch/
July - Michal Schmida
Meet Michal Smida 1. Tell me in 5 words who is Michal Smida? Curious, optimistic, persistent, friendly, opened to anything new. 2. What made you join CeMM? A new Postdoctoral program was being opened at CeMM and when I came for the interview, it was just amazing – the spirit, the people, the buildin
/join-cemm/alumni/alumni-of-the-month/2023/july-michal-schmida/
April - Jacques Colinge
Meet Jacques Colinge 1. Tell me in 5 words who is Jacques Colinge? Computer scientist and mathematician interested in biology. 2. What made you join CeMM? My attraction for places in the making and the exceptional profile of Giulio Superti-Furga. I love building things from scratch. The potential to
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September - Donat Alpar
Meet Donat Alpar 1. Tell me in 5 words who is Donat Alpar? Oddball enjoying humor, freedom and challenges. 2. What made you join CeMM? In 2015, I was looking for a position specifically in Vienna and somehow spotted the attractive rooftop terrace of CeMM on the Google Maps. It was also encouraging h
/join-cemm/alumni/alumni-of-the-month/2023/september-donat-alpar/
January - Bernd Boidol
Meet Bernd Boidol Bernd Boidol, former PhD student in the group of CeMM Principal Investigator Stefan Kubicek. 1. Tell me in 5 words who is Bernd Boidol? Improvement junkie, biotech executive, dad (in ascending order of importance). 2. What made you join CeMM? CeMM has likely the best mix of a vigor
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February - Uwe Rix
Meet Uwe Rix Uwe Rix on the right side, former Postdoc in the group of CeMM Scientific Director Giulio Superti-Furga. 1. Tell me in 5 words who is Uwe Rix? Passionate, dedicated, curious, rational, perspicacious. 2. What made you join CeMM? My main motivations were to learn chemical proteomics and d
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May - Dimitris Tsiantoulas
Meet Dimitris Tsiantoulas Dimitris Tsiantoulas, former PhD student in the former group of CeMM Principal Investigator Christoph Binder. 1. Tell me in 5 words who is Dimitris Tsiantoulas? Dad, indefatigable, considerate, impatient, curious. 2. What made you join CeMM? When I met the people at CeMM, I
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April - Ana Pudja
Meet Ana Pudja 1. Tell me in 5 words who is Ana Pudja? Optimistic, Determined, Passionate, Learner, Mom of 3 adorable children. 2. What made you join CeMM? I have always been interested in medical research – the closer to patients the more motivating it was for me. It was a spark at first sight when
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March - Christian Schmidl
Meet Christian Schmidl Christian Schmidl, former Postdoc in the group of CeMM Principal Investigator Christoph Bock. 1. Tell me in 5 words who is Christian Schmidl? A “family-loving life-embracing science-preaching humorous individual”. 2. What made you join CeMM? After my PhD my wife and I went on
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September - Tea Pemovska
Meet Tea Pemovska 1. Tell me in 5 words who is Tea Pemovska? Passionate, determined, stubborn, impatient, and mom. 2. What made you join CeMM? I did my PhD at another EU-Life partner institute (FIMM - Institute for Molecular Medicine Finland and I very much liked the international, interactive, smal
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June - Matthias Brand
Meet Matthias Brand 1. Tell me in 5 words who is Matthias Brand? Scientist by day, boardgamer at night. Trying to find the fun in every aspect of life. People-centric. Fastidious. Unable to count to 5. 2. What made you join CeMM? I was keen on doing my PhD in a supportive and collaborative environme
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November - Barbara Mair
Meet Barbara Mair 1. Tell me in 5 words who is Barbara Mair? A curious, caring, determined, passionate sports enthusiast. 2. What made you join CeMM? After doing my diploma thesis in a very basic research oriented field, I was eager to move into a more translational science direction and was particu
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December - Nikolaus Fortelny
Meet Nikolaus Fortelny 1. Tell me in 5 words who is Nikolaus Fortelny? I try to “be like water, my friend”. 2. What made you join CeMM? Initially, a job advertisement, an opportunity to learn something new, and a good track record. During the interview, the perspective to do exciting research with s
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October - Hatoon Baazim
Meet Hatoon Baazim 1. Tell me in 5 words who is Hatoon Baazim? Arab-woman, scientist, artist, dancer, writer (when I push myself). 2. What made you join CeMM? CeMM was clearly different, I could see that from the moment I looked at the website and read the description of the PhD program application
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July - Astrid Fauster
Meet Astrid Fauster 1. Tell me in 5 words who is Astrid Fauster? A curious, caring, headstrong overthinker. 2. What made you join CeMM? I was intrigued by the translational focus - the aspect of doing science in close proximity to medical needs. 3. What is it about science that interests you the mos
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May - Evren Karayel
Meet Evren Karayel 1. Tell me in 5 words who is Evren Karayel? Curiosity, enthusiasm, eager to learn, arts, food. 2. What made you join CeMM? I met Giulio-Superti Furga and Tilmann Bürckstümmer in a selection committee for the PhD program “CCHD” of MedUni Vienna. I knew immediately that I wanted to
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December - Ana Zivkovic
Meet Ana Zivkovic 1. Tell me in 5 words who is Ana Zivkovic? Curious- Effective - Forward thinker- Problem Solver- Mother. 2. What made you join CeMM? I was deeply in the application process for PhD at University of Chicago in US in 2006, when an invite came for CeMM PhD program. I loved the enthusi
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June - Ferran Fece de la Cruz
Meet Ferran Fece de la Cruz Ferran Fece de la Cruz, former PhD in the group of former CeMM Principal Investigator Sebastian Nijman. 1. Tell me in 5 words who is Ferran Fece de la Cruz? Catalan, a freedom fighter, a dreamer, a traveler, a food lover. 2. What made you join CeMM? As any other millennia
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October - Maria Gorna
Meet Maria Gorna 1. Tell me in 5 words who is Maria Gorna? Science addict / Creative / Bubbly / Compassionate / Short memory. 2. What made you join CeMM? I had an opportunity to attend Sci Foo where I met Giulio. He charmed me with his passion and vision while I was already interested in his researc
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July - Tatjana Hirschmugl
Meet Tatjana Hirschmugl Tatjana Hirschmugl, former Technical Assistant in the group of CeMM Adjunct PI Kaan Boztug. 1. Tell me in 5 words who is Tatjana Hirschmugl? Impatient / Emotional / Eco-friendly / Creative / Self-critical 2. What made you join CeMM? An attractive job offer in an international
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February - Cristina Mayor Ruiz
Meet Cristina Mayor Ruiz 1. Tell me in 5 words who is Cristina Mayor Ruiz? Optimism, empathy, passion, impatience, running-lover. 2. What made you join CeMM? For my postdoc, I was interested in targeted protein degradation. I asked around and several colleagues recommended CeMM, so I applied to Geor
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January - André Rendeiro
Meet André Rendeiro 1. Tell me in 5 words who is André Rendeiro? Data wizard / Romantic / European / Creative / Yes we can. 2. What made you join CeMM? I have to admit that while I had been in Vienna prior to joining CeMM I had not heard about it, perhaps because I was not studying biomedicine but d
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September - Marco Licciardello
Meet Marco Licciardello Marco Licciardello, former PhD student in the group of CeMM PI Stefan Kubicek. 1. Tell me in 5 words who is Marco Licciardello? Curious, strong-willed, patient, witty, open-minded. 2. What made you join CeMM? Cancer has affected the lives of some of my closest family. At CeMM
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November - Ioannis Legouras
Meet Ioannis Legouras Ioannis Legouras, former scientific writer and scientific assistant to CeMM Scientific Director Giulio Superti-Furga. 1. Tell me in 5 words who is Ioannis Legouras? Passionate, curious, adaptive, persistent, international. 2. What made you join CeMM? After finishing my PhD at E
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S.M.A.R.T. Lectures
The S.M.A.R.T. lecture series addresses contemporary challenges of science in an interdisciplinary manner and at the interface of science & society. It aims to encourage out-of-the-box-thinking as well as to establish a dialogue with the broader public. The initiative of our young institute is dedic
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April - Christopher Schliehe
Meet Christopher Schliehe 1. Tell me in 5 words who is Christopher Schliehe? Creativity, curiosity, dedication, empathy, humor. 2. What made you join CeMM? My motivation to search for postdoc positions in Vienna was initially driven by personal reasons. One or two years before I joined CeMM, my girl
/join-cemm/alumni/alumni-of-the-month/2021/april-christopher-schliehe/
May - Katrin Ljunggren
Meet Kathrin Ljunggren Katrin Ljunggren, former PhD in the group of CeMM Scientific Director Giulio Superti-Furga. 1. Tell me in 5 words who is Kathrin Ljunggren? Contagious laughter, Vice President of the FC Bayern fan chapter, Non-scientific looks, R autodidact, Short curly hair – don't care. 2. W
/join-cemm/alumni/alumni-of-the-month/2021/may-katrin-ljunggren/
March - Adriana Gonçalves
Meet Adriana Gonçalves Adriana Gonçalves, former PhD student in the group of CeMM Scientific Director Giulio Superti-Furga. 1. Tell me in 5 words who is Adriana Gonçalves? #creativity #tolerance #wanderlust #science #motherhood 2. What made you join CeMM? I was one of the first PhD students to have
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Chemical Screening Facility
The Chemical Screening Facility at CeMM provides internal and external researchers, as well as commercial project partners, with access to advanced chemical biology resources. These include a 100+k compound library and state-of-the-art high-throughput and high-content screening technologies, enablin
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Alumni Network at CeMM
CeMM Alumni Network Stay Connected & Empower your Career Founded in 2017, the CeMM Alumni Network was created to connect, reconnect, and foster collaboration among former CeMM researchers and staff. Today, the network proudly includes over 200 alumnae and alumni worldwide, united by a shared commitm
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Denise P. Barlow
Description Genomic imprinting occurs when the expression of a gene is restricted to one of the two parental chromosomes in a diploid cell. Since the discovery of Denise Barlow and her team in 1991 of the first imprinted gene in mammals to show parental-specific gene expression and our later finding
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Publications
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Former Groups
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Vimeo
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Research Ethics
The role of laboratory animals for our research Diseases such as cancer or immune disorders are influenced by the interaction of different organs and cells. In molecular medicine, we try to understand just these complex interactions in the body and to develop approaches for new treatment methods. Si
/about-cemm/how-we-work/research-ethics/
Christoph Binder
Description Oxidation-specific epitopes in atherosclerosis During the development of atherosclerotic lesions, low-density lipoproteins (LDL) deposit in the wall of large and medium-sized arteries, where they become oxidized and are taken up by infiltrating macrophages resulting in the formation of f
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Management
Giulio Superti-Furga CEO and Scientific Director Giulio Superti-Furga, Ph.D., is Scientific Director and CEO of the Research Center of Molecular Medicine of the Austrian Academy of Sciences and Professor of Medical Systems Biology at the Center for Physiology Medical University of Vienna. He is also
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Administration
Admin Team Leaders (f.l.t.r.): Prudence Donovan, Jean-Paul Chidiac, Jan Leszczynski, Robert Kuntner, Anita Ender, Marc Wiedner, Anton Peisser, Mischa Pilz, Anna Wolfschwenger CeMM’s Administration and Scientific Support team understands that an ever-improving technical, operational, educational, fin
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B-PCG Reports
View Bundes-Public Corporate Governance Bericht 2023 Download Bericht 2023 View Bundes-Public Corporate Governance Bericht 2022 Download Bericht 2022 View Bundes-Public Corporate Governance Bericht 2021 Download Bericht 2021 View Bundes-Public Corporate Governance Bericht 2019/2020 Download Bericht
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Financial Reports
View Financial Report 2023 Download Financial Report 2023 View Financial Report 2022 Download Financial Report 2022 View Financial Report 2021 Download Financial Report 2021 View Financial Report 2020 Download Financial Report 2020 View Financial Report 2019 Download Financial Report 2019 View Finan
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Biomedical Sequencing Facility (BSF)
A Sequencing Platform for Genomic Medicine Next-generation sequencing (NGS) technologies have revolutionized genomic research over the last decade. With today’s advanced NGS protocols and sequencing instruments, it has become economically feasible to simultaneously sequence billions of DNA or RNA fr
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Proxygen GmbH
Proxygen GmbH Proxygen GmbH is a startup company with the mission to develop therapies against cancer and other life-threatening diseases by reprogramming the cellular protein quality control system. Proxygen is focused on particular small molecules called “molecular glue degraders” which induce pro
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Solgate GmbH
Solgate GmbH Solgate GmbH is the first startup company born out of a cooperation between CeMM and IST Austria and its mission is to develop drugs against solute carrier (SLC) proteins, the largest family of transporters, focusing on the important roles of SLCs in neurological diseases, metabolic dis
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Spin-offs
CeMM is the founding partner of six spin-off companies At CeMM, we are constantly striving to create and maintain an entrepreneurship environment for our scientists so they can focus on achieving maximum scientific innovation to improve healthcare. We promote and support the generation of new busine
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MyeloPro
MyeloPro MyeloPro is a research stage biopharmaceutical company, aiming to develop innovative therapeutics for the treatment of blood diseases/myeloproliferative neoplasms (MPNs). MyeloPro’s research focuses on the development of antibodies that target the mutated form of the protein called calretic
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Myllia
Myllia Myllia combines CRISPR screening with single-cell sequencing, leveraging two transformative technologies to enable genetic screening for complex phenotypes. The approach has broad applications in identifying novel drug targets or elucidating unknown mechanisms of action in drugs. www.myllia.c
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Haplogen
Haplogen Haplogen is a biopharmaceutical company with the mission to improve human health by combating infectious disease. Employing a proprietary genetics technology to identify host factors, Haplogen is building a pipeline of therapeutic programs in the area of virus-caused diseases. www.haplogen.
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Detail
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Register
/about-cemm/events/register/
ÖAW
Excellence in Research Dialogue, and Knowledge Transfer The Austrian Academy of Sciences (ÖAW) is Austria’s leading non-university institution for fundamental research. Founded in 1847, it operates under a legal mandate to promote science at the highest level, foster interdisciplinary dialogue, and
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About CeMM
Shaping the Future of Personalized Medicine CeMM is an interdisciplinary research institute of the Austrian Academy of Sciences committed to advancing the understanding of human diseases through basic and biomedical research. Located in a tailor-made building in the midst of the campus of the Medica
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LIBRA Project
Advancing Gender Equality in Academia CeMM is Partner In the LIBRA Project At CeMM, we recognize a critical issue: while approximately half of PhD students in Europe are women, the number of women researchers significantly declines at the postdoctoral level and drops dramatically in leadership posit
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Molecular Discovery Platform
Discover bioactive molecules, metabolites, and novel synthetic compounds The different kinds of biomolecules in our bodies are at the nexus of human health and disease. Some of these molecules can act as biomarkers that report on our health status, others have therapeutic benefits to modulate diseas
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#positivarbeiten
Respect & Non-Judgement CeMM endorses #positivarbeiten CeMM has proudly signed the #postivarbeiten declaration, reaffirming our ongoing commitment to fostering an open, inclusive, and respectful workplace. We strive to provide all employees with an optimal work environment where they can grow profes
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Elvira Welzig
Dr. Elvira Welzig © Michael Sazel Managing Director of the Ludwig Boltzmann Gesellschaft, Vienna. "At the Ludwig Boltzmann Gesellschaft we are proud to share a common goal with CeMM: to drive research and innovation, breaking the mould. In the past we cooperated very successfully on the topic of rar
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Funding
Third Party Funds Over the last few years CeMM was increasingly successful in raising third-party funds and fellowships by going through competitive proposal processes. CeMM gratefully acknowledges the Austrian Academy of Sciences as well as national and international funding organisations for their
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Vienna Ball of Sciences 2020
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Visit of artist Adriana Czernin to CeMM's Brain Lounge 2021
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Kinderuni and Long Night of Research 2022
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Visit of OeAW President Heinz Faßmann
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CeMM 15th Anniversary Symposium
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Visit Minister Mückstein 2021
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CeMM 15th Anniversary Party
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CeMM Christmas Party 2022
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CeMM 12th S.M.A.R.T. Lecture with Barbara Seidlhofer
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Visit of artist Jun Yang to CeMM's Brain Lounge 2023
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RESOLUTE & REsolution Final Conference 2023
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CeMM Landsteiner Lecture 2022
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CeMM Christmas Party 2023
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Vienna City Marathon 2022
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CeMM Outing 2023
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CeMM 11th S.M.A.R.T. Lecture with Oskar Aszmann
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CeMM & CCRI Summer Party 2023
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CeMM Landsteiner Lecture 2023
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CeMM Scientific Recess 2023
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Research Report 2022 Launch
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CeMM Alumni Gathering 2023
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Wiener Töchtertag 2023
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CeMM Visit Helmholtz President Otmar Wiestler
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MedUni Vienna Cancer Research Run 2024
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Visit of Minister Martin Polaschek 2023
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GSF awarded Wilhelm Exner Medal 2024
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Visit of the Italian Ambassador 2023
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Vienna Ball of Sciences 2023
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Science Ball 2024
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Rainbow Alliance for Life Sciences and Medicine at Vienna Pride Parade 2024
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EU-LIFE Strategy Group with Helga Nowotny and Heinz Faßmann 2024
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EU-LIFE Utopia Conference on Artificial Intelligence 2024
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EU-LIFE Frinc Concert Arena Vienna 2024
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CeMM Alumni Gathering Vienna 2024
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EU-LIFE Community Meeting 2024
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Long Night of Research LNF24
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Tech Transfer
Start Me Up! Technology Transfer at CeMM CeMM is committed to identifying, supporting, and developing its research discoveries into impactful solutions for society. The technology transfer office is here to assist in all areas of valorization. Together with the CeMM inventors, the IP and Tech Transf
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Public Lecture Michael Bronstein, AITHYRA Sep 2024 (Special Guest: Star-Tenor Michael Schade)
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Austrian Cross of Honour for Science and Art, First Class, Giulio Superti-Furga
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CeMM 13th S.M.A.R.T. Lecture with Ivan Krastev
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Visit by Professor Oliver Rathkolb
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CeMM Landsteiner Lecture 2024
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Korean Delegation from UNIST
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CeMM SAB Meeting June 2024
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CeMM Outing 2024
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Ewald Nowotny
Professor Dr. Ewald Nowotny © Michael Sazel Governor Oesterreichische Nationalbank “Medical research has more and more socioeconomic importance for Austrian society. Increase in average life span brings a shift in the disease profile of the nation, with disorders such as dementia, diabetes and cance
/about-cemm/arts-and-society/supporters/research-report-2014/ewald-nowotny/
Sabine Herlitschka
Dipl. Ing. Dr. Sabine Herlitschka, MBA © Michael Sazel Chief Executive Officer and Chief Technology Officer, Infineon Technologies Austria AG “Scientific excellence is one of the basic ingredients for successful enterprises such as Infineon Technologies Austria. CeMM is the best example of an up and
/about-cemm/arts-and-society/supporters/research-report-2014/sabine-herlitschka/
Publications
/research/publications/
David Livingston
Prof. Dr. David Livingston © Michael Sazel Deputy Director, Dana-Farber/Harvard Cancer Center, Boston, USA Chair of CeMM's Scientific Advisory Board "As the chair of the scientific advisory board (SAB), it is a treat to observe the impressive development of CeMM during the past few years. Indeed, un
/about-cemm/arts-and-society/supporters/research-report-2013/david-livingston/
Susan le Jeune d'Allegeershecque
Susan le Jeune d'Allegeershecque © Michael Sazel Her Britannic Majesty's Ambassador to the Republic of Austria "Austria and Britain share a belief that science and innovation are at the heart of sustainable economic growth.The research undertaken at CeMM is world-leading and could well change all ou
/about-cemm/arts-and-society/supporters/research-report-2013/susan-le-jeune-dallegeershecque/
Werner Lanthaler
Dr. Werner Lanthaler, MBA, MPA © Michael Sazel Chief Executive Officer of Evotec AG “As a biotech entrepreneur and from the perspective of a truly global industry I keep a close look at the medically-oriented research in my home country. I have seen CeMM grow from a bold idea into a remarkable resea
/about-cemm/arts-and-society/supporters/research-report-2014/werner-lanthaler/
Nadia Rosenthal
Prof. Dr. Nadia Rosenthal © Michael Sazel Director, Australian Regenerative Medicine Institute, Melbourne, AU Member of CeMM's Scientific Advisory Board “I have had the great pleasure to be a Member of CeMM’s Scientific Advisory Board (SAB) since the inception of the Institute. Within this role I ha
/about-cemm/arts-and-society/supporters/research-report-2013/nadia-rosenthal/
Fabiola Gianotti
Fabiola Gianotti © Claudia Marcelloni Particle Physicist, CERN, Geneva "I spent a few (regrettably, too few ) hours at CeMM, the Centre for Molecular Medicine of the Austrian Academy of Sciences, on a rainy day in November 2013. I was literally dazzled by the highly creative and stimulating atmosphe
/about-cemm/arts-and-society/supporters/research-report-2013/fabiola-gianotti/
Anton Zeilinger
Prof. Dr. Anton Zeilinger © Michael Sazel President of the Austrian Academy of Sciences “As an interdisciplinary research institute of the Austrian Academy of Sciences studying the human system and its molecular inner workings, the mission of CeMM is to assist in preparing the predictive, preventive
/about-cemm/arts-and-society/supporters/research-report-2013/anton-zeilinger/
Stermann & Grissemann
Stermann & Grissemann © Michael Sazel Comedians, TV-Stars, Compéres "Willkommen Österreich" “It is an honor and pleasure to dedicate our bodies to science - even though its for the purpose of a picture for now. We fully trust in CeMM to handle our and any other bodies with care. To a better world!”
/about-cemm/arts-and-society/supporters/research-report-2013/stermann-grissemann/
Dorothee Golz
Visual Artist
Dorothee Golz © Iris Ranzinger Visual Artist Dorothee Golz (*1960, Muehlheim, Germany) studied art in Strasbourg and in parallel art history and anthropology at the ­University of ­Freiburg. She has lived and worked in Vienna ­since 1988. ­Following her participation in documenta X (1997) her works
/about-cemm/arts-and-society/supporters/research-report-2012/dorothee-golz/
Esther Stocker
Visual Artist
Esther Stocker © Iris Ranzinger Visual Artist Esther Stocker (*1974, Silandro, Italy) studied at the Academy of Fine Arts, Vienna (1994–1999), at the Accademia die Belle Arti di Bera, Milano (1996) and the Art Center College of Design, Pasadena, CA (USA, 1999). In 2001 she received a state scholarsh
/about-cemm/arts-and-society/supporters/research-report-2012/esther-stocker/
Martin Walde
Visual Artist
Martin Walde © Iris Ranzinger Visual Artist Martin Walde (*1957, Innsbruck, Tyrol) studied at the Academy of Fine Art, Vienna. Among other things, he was awarded the Otto Mauer Prize in 1991 and the City of Vienna’s Prize for Fine Art (Preis der Stadt Wien für Bildende Kunst) in 2012. Martin Walde i
/about-cemm/arts-and-society/supporters/research-report-2012/martin-walde/
Peter Kogler
Visual Artist
Peter Kogler © Iris Ranzinger Visual Artist Peter Kogler (*1959, Innsbruck, Tyrol) studied stage design at the Academy of Fine Arts, Vienna. His work juxtaposes the perfectionism of new technologies with physical and organic motifs. Kogler regularly participates in numerous exhibitions, including pa
/about-cemm/arts-and-society/supporters/research-report-2012/peter-kogler/
Brigitte Kowanz
Visual Artist
Brigitte Kowanz © Iris Ranzinger Visual Artist Brigitte Kowanz (*1957, Vienna) studied at the Academy of Applied Art, Vienna (1975–1980) and has worked as Professor for Transmedia Art at the University of Applied Arts, Vienna since 1997. In 2009 she was awarded the Austrian State Prize for Fine Arts
/about-cemm/arts-and-society/supporters/research-report-2012/brigitte-kowanz/
Thomas Feuerstein
Visual Artist
Thomas Feuerstein © Iris Ranzinger Visual Artist The work of Thomas Feuerstein (*1968, Innsbruck, Tyrol) encompasses installations, objects, drawings and paintings as well as sculptures, photographs and videos. Substantial aspects of his art are modes of connection and analogies between art and scie
/about-cemm/arts-and-society/supporters/research-report-2012/thomas-feuerstein/
Eva Schlegel
Visual Artist
Eva Schlegel © Iris Ranzinger Visual Artist Eva Schlegel (*1960, Hall, Tyrol) studied with Oswald Oberhuber at the University of Applied Arts, Vienna (1979–1985) and served as Professor for Photography at the Academy of Fine Arts, Vienna (1997–2006). After participating in the Venice Biennial in 199
/about-cemm/arts-and-society/supporters/research-report-2012/eva-schlegel/
Walking Chair
Designers
Walking Chair © Iris Ranzinger Designers After working as a mechanical engineer and teacher, Karl E. Pircher (*1963), a native of South Tyrol, studied with Ron Arad at the University of Applied Arts, Vienna and received several international design-awards. Fidel Peugeot (*1969), a Swiss national, ha
/about-cemm/arts-and-society/supporters/research-report-2012/walking-chair/
Niki Lauda
F1 Champion, Airline Founder
Niki Lauda © Hans Leitner F1 Champion, Airline Founder "Being competent, professional, and very concentrated on one’s goals, are key factors to success in sports, business and, I am sure, also in science. From what I know, CeMM is a formula one racing house in medical research that we are already pr
/about-cemm/arts-and-society/supporters/research-report-2011/niki-lauda/
Robert Palfrader
Comedian
Robert Palfrader © Benedikt Loebell Austrian comedian in his most famous social satire role as the (fictitious) Austrian Emperor Robert Heinrich I, Seyffenstein is his (equally fictitious) chamberlain “Chamberlain Seyffenstein! These CeMM people are doing important research for the country. We shoul
/about-cemm/arts-and-society/supporters/research-report-2008/robert-palfrader/
Carolina Inama
TV presenter
Carolina Inama © Benedikt Loebell Presenter of the Austrian television (ORF) science magazine “Newton” “Top medical research is part of the basis for a healthy society. Moreover, it is important to get young people excited about modern, intriguing research. And that’s the challenge of my job!”
/about-cemm/arts-and-society/supporters/research-report-2008/carolina-inama/
Future Leaders in Molecular Medicine Workshop 2019
/press/picture-galleries/2019/future-leaders-in-molecular-medicine-workshop-2019/
Emeritus-Symposium Prof Siegfried Meryn 2019
/press/picture-galleries/2019/emeritus-symposium-prof-siegfried-meryn-2019/
CeMM-LBI Career Center Career Workshop 2019
/press/picture-galleries/2019/cemm-lbi-career-center-career-workshop-2019/
Health.DigitalCity.Wien 2019
/press/picture-galleries/2019/healthdigitalcitywien-2019/
CeMM Christmas Party 2019
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Summer Academy of the German Academic Scholarship Foundation 2019
/press/picture-galleries/2019/summer-academy-of-the-german-academic-scholarship-foundation-2019/
MAK Art Society Visit CeMM Time Capsule June 2019
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CAT CeMM Amateur Theatre Moliere July 2019
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Falling Walls Lab Competition 2019
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Donation Benjamin Landesmann 2019
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CeMM Outing 2019
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Summer Party 2019
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Kinderuni 2019
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CeMM Landsteiner Lecture 2019 Luke O'Neill
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2nd RESOLUTE Consortium Meeting June 2019
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Alumni Kick-Off Event May 2019 (Part 1)
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Alumni Kick-Off Event May 2019 (Part 2)
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SAB Visit of Ephesos Museum 2019
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CeMM Scientific Recess 2019
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LIBRA Networking Event 2019
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SAB Dinner City Hall 2019
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Visit of Singapore's Minister for Foreign Affairs 2018
/press/picture-galleries/2018/visit-of-singapores-minister-for-foreign-affairs-2018/
Welcome Event CeMM and LBI-RUD Adjunct PIs 2018
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VBCeMM Kick-Off Event 2018
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S.M.A.R.T. Lecture December 2018 Wolfgang Lutz
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CeMM Scientific Recess 2019 (Social Activity)
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CeMMinar Vander Heiden 2018
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S.M.A.R.T. Lecture & Brain Lounge Discussion with Jan Gehl March 2018
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Blue Book Challenge 2017 | Category 11 In a holiday or relaxing setting
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Blue Book Challenge 2017 | Category 12: Anything else creative
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Blue Book Challenge 2017 | Category 10: Photobombing
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CeMM Landsteiner Lecture 2018 Yasmine Belkaid
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BEOPEN Science & Society Festival FWF 2018
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Vienna Ball of Sciences 2018
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Long Night of Research 2018
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Blue Book Challenge 2017 | Category 4: Doing/Watching Sports
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Blue Book Challenge 2017 | Category 2: In Front of a Landmark
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Blue Book Challenge 2017 | Category 8: With the "number 10"
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Blue Book Challenge 2017 | Category 3: In Everyday Life
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Blue Book Challenge 2017 | Category 9: Flashmobbing
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Blue Book Challenge 2017 | Category 6: Still Life
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Blue Book Challenge 2017 | Category 7: With a VIP
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Blue Book Challenge 2017 | Category 5: At An Event
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Artificial Hearts Josephinum Exhibition & Brain Lounge Discussion 2017
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Blue Book Challenge 2017 | Category 1: Most far away place
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Visit of President Van der Bellen & Mayor Häupl 2017
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CeMM 10 Years Celebration Part III
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CeMM 10 Years Celebration Part II
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SAB Meeting 09-12 April 2017
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CeMM 10 Years Celebration
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CeMM Outing 2017
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LIBRA Workshop 2017 “Best Practice in Gender-Inclusive Recruitment Processes”
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Italian Embassy, Order of Merit Giulio Superti-Furga 2017
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ERC President Jean-Pierre Bourguignon visit Vienna 2017
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S.M.A.R.T. Lecture November 2016 Mathieu Ossendrijver
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S.M.A.R.T. Lecture March 2017 Hermann Hauser
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CeMM Landsteiner Lecture 2017 with Jay Bradner
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Vienna Ball of Sciences 2017
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CeMMinars
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CeMM Landsteiner Lecture 2016 Emmanuelle Charpentier
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EU-LIFE Scientific Workshop 2016, CeMM Vienna
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EU-LIFE Strategy Meeting 2016, CeMM Vienna
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CeMM Outing 2016 Schönbrunn
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1st CeRUD Symposium 2016
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Long Night of Research 2016
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Summer Party 2016
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HaploDay 2016
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S.M.A.R.T. Lecture October 2015 Albert-László Barabasi
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Award Ceremony Ludwig Boltzmann Institute Kaan Boztug 2015
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Visit of President Mattarella & President Fischer September 2015
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CeMM at "Tag der offenen Tür des BMWFW" November 2016
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CeMM Outing 2015 Central Cemetery
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Special Seminar January 2016 Nieng Yan
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Refugees Awareness Expert Talk 2016
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Vienna Ball of Sciences 2016
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S.M.A.R.T. Lecture March 2015 Peter Brabeck-Letmathe
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CeMM Landsteiner Lecture 2015 Laurie H. Glimcher
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Sterntalerhof Charity Project June 2015
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Presentation Research Report 2015
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Opening CeMM Time Capsule 2015
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Research Report 2013
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Brain Lounge Gallery
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SAB Meeting 2015
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Opening Symposium CeRUD February 2014
28 February 2014
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S.M.A.R.T. Lecture March 2014 Gian Domenico Borasio
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Brain Lounge Opening Ceremony November 2012
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Landsteiner Lecture 2014 David M. Sabatini
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Novel strategy to anti-cancer therapy
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EMBanniversary 2014 Pictures
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Long Night of Research 2014
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AustroDrugs 2014
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Research Reports
View Research Report 2024 Download the RESEARCH REPORT 2024 View Research Report 2023 Download the RESEARCH REPORT 2023 View Research Report 2022 Download the RESEARCH REPORT 2022 Watch "The Famous Scientist Project" video View Research Report 2021 Download the RESEARCH REPORT 2021 Download the RESE
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S.M.A.R.T. Lecture November 2013 Fabiola Gianotti
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CeMM Landsteiner Lecture 2013 Hans Clevers
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CeMM Research Building
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Publications
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Detail
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Downloads
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X.com
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People at CeMM
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Metabolomics Facility
The Metabolomics Facility at CeMM aims to provide the highest quality metabolomics analyses on biological and biomedical research samples to its users. Services include method development for the detection and quantification of novel metabolites, systematic screening of established metabolite classe
/business-opportunities/research-facilities/molecular-discovery-platform/metabolomics-facility/
Proteomics Facility
The Proteomics Facility provides services using state-of-the-art, mass spectrometry-based proteomics applications to support scientific research groups engaged in both basic and translational research. The specialized design of the mass spectrometry (MS) laboratory ensures the highest performance st
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Research
Research Fields at CeMM Show all Groups Aging André Rendeiro CeMM Laura de Rooij CeMM Drug Discovery Giulio Superti-Furga CeMM Stefan Kubicek CeMM Georg Winter CeMM Genomic Medicine Joerg Menche Uni Vienna/Lerutz Labs Christoph Bock CeMM Medical Clinic Thomas Reiberger MedUni Vienna Georg Stary MedU
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PhD Call 2025
/phd-call-2025/
Christoph Bock Group
Research Focus The Bock Lab , based at CeMM and at the AI Institute of the Medical University of Vienna, investigates single cells in their spatial and temporal context – as building blocks of organ function, drivers of human disease, and programmable cell-based therapies. We pursue collaborative re
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Florian Grebien Group
Research Focus We study the molecular mechanisms underlying pediatric leukemia development and progression to identify novel vulnerabilities of childhood cancers. Using a wide array of cutting-edge technologies and state-of-the-art methods, we unveil how genetic mutations contribute to cancer develo
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Kaan Boztug Group
Research Focus Inherited defects of the immune system—referred to as primary immunodeficiencies (PIDs)—represent powerful, naturally occurring models to investigate key components of human immune function. Many PIDs present with features of autoimmunity or autoinflammation . Autoimmunity arises when
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Teams
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Giulio Superti-Furga Group
Research Focus Key for any living entity, such as a human cell, is the ability to contain an own environment within membranes that not only preserves the genetic material, but also allows chemical reactions to be efficient and generate energy. Management of the interface between the external world a
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Andreas Villunger Publications
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Andreas Villunger Funding
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Andreas Villunger People
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Georg Winter Fellowships
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Georg Winter Publications
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Georg Winter Funding
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Georg Winter People
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Andreas Villunger Group
Research Focus Andreas Villunger's research focuses on the role of pro-apoptotic BH3-only proteins in lymphocyte transformation and anti-cancer treatment responses, revealing for the first time that cell death induced by radiotherapy can have pro-tumorigenic effects. In recent years, his team has be
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Business Opportunities
Driving Innovation Through Research and Technology CeMM actively fosters innovation and entrepreneurship by promoting new business opportunities that emerge from its cutting-edge biomedical research and the creative ideas of its scientists and collaborators. As a leading biomedical research institut
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Laura de Rooij Group
Research Focus Endothelial cells line the interior surface of all blood vessels and are essential for the regulation of vascular tone, blood vessel growth, inflammation, permeability, and coagulation. Throughout the body’s organs and tissues, the endothelium shows a remarkable degree of structural,
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Join CeMM
Advance Your Career in Molecular Medicine © Klaus Pichler / CeMM At CeMM , we offer more than employment — we provide a platform for scientists, technicians, and professionals to pursue meaningful careers in a world-class biomedical research environment . Situated in the heart of Vienna’s renowned m
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Content Elements
Research Report 2024 The CeMM Research Report 2024 explores the central role of mathematics in life sciences. From atomic interactions to complex biological systems, the report highlights how equations underpin our understanding of measurable and predictable phenomena. As a creative expression of th
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Groups
Groups at CeMM CeMM is currently home to 8 Core Principal Investigators and 12 Adjunct Principal Investigators , all exploring fundamental questions in molecular medicine . CeMM’s scientific excellence is reflected in its outstanding record of competitive funding. The research teams include 11 recip
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The CeMM Experience
The CeMM Experience Excellent Research, Training, & Work-Life Balance © Franzi Kreis / CeMM At CeMM, life goes beyond the laboratory bench. We are committed to performing world-class scientific research while fostering a vibrant and supportive training environment for the next generation of scientif
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Laura de Rooij Fellowships
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PostDoc Representatives
PostDoc Representatives 2025 f.l.t.r. Gabriel Onea (Superti-Furga Lab), Michael Kraakman (Boztug Lab) Cheryl van de Wetering (Boztug Lab), Brianda Santini (Superti-Furga Lab) / © Franzi Kreis/CeMM The PostDoc Reps, PhD Reps, and Research Technician Reps, and PostDoc Reps are elected annually by thei
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Sponsor Us
Contribute to the Preventive, Predictive, Personalized Medicine of the Future Operations in CeMM’s research building, located in the middle of Vienna’s medical campus, began in 2011. 15 years later, new investments in instruments and facility infrastructure are urgently needed to ensure continued su
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Who We Are
A Center of Excellence for Molecular Medicine © Klaus Pichler / CeMM At CeMM , the Research Center for Molecular Medicine of the Austrian Academy of Sciences, we are dedicated to advancing the understanding of human biology and disease at the molecular level. Located in the heart of Vienna’s Medical
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Research Facilities
Technology and Expertise © Klaus Pichler / CeMM Two research facilities with cutting-edge technologies and expertise are dedicated to support scientists at CeMM, the Medical University of Vienna as well as other cooperation partners: The Biomedical Sequencing Facility (BSF) is Austria’s first techno
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EU-LIFE
A Strategic Alliance for Excellence in Life Sciences EU-LIFE is an alliance of leading European research institutes in the life sciences, united by a shared commitment to excellence, open science, and shaping the future of research in Europe. Founded in 2013, EU-LIFE brings together independent inst
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Scientific Advisory Board
Front row (left to right): Janet Kelso, Carl-Henrik Heldin, Emmanuelle Charpentier. Back row (left to right): Hidde Ploegh, Aaron Ciechanover, Derek Tan. CeMM’s international Scientific Advisory Board members visit the institute on a regular basis (every 18 months) to provide feedback on ongoing pro
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Genom Austria
A Scientific and Cultural Pioneering and Educational Project What is Genom Austria? The technical possibilities for examining our genetic constitution with genome sequencing are developing quickly. Today, genomes can be sequenced quickly and at a significantly lower cost than in the past. Next-gener
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PostDoc Program
CeMM Pre-ERC Postdoc Program in Celullar, Molecular, and Digital Medicine © Klaus Pichler / CeMM CeMM is renowned as a leading training institute with an outstanding track record of guiding postdoctoral researchers to become internationally recognized principal investigators and entrepreneurs. Launc
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Research Report Signup
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Application Process
Interested in joining a world-class PhD progra m in molecular medicine? Below you will find everything you need to know about eligibility requirements, the application process, and important dates and deadlines for the CeMM PhD Call. Eligibility Criteria To be eligible for the CeMM PhD Program , app
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Program Structure
Postdoctoral training at CeMM is designed to recognize the unique and diverse needs of researchers at this career stage. Rather than imposing rigid mandates, CeMM provides tailored opportunities that empower postdocs to define and pursue their own scientific ambitions. Selected candidates join CeMM
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Research Technicians
Research Technicians at CeMM Essential Support for Biomedical Research © Klaus Pichler / CeMM Research Technicians (RTs) are an integral part of CeMM’s laboratories and core facilities , contributing essential expertise that drives biomedical research forward. One of CeMM's key mission is to unlock
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Career Path
CeMM offers a clear and structured career path for Research Technicians , recognizing and supporting professional growth at every stage. At CeMM, technicians are essential to the success of scientific research, and their career development is taken seriously. The technician career path is divided in
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Research Technician Representatives
Research Technician Representatives 2025 f.l.t.r. Tatyana Tyschuk (Busslinger Lab), Julio García (Superti-Furga Lab), Anna Hurt (Boztug Lab), Hannah Riegler (NGS), Juan Sanchez (MDP), Dhanlakshmi Shunmugam (Admin/Scientific Support) / © Franzi Kreis/CeMM The Research Technician Reps, PhD Student Rep
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PhD Student Representatives
PhD Student Representatives 2025 f.l.t.r. Katharina Bonitz (Reiberger Lab), Jamie Reilly (Kubicek Lab), Lisa Kainacher (Winter Lab), Caroline Schaetz (Winter Lab), Katja Sommer (Reiberger Lab), Michael Schoeber (Superti-Furga Lab) / © Franzi Kreis/CeMM The PhD Student Reps, Research Technician Reps,
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Program Structure
The CeMM PhD Program offers an exceptional doctoral training experience that combines rigorous academic coursework , hands-on research , and personalized mentoring , and is based on the guidelines of the Medical University of Vienna (Doctoral Program UN94). Designed for aspiring scientists in molecu
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Alumni Board
Meet the CeMM Alumni Board Driving the Vision of our Alumni Network The CeMM Alumni Board serves as the official representative body of the CeMM Alumni Network , playing a central role in shaping its direction and initiatives. In close collaboration with CeMM’s Administrative Director, Anita Ender,
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Barlow Award
In Memory of Denise P. Barlow Honoring a Pioneer in Molecular Biology © Lisl Spurny-Schwarzmüller (watercolour portrait) / Klaus Pichler On 21 October 2023, we marked the sixth anniversary of the passing of Denise P. Barlow, a trailblazing molecular biologist who left a lasting impact on the scienti
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What We Do
The CeMM Mission © Klaus Pichler / CeMM The mission of CeMM is to achieve maximum scientific innovation in molecular medicine to improve healthcare. At CeMM, an international and creative team of scientists and medical doctors pursues free-minded basic life science research in a large and vibrant ho
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How We Work
Interdisciplinary. Collaborative. Impact-Driven. © Klaus Pichler / CeMM At CeMM , our approach to research is defined by scientific curiosity, technical excellence, and a deep commitment to improving human health. We believe that tackling complex biomedical questions requires collaboration across di
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Opportunities
Partner with CeMM Driving Innovation through Strategic Collaboration © Klaus Pichler / CeMM At CeMM, collaboration is at the core of our scientific mission. We believe that innovation in molecular medicine research is fueled by strong, interdisciplinary partnerships across academia, healthcare, and
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CeMM Alumni Gathering 2026
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Georg Winter Group
Research Focus Throughout his career, Georg Winter has been inspired by opportunities that emerge from looking at biology through the lens of small molecules. Small molecules not only represent a universal currency for biological communication, controlling processes from quorum sensing in bacteria t
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PhD Program
CeMM PhD Program in Molecular Technologies & Systems Medicine © Wolfgang Däuble / CeMM The CeMM PhD Program offers an exceptional opportunity for aspiring scientists to join a cutting-edge, international research environment at one of Europe’s leading centers for molecular medicine. Based in Vienna,
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Education & Training
Empowering the Next Generation of Scientists © Klaus Pichler / CeMM CeMM is committed to training the biomedical leaders of tomorrow . Our structured educational programs, hands-on research environment, and global collaborations make CeMM a top choice for Principal Investigators, PhD students, PostD
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Application Process
Advance your path to research independence with the CeMM Pre-ERC Postdoc Program . Below you will find key information on eligibility, how to apply, and the application timeline for the program. Eligibility Criteria To apply for the CeMM Pre-ERC Postdoc Program, you must meet the following requireme
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Our Accountability
Science With Responsibility At CeMM, we are committed to the highest standards of scientific integrity, transparency, and social responsibility. As a publicly funded research institute of the Austrian Academy of Sciences, we understand our accountability to the scientific community, our partners, an
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Facts & Figures 2024
Listed by number of persons per field of work. In the observation period, CeMM employed an average of 145.4 full-time equivalents (FTE). This does not include CeMM members who have their primary affiliation with one of the Adjunct Principal Investigator groups. In total, 299 people were associated w
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Vienna Science Ball 2025
© GSF, AE, Kerstin Zimmermann, Ludwig Schedl / CeMM
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CeMM Faculty Retreat 2025
© Hans Leitner / CeMM
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18th Landsteiner Lecture with Tony Wyss-Coray
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Töchter Tag at CeMM 2025
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Landsteiner Lectures
Named in honor of Karl Landsteiner, the Viennese discoverer of blood groups, the CeMM Landsteiner Lecture is given annually since 2007. The speakers, carefully selected by the faculty at CeMM, are prominent scientists whose molecular research are deemed to have had a significant impact on medicine.
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Chairs to Share
In 2020, CeMM's entrance area was enriched by an art installation by Dorothee Golz. With CHAIRS to SHARE, objects conceived in an art context leave the museum space to become both useful furniture and a powerful metaphor at the entrance to CeMM. One can get involved with CHAIRS to SHARE as a viewer
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Wall Sculpture
In 2018, the western wall of the 8th floor seminar room has become home to a sculpture of lacquered wood and metal by Klaus Pamminger, who had already contributed to the CeMM Brain Lounge. Called “Stiegenhaus, 11 Square Albin Cachot, 75013 Paris-13E RC01-BDJ”, it is inspired by the staircase and lan
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14th CeMM S.M.A.R.T. Lecture with Walter Pohl
© Bubu Dujmic / CeMM
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CeMM & CCRI at Vienna City Marathon 2025
© Franzi Kreis / CeMM
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CeMM Ice Hockey Game
© Bubu Dujmic / CeMM
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Home
CeMM Research Center for Molecular Medicine Science is our Medicine More about CeMM Research Report 2024 19 May 2025 Deciphering Cellular Logistics: A First Blueprint of Chemical Transport Pathways An unprecedented international effort to decode how cells manage the transport of chemical substances
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Recruitment Process
A Fair & Transparent Hiring Process at CeMM © Iris Ranzinger / CeMM At CeMM, we truly value our employees. To attract the best talent with the right mix of skills, experience, personality, and potential, we invest significant time and effort into our recruitment process . Our selection process is co
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Art Façade
© Iris Ranzinger / CeMM The CeMM building was designed by architect Ernst Kopper who created a structure full of light with much open space for the needs and comfort of modern molecular biology laboratories as well as room to house sophisticated high-tech scientific equipment. The eastern side of th
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Brain Lounge
Spin around, think around, reload your brain… The CeMM Brain Lounge is more than a room: It is an art installation and open-end experiment dedicated to the power of thinking. The CeMM Brain Lounge was created by Walking Chair (Karl Emilio Pircher and Fidel Peugeot) in close cooperation with the CeMM
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CeMM Kapsel / Time Capsule
On 3 June 2015, the CeMM Kapsel / Time Capsule a Science and Art project by Martin Walde and Giulio Superti-Furga was officially opened by Andreas Mailath-Pokorny, Vienna City Councillor for Cultural Affairs and Science. The concept of the Time Capsule is based on Martin Walde's interaction with CeM
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HR Excellence at CeMM
Best Practices in Recruitment, Training & Career Progression © Klaus Pichler / CeMM CeMM has officially endorsed the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers for the Recruitment of Researchers as of 6 September 2022. This important step aligns CeMM
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Virtual Reality
VRNetzer A Virtual Reality Network Analysis Platform Networks offer a powerful way to visualize and analyze complex systems. However, depending on the size and complexity of the network, many visualizations are limited. Protein interactions in the human body constitute such a complex system that can
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Why CeMM?
Work at CeMM Advance Your Career with Us © Klaus Pichler / CeMM Are you ready to push the boundaries of science and innovation? CeMM, the international, independent, and interdisciplinary Research Center for Molecular Medicine of the Austrian Academy of Sciences, offers you a unique opportunity to t
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Ticks' tricks: immunomodulatory effects of ixodid tick saliva at the cutaneous tick-host interface
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2024
Thoughts for the future
Lona M Alkhalaf, Cheryl Arrowsmith, Emily P Balskus, Giovanna Bergamini, Rashna Bhandari, Christopher J Chang, Peng Chen, Xing Chen, Alessio Ciulli, Julia A Cricco, Benjamin G Davis, Martina Delbianco, Natalia Dudareva, Erin Dueber, Fleur Ferguson, Priscila Oliveira de Giuseppe, Itaru Hamachi, Ming Chen Hammond, Stavroula K Hatzios, Won Do Heo, Jon Paul Janet, Siddhesh S Kamat, Stefan Knapp, Yamuna Krishnan, Kathrin Lang, Luca Laraia, Reuben B Leveson-Gower, Xiang David Li, David R Liu, Mo-Fang Liu, Nir London, Nilkamal Mahanta, Cristina Mayor-Ruiz, Tom Muir, Mário Tyago Murakami, Hyun-Woo Rhee, Matt Robers, Alex Satz, Brenda A Schulman, Ben Shen, Brian Shoichet, Erick Strauss, Tsutomu Suzuki, Pratyush Tiwary, Herbert Waldmann, Thomas R Ward, Amy Weeks, Eranthie Weerapana, Georg Winter
Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2.
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2024
Ex vivo imaging-based high content phenotyping of patients with rheumatoid arthritis
Felix Kartnig, Michael Bonelli, Ulrich Goldmann, Noemi Mészáros, Nikolaus Krall, Daniel Aletaha, Leonhard X Heinz, Giulio Superti-Furga
EBioMedicine. 2025 Jan;111:105522. doi: 10.1016/j.ebiom.2024.105522. Epub 2024 Dec 26.
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2025
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Gernot Wolf, Conner Craigon, Shao Thing Teoh, Patrick Essletzbichler, Svenja Onstein, Diane Cassidy, Esther C H Uijttewaal, Vojtech Dvorak, Yuting Cao, Ariel Bensimon, Ulrich Elling, Alessio Ciulli, Giulio Superti-Furga
Cell Chem Biol. 2025 Feb 20;32(2):291-306.e6. doi: 10.1016/j.chembiol.2024.11.009. Epub 2025 Jan 3.
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2025
Marsilea: an intuitive generalized paradigm for composable visualizations
Yimin Zheng, Zhihang Zheng, André F Rendeiro, Edwin Cheung
Genome Biol. 2025 Jan 6;26(1):5. doi: 10.1186/s13059-024-03469-3.
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2025
Mitotic lethality prevents inflammation
Christian Zierhut, Andreas Villunger
Nat Cell Biol. 2025 Jan;27(1):7-8. doi: 10.1038/s41556-024-01529-1.
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2025
Restimulation by macrophages exhausts T cells
Fernando Fernández-García, Barbara B Maier
Immunity. 2025 Jan 14;58(1):12-14. doi: 10.1016/j.immuni.2024.12.010.
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2025
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Huanyu Z Li, Ashley C W Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M Kessler, Nicola A Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B Sauer
Nat Commun. 2025 Jan 16;16(1):721. doi: 10.1038/s41467-025-55942-7.
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2025
Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell
Wen-An Wang, Andrea Garofoli, Evandro Ferrada, Christoph Klimek, Barbara Steurer, Alvaro Ingles-Prieto, Tanja Osthushenrich, Aidan MacNamara, Anders Malarstig, Tabea Wiedmer, Giulio Superti-Furga
Life Sci Alliance. 2025 Jan 30;8(4):e202403028. doi: 10.26508/lsa.202403028. Print 2025 Apr.
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2025
Single-cell CRISPR screening in mouse brain
Eugenia V Pankevich, Christoph Bock
Nat Protoc. 2025 Feb 12. doi: 10.1038/s41596-024-01128-2. Online ahead of print.
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2025
Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia
Zainab M Golwala, Helena Spiridou Goncalves, Ranjita Devi Moirangthem, Grace Evans, Sabrina Lizot, Coco de Koning, Alexandrine Garrigue, Marta Martin Corredera, Juan Moises Ocampo-Godinez, Evey Howley, Susanne Kricke, Arnold Awuah, Irene Obiri-Yeboa, Rajeev Rai, Neil Sebire, Fanette Bernard, Victoria Bordon Cueto De Braem, Kaan Boztug, Theresa Cole, Andrew R Gennery, Scott Hackett, Sophie Hambleton, Mette Holm, Maaike A Kusters, Adam Klocperk, Antonio Marzollo, Nufar Marcus, Zohreh Nademi, Jana Pachlopnik Schmid, Herbert Pichler, Anna Sellmer, Pere Soler-Palacin, Maarja Soomann, Paul Torpiano, Joris van Montfrans, Stefan Nierkens, Stuart Adams, Matthew Buckland, Kimberly Gilmour, Austen Worth, Adrian J Thrasher, E Graham Davies, Isabelle André, Alexandra Y Kreins
Clin Immunol. 2025 May;274:110453. doi: 10.1016/j.clim.2025.110453. Epub 2025 Feb 16.
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2025
Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring
Takaya Saito, Marit Espe, Maren Mommens, Christoph Bock, Jorge M O Fernandes, Kaja Helvik Skjærven
PLoS One. 2025 Feb 24;20(2):e0317770. doi: 10.1371/journal.pone.0317770. eCollection 2025.
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2025
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation
Teresa Neuwirth, Daniel Malzl, Katja Knapp, Panagiota Tsokkou, Lisa Kleissl, Anna Gabriel, Baerbel Reininger, Christian Freystätter, Nara Marella, Ana P Kutschat, Elisabeth Ponweiser, Arvand Haschemi, Davide Seruggia, Jörg Menche, Erwin F Wagner, Georg Stary
Immunity. 2025 Mar 11;58(3):632-647.e12. doi: 10.1016/j.immuni.2025.02.011. Epub 2025 Feb 28.
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2025
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions
Anzhelika Karjalainen, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, David Martin, Felix Sternberg, Milica Krunic, Marlies Dolezal, Nikolaus Fortelny, Matthias Farlik, Sabine Macho-Maschler, Caroline Lassnig, Katrin Meissl, Lena Amenitsch, Therese Lederer, Elena Pohl, Dagmar Gotthardt, Christoph Bock, Thomas Decker, Birgit Strobl, Mathias Müller
Cell Mol Life Sci. 2025 Mar 2;82(1):98. doi: 10.1007/s00018-025-05625-9.
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2025
Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression
Junbum Kim, Hiranmayi Ravichandran, Liron Yoffe, Bhavneet Bhinder, Kyle Finos, Arshdeep Singh, Bradley B Pua, Stewart Bates, Bevan Emma Huang, Andre F Rendeiro, Vivek Mittal, Nasser K Altorki, Timothy E McGraw, Olivier Elemento
bioRxiv [Preprint]. 2025 Feb 22:2025.02.19.637138. doi: 10.1101/2025.02.19.637138.
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2025
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation
Ci Zhu, Nicole Boucheron, Osamah Al-Rubaye, Brian K Chung, Liv Wenche Thorbjørnsen, Thomas Köcher, Michael Schuster, Thierry Claudel, Emina Halilbasic, Victoria Kunczer, Fanziska Muscate, Lois L Cavanagh, Darina Waltenberger, Alexander Lercher, Anna Ohradanova-Repic, Philipp Schatzlmaier, Tatjana Stojakovic, Hubert Scharnagl, Andreas Bergthaler, Hannes Stockinger, Samuel Huber, Christoph Bock, Lukas Kenner, Tom H Karlsen, Wilfried Ellmeier, Michael Trauner
Gut. 2025 Mar 7:gutjnl-2024-333297. doi: 10.1136/gutjnl-2024-333297. Online ahead of print.
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2025
Evaluation of Patients with Combined Immunodeficiency: A Single Center Experience
Hatice Firatoglu, Caner Aytekin, Figen Dogu, Sevgi Kostel Bal, Sule Haskologlu, Kaan Boztug, Aydan Ikinciogullari
Iran J Immunol. 2025 Mar 30;22(1):89-99. doi: 10.22034/iji.2025.103499.2844.
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2025
Fluorescent PyrAte-(S)-citalopram conjugates enable imaging of the serotonin transporter in living tissue
Oliver J V Belleza, Iakovos Saridakis, Nadja K Singer, Xavier Westergaard, Sergio Armentia Matheu, Miran Lemmerer, Margaux Riomet, Pedro A Sánchez-Murcia, Nina Kastner, Stefanie Rukavina, Yi Xiao, Kathrin Jäntsch, Marco Niello, Klaus Schicker, David Sulzer, Leticia González, Nuno Maulide, Harald H Sitte
Chem Sci. 2025 Mar 3;16(14):6003-6013. doi: 10.1039/d4sc06949h. eCollection 2025 Apr 2.
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2025
Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma
Matarr Khan, Marlis Alteneder, Wolfgang Reiter, Thomas Krausgruber, Lina Dobnikar, Moritz Madern, Monika Waldherr, Christoph Bock, Markus Hartl, Wilfried Ellmeier, Johan Henriksson, Nicole Boucheron
Nat Commun. 2025 Mar 15;16(1):2565. doi: 10.1038/s41467-025-57590-3.
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2025
Lophine analogues as fluorophores for selective bioimaging of the endoplasmic reticulum
Danica Drpic, Fabián A Amaya-García, Miriam M Unterlass
Chem Commun (Camb). 2025 Apr 1;61(28):5293-5296. doi: 10.1039/d4cc06552b.
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2024
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Nianzhe He, Laura Depta, Cecilia Rossetti, Lucie Caramelle, Marko Cigler, Hogan P Bryce-Rogers, Marine Michon, Oliver Rafn Dan, Joseph Hoock, Julien Barbier, Daniel Gillet, Alison Forrester, Georg E Winter, Luca Laraia
Nat Chem Biol. 2025 Feb;21(2):203-214. doi: 10.1038/s41589-024-01653-x. Epub 2024 Jun 21.
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2024
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Marko Cigler, Hana Imrichova, Fabian Frommelt, Lucie Caramelle, Laura Depta, Andrea Rukavina, Chrysanthi Kagiou, J Thomas Hannich, Cristina Mayor-Ruiz, Giulio Superti-Furga, Sonja Sievers, Alison Forrester, Luca Laraia, Herbert Waldmann, Georg E Winter
Nat Chem Biol. 2025 Feb;21(2):193-202. doi: 10.1038/s41589-024-01614-4. Epub 2024 Jun 21.
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2024
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain
Philipp Starkl, Gustav Jonsson, Tyler Artner, Bruna Lenfers Turnes, Laura-Marie Gail, Tiago Oliveira, Aakanksha Jain, Nadine Serhan, Karel Stejskal, Karin Lakovits, Anastasiya Hladik, Meilin An, Keith M Channon, Hail Kim, Thomas Köcher, Wolfgang Weninger, Georg Stary, Sylvia Knapp, Victoria Klang, Nicolas Gaudenzio, Clifford J Woolf, Shweta Tikoo, Rohit Jain, Josef M Penninger, Shane J F Cronin
Sci Immunol. 2024 Aug 23;9(98):eadh0545. doi: 10.1126/sciimmunol.adh0545. Epub 2024 Aug 23.
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2024
Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist
Philipp Leippe, Prashant Donthamsetti, Tongil Ko, Cherise Stanley, Ehud Isacoff, Dirk Trauner
Angew Chem Int Ed Engl. 2024 Dec 2;63(49):e202411181. doi: 10.1002/anie.202411181. Epub 2024 Oct 29.
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2024
Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS Complex
Sophie Piech, Sven Brüschweiler, Josepha Westphalen, Katharina M Siess, Julio García Murias, Robert Konrat, Johannes W Bigenzahn, Giulio Superti-Furga
ACS Chem Biol. 2024 Sep 20;19(9):1942-1952. doi: 10.1021/acschembio.4c00077. Epub 2024 Aug 28.
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2024
Inherited human RelB deficiency impairs innate and adaptive immunity to infection
Tom Le Voyer, Majistor Raj Luxman Maglorius Renkilaraj, Kunihiko Moriya, Malena Pérez Lorenzo, Tina Nguyen, Liwei Gao, Tamar Rubin, Axel Cederholm, Masato Ogishi, Carlos A Arango-Franco, Vivien Béziat, Romain Lévy, Mélanie Migaud, Franck Rapaport, Yuval Itan, Elissa K Deenick, Irene Cortese, Andrea Lisco, Kaan Boztug, Laurent Abel, Stéphanie Boisson-Dupuis, Bertrand Boisson, Patrick Frosk, Cindy S Ma, Nils Landegren, Fatih Celmeli, Jean-Laurent Casanova, Stuart G Tangye, Anne Puel
Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2321794121. doi: 10.1073/pnas.2321794121. Epub 2024 Sep 4.
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2024
Hydrothermal synthesis of metal nanoparticles@hydrogels and statistical evaluation of reaction conditions' effects on nanoparticle morphologies
Olivier Gazil, D Alonso Cerrón-Infantes, Nick Virgilio, Miriam M Unterlass
Nanoscale. 2024 Oct 3;16(38):17778-17792. doi: 10.1039/d4nr00581c.
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2024
Diastereoselective hydride transfer enables a synthesis of chiral 1,5-carboxamido-trifluoromethylcarbinols
Roberto Tinelli, Manuel Schupp, Immo Klose, Saad Shaaban, Boris Maryasin, Leticia González, Nuno Maulide
Chem Sci. 2024 Sep 9;15(38):15751-6. doi: 10.1039/d4sc05049e. Online ahead of print.
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2024
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs
Georg E Winter
ACS Chem Biol. 2024 Oct 18;19(10):2089-2102. doi: 10.1021/acschembio.4c00191. Epub 2024 Sep 12.
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2024
Amplified centrosomes-more than just a threat
Eva Kiermaier, Isabel Stötzel, Marina A Schapfl, Andreas Villunger
EMBO Rep. 2024 Oct;25(10):4153-4167. doi: 10.1038/s44319-024-00260-0. Epub 2024 Sep 16.
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2024
Insights into the multifaceted role of interleukin-37 on human immune cell regulation
Lisa U Teufel, Vasiliki Matzaraki, Lukas Folkman, Rob Ter Horst, Simone J C F M Moorlag, Catharina M Mulders-Manders, Mihai G Netea, Thomas Krausgruber, Leo A B Joosten, Rob J W Arts
Clin Immunol. 2024 Nov;268:110368. doi: 10.1016/j.clim.2024.110368. Epub 2024 Sep 20.
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2024
High-temperature water unlocks urea as nitrogen-source towards imidazoles
Fabián Amaya-García, Lena Schittenhelm, Miriam M Unterlass
Green Chem. 2024 Sep 20;26(20):10411-10421. doi: 10.1039/d4gc01705f. eCollection 2024 Oct 14.
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2024
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing
Basheer Becerra, Sandra Wittibschlager, Zain M Patel, Ana P Kutschat, Justin Delano, Eric Che, Anzhelika Karjalainen, Ting Wu, Marlena Starrs, Martin Jankowiak, Daniel E Bauer, Davide Seruggia, Luca Pinello
bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612085. doi: 10.1101/2024.09.09.612085.
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2024
Probing the Chemical Space of Guanidino-Carboxylic Acids to Identify the First Blockers of the Creatine-Transporter-1
Clemens V Farr, Yi Xiao, Ali El-Kasaby, Manuel Schupp, Matej Hotka, Giovanni di Mauro, Amy Clarke, Miryam Pastor Fernandez, Walter Sandtner, Thomas Stockner, Christoph Klade, Nuno Maulide, Michael Freissmuth
Mol Pharmacol. 2024 Nov 18;106(6):319-333. doi: 10.1124/molpharm.124.000995.
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2024
NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities
Milad Rasouli, Selina Troester, Florian Grebien, Bianca F Goemans, C Michel Zwaan, Olaf Heidenreich
Hemasphere. 2024 Sep 25;8(9):e70013. doi: 10.1002/hem3.70013. eCollection 2024 Sep.
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2024
Aetiology-specific inflammation patterns in patients and rat models of compensated cirrhosis
Benedikt Silvester Hofer, Benedikt Simbrunner, Philipp Königshofer, Ksenia Brusilovskaya, Oleksandr Petrenko, Vlad Taru, Thomas Sorz, Kerstin Zinober, Georg Semmler, Stefan G Kauschke, Larissa Pfisterer, Michael Trauner, Mattias Mandorfer, Philipp Schwabl, Thomas Reiberger
Dig Liver Dis. 2025 Feb;57(2):450-458. doi: 10.1016/j.dld.2024.09.006. Epub 2024 Sep 28.
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2024
Bile acid metabolism and signalling in liver disease
Claudia D Fuchs, Benedikt Simbrunner, Maximillian Baumgartner, Clarissa Campbell, Thomas Reiberger, Michael Trauner
J Hepatol. 2025 Jan;82(1):134-153. doi: 10.1016/j.jhep.2024.09.032. Epub 2024 Sep 28.
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2024
Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3
Maja Zupančič, Erik Keimpema, Evgenii O Tretiakov, Stephanie J Eder, Itamar Lev, Lukas Englmaier, Pradeep Bhandari, Simone A Fietz, Wolfgang Härtig, Estelle Renaux, Andreas Villunger, Tomas Hökfelt, Manuel Zimmer, Frédéric Clotman, Tibor Harkany
Nat Commun. 2024 Oct 5;15(1):8631. doi: 10.1038/s41467-024-52762-z.
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2024
Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth
Apeksha Shapeti, Jorge Barrasa-Fano, Abdel Rahman Abdel Fattah, Janne de Jong, José Antonio Sanz-Herrera, Mylène Pezet, Said Assou, Emilie de Vet, Seyed Ali Elahi, Adrian Ranga, Eva Faurobert, Hans Van Oosterwyck
Nat Commun. 2024 Oct 6;15(1):8660. doi: 10.1038/s41467-024-52866-6.
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2024
Cyclin C promotes development and progression of B-cell acute lymphoblastic leukemia by counteracting p53-mediated stress responses
Jana Trifinopoulos, Julia List, Thorsten Klampfl, Klara Klein, Michaela Prchal-Murphy, Agnieszka Witalisz-Siepracka, Florian Bellutti, Luca L Fava, Gerwin Heller, Sarah Stummer, Patricia Testori, Monique L Den Boer, Judith M Boer, Sonja Marinovic, Gregor Hoermann, Wencke Walter, Andreas Villunger, Piotr Sicinski, Veronika Sexl, Dagmar Gotthardt
Haematologica. 2025 Apr 1;110(4):877-892. doi: 10.3324/haematol.2024.285701. Epub 2024 Oct 10.
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2024
Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity
Marina A Schapfl, Gina M LoMastro, Vincent Z Braun, Maretoshi Hirai, Michelle S Levine, Eva Kiermaier, Verena Labi, Andrew J Holland, Andreas Villunger
Nat Commun. 2024 Oct 15;15(1):8890. doi: 10.1038/s41467-024-53222-4.
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2024
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6
Thibault Viennet, Maolu Yin, Abhilash Jayaraj, Woojin Kim, Zhen-Yu J Sun, Yuko Fujiwara, Kevin Zhang, Davide Seruggia, Hyuk-Soo Seo, Sirano Dhe-Paganon, Stuart H Orkin, Haribabu Arthanari
Structure. 2024 Dec 5;32(12):2276-2286.e4. doi: 10.1016/j.str.2024.09.022. Epub 2024 Oct 17.
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2024
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis
Laura Gebetsberger, Zahra Malekshahi, Aron Teutsch, Gabor Tajti, Frédéric Fontaine, Nara Marella, André Mueller, Lena Prantl, Hannes Stockinger, Heribert Stoiber, Anna Ohradanova-Repic
Emerg Microbes Infect. 2024 Dec;13(1):2417868. doi: 10.1080/22221751.2024.2417868. Epub 2024 Oct 28.
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2024
Reply to: "Pyroptosis in liver failure: A twisted firestarter"
Vlad Taru, Thomas Reiberger
J Hepatol. 2025 Feb;82(2):e93-e94. doi: 10.1016/j.jhep.2024.10.021. Epub 2024 Oct 21.
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2024
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Valentina Stolz, Rafael de Freitas E Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier
Elife. 2024 Oct 28;13:e78738. doi: 10.7554/eLife.78738.
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2024
The adsorption of drugs on nanoplastics has severe biological impact
Leonard Dick, Patrick R Batista, Paul Zaby, Gabriele Manhart, Verena Kopatz, Lukas Kogler, Verena Pichler, Florian Grebien, Vince Bakos, Benedek G Plósz, Nikola Zlatkov Kolev, Lukas Kenner, Barbara Kirchner, Oldamur Hollóczki
Sci Rep. 2024 Oct 28;14(1):25853. doi: 10.1038/s41598-024-75785-4.
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2024
Caspase-2 kills cells with extra centrosomes
Dario Rizzotto, Vincenza Vigorito, Patricia Rieder, Filip Gallob, Gian Mario Moretta, Claudia Soratroi, Joel S Riley, Florian Bellutti, Stefano Li Veli, Alessia Mattivi, Michael Lohmüller, Sebastian Herzog, Beat C Bornhauser, Etienne D Jacotot, Andreas Villunger, Luca L Fava
Sci Adv. 2024 Nov;10(44):eado6607. doi: 10.1126/sciadv.ado6607. Epub 2024 Oct 30.
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2024
Optimising Transformation Efficiency in Borrelia: Unravelling the Role of the Restriction-Modification System of Borrelia afzelii and Borrelia garinii
Margarida Ruivo, Noémi Zsuzsa Kovács, Anna-Margarita Schötta, Theresa Stelzer, Laura Hermann, Verena Mündler, Andreas Bergthaler, Michael Reiter, Michiel Wijnveld
Int J Mol Sci. 2024 Oct 22;25(21):11343. doi: 10.3390/ijms252111343.
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2024
Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation
Vlad Taru, Gyongyi Szabo, Wajahat Mehal, Thomas Reiberger
J Hepatol. 2024 Nov;81(5):895-910. doi: 10.1016/j.jhep.2024.06.016. Epub 2024 Jun 20.
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2024
GPT-4 as a biomedical simulator
Moritz Schaefer, Stephan Reichl, Rob Ter Horst, Adele M Nicolas, Thomas Krausgruber, Francesco Piras, Peter Stepper, Christoph Bock, Matthias Samwald
Comput Biol Med. 2024 Aug;178:108796. doi: 10.1016/j.compbiomed.2024.108796. Epub 2024 Jun 22.
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2024
Correction: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity
Marcello Polesel, Alvaro Ingles-Prieto, Eirini Christodoulaki, Evandro Ferrada, Cédric Doucerain, Patrick Altermatt, Michelle Knecht, Michael Kuhn, Anna-Lena Steck, Maria Wilhelm, Vania Manolova
Biometals. 2024 Aug;37(4):1037-1038. doi: 10.1007/s10534-024-00615-z.
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2024
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
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Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3.
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2024
Combination of compound screening with an animal model identifies pentamidine to prevent Chlamydia trachomatis infection
Katja Knapp, Romana Klasinc, Anna Koren, Magdalena Siller, Ruth Dingelmaier-Hovorka, Mathias Drach, Juan Sanchez, David Chromy, Marlene Kranawetter, Christoph Grimm, Andreas Bergthaler, Stefan Kubicek, Hannes Stockinger, Georg Stary
Cell Rep Med. 2024 Jul 16;5(7):101643. doi: 10.1016/j.xcrm.2024.101643. Epub 2024 Jul 8.
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2024
Differential regulation of mitochondrial uncoupling protein 2 in cancer cells
Taraneh Beikbaghban, Ludovica Proietti, Jessica Ebner, Roko Sango, Thomas Rattei, Thomas Weichhart, Florian Grebien, Felix Sternberg, Elena E Pohl
Biochim Biophys Acta Bioenerg. 2024 Nov 1;1865(4):149486. doi: 10.1016/j.bbabio.2024.149486. Epub 2024 Jul 8.
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2024
Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes, Belén Lucas, Natalie S Scholes, Xiu-Fen Cheng, Daniel C Scott, Matthias Bischoff, Katharina Reich, Raphael Gasper, María Lucas, Teng Teng Xu, Lisa-Marie Pulvermacher, Lara Dötsch, Hana Imrichova, Alexandra Brause, Kesava Reddy Naredla, Sonja Sievers, Kamal Kumar, Petra Janning, Malte Gersch, Peter J Murray, Brenda A Schulman, Georg E Winter, Slava Ziegler, Herbert Waldmann
bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857. doi: 10.1101/2024.07.10.602857.
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2024
Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer
Carolina Mangana, Barbara B Maier
Cancer Cell. 2024 Aug 12;42(8):1329-1331. doi: 10.1016/j.ccell.2024.06.016. Epub 2024 Jul 18.
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2024
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A M Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F Ooms, Jeppe Tranberg-Jensen, Jesper S Hansen, Josefina Stanka, Hubert J Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P IJzerman, David B Sauer, Laura H Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F Ecker, Kilian V M Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
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2024
Domino Conjugate Addition-1,4-Aryl Migration for the Synthesis of α,β-Difunctionalized Amides
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JACS Au. 2024 Jun 17;4(7):2456-2461. doi: 10.1021/jacsau.4c00378. eCollection 2024 Jul 22.
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2024
High histamine levels are associated with acute-on-chronic liver failure and liver-related death in patients with advanced chronic liver disease
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Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer
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Nat Commun. 2024 Aug 13;15(1):6949. doi: 10.1038/s41467-024-51025-1.
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Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma
Mariem Radhouani, Philipp Starkl
Front Allergy. 2024 Aug 2;5:1423938. doi: 10.3389/falgy.2024.1423938. eCollection 2024.
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Degradome analysis to identify direct protein substrates of small-molecule degraders
Marco Jochem, Anna Schrempf, Lina-Marie Wagner, Dmitri Segal, Jose Cisneros, Amanda Ng, Georg E Winter, Jeroen Krijgsveld
Cell Chem Biol. 2025 Jan 16;32(1):192-200.e6. doi: 10.1016/j.chembiol.2024.10.007. Epub 2024 Nov 12.
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Protein Binder Toolbox for Studies of Solute Carrier Transporters
Zuzana Gelová, Alvaro Ingles-Prieto, Tina Bohstedt, Fabian Frommelt, Gamma Chi, Yung-Ning Chang, Julio Garcia, Gernot Wolf, Lucia Azzollini, Sara Tremolada, Andreea Scacioc, Jesper S Hansen, Iciar Serrano, Aida Droce, Jenifer Cuesta Bernal, Nicola A Burgess-Brown, Elisabeth P Carpenter, Katharina L Dürr, Peter Kristensen, Eric R Geertsma, Saša Štefanić, Lia Scarabottolo, Tabea Wiedmer, Vera Puetter, David B Sauer, Giulio Superti-Furga
J Mol Biol. 2024 Aug 15;436(16):168665. doi: 10.1016/j.jmb.2024.168665. Epub 2024 Jun 13.
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Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies
Bernhard Jandl, Satish Dighe, Maximillian Baumgartner, Athanasios Makristathis, Christoph Gasche, Markus Muttenthaler
Gastroenterology. 2024 Nov;167(6):1098-1112.e5. doi: 10.1053/j.gastro.2024.04.032. Epub 2024 Jun 12.
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Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
Leon U B Enk, Malte Hellmig, Kristoffer Riecken, Christoph Kilian, Paul Datlinger, Saskia L Jauch-Speer, Tobias Neben, Zeba Sultana, Varshi Sivayoganathan, Alina Borchers, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Shuya Liu, Theodora Agalioti, Penelope Pelczar, Thorsten Wiech, Christoph Bock, Tobias B Huber, Samuel Huber, Stefan Bonn, Nicola Gagliani, Boris Fehse, Ulf Panzer, Christian F Krebs
Sci Immunol. 2024 Jun 14;9(96):eadd6774. doi: 10.1126/sciimmunol.add6774. Epub 2024 Jun 14.
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Monitoring subcellular protein localization at scale in live cells
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Reticulated platelets in cirrhosis - Just a surrogate for thrombocytopenia?
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Dig Liver Dis. 2024 Sep;56(9):1641-1642. doi: 10.1016/j.dld.2024.05.029. Epub 2024 Jun 8.
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Development of a live cell assay for the zinc transporter ZnT8
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SLAS Discov. 2024 Jul;29(5):100166. doi: 10.1016/j.slasd.2024.100166. Epub 2024 Jun 5.
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Single-cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation
Mathias Declercq, Lucas Treps, Vincent Geldhof, Nadine V Conchinha, Laura P M H de Rooij, Abhishek Subramanian, Magalie Feyeux, Marine Cotinat, Bram Boeckx, Stefan Vinckier, Lieven Dupont, Francois Vermeulen, Mieke Boon, Marijke Proesmans, Louis Libbrecht, Jacques Pirenne, Diethard Monbaliu, Ina Jochmans, Mieke Dewerchin, Guy Eelen, Tania Roskams, Stijn Verleden, Diether Lambrechts, Peter Carmeliet, Peter Witters
Liver Int. 2024 Sep;44(9):2382-2395. doi: 10.1111/liv.15963. Epub 2024 Jun 7.
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2024
Genomic surveillance of SARS-CoV-2 evolution by a centralised pipeline and weekly focused sequencing, Austria, January 2021 to March 2023
Olga Frank, David Acitores Balboa, Maria Novatchkova, Ezgi Özkan, Marcus Martin Strobl, Ramesh Yelagandula, Tanino Guiseppe Albanese, Lukas Endler, Fabian Amman, Vera Felsenstein, Milanka Gavrilovic, Melanie Acosta, Timothej Patocka, Alexander Vogt, Ido Tamir, Julia Klikovits, Alexander Zoufaly, Tamara Seitz, Manuela Födinger, Andreas Bergthaler, Alexander Indra, Daniela Schmid, Peter Klimek, Alexander Stark, Franz Allerberger, Bernhard Benka, Katharina Reich, Luisa Cochella, Ulrich Elling
Euro Surveill. 2024 Jun;29(23):2300542. doi: 10.2807/1560-7917.ES.2024.29.23.2300542.
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2024
EASL position paper on clinical follow-up after HCV cure
Thomas Reiberger, Sabela Lens, Giuseppe Cabibbo, Pierre Nahon, Anna Linda Zignego, Katja Deterding, Ahmed M Elsharkawy, Xavier Forns
J Hepatol. 2024 Aug;81(2):326-344. doi: 10.1016/j.jhep.2024.04.007. Epub 2024 Jun 6.
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The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
Cristiano De Sá Fernandes, Philipp Novoszel, Tommaso Gastaldi, Dana Krauß, Magdalena Lang, Ramona Rica, Ana P Kutschat, Martin Holcmann, Wilfried Ellmeier, Davide Seruggia, Herbert Strobl, Maria Sibilia
Cell Rep. 2024 Jun 25;43(6):114308. doi: 10.1016/j.celrep.2024.114308. Epub 2024 Jun 2.
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Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy
Gerlinde Karbon, Fabian Schuler, Vincent Z Braun, Felix Eichin, Manuel Haschka, Mathias Drach, Rocio Sotillo, Stephan Geley, Diana Cj Spierings, Andrea E Tijhuis, Floris Foijer, Andreas Villunger
EMBO Rep. 2024 Jun;25(6):2743-2772. doi: 10.1038/s44319-024-00160-3. Epub 2024 May 28.
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A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Kerstin Heindl, Stefanie Weiss, Thomas Eder, Sayantanee Dutta, Uwe Graichen, Sascha Klee, Omar Sharif, Rotraud Wieser, Balázs Győrffy, Valeria Poli, Emilio Casanova, Heinz Sill, Florian Grebien, Dagmar Stoiber
Cell Death Dis. 2024 May 28;15(5):369. doi: 10.1038/s41419-024-06749-9.
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AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells
Lars Hellweg, Martin Pfeifer, Miroslaw Tarnawski, Shao Thing-Teoh, Lena Chang, Andrea Bergner, Jana Kress, Julien Hiblot, Tabea Wiedmer, Giulio Superti-Furga, Jürgen Reinhardt, Kai Johnsson, Philipp Leippe
Cell Chem Biol. 2024 Aug 15;31(8):1529-1541.e12. doi: 10.1016/j.chembiol.2024.05.002. Epub 2024 May 27.
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Portal hypertension and its prognostic implications in patients with Wilson's disease
Lukas Burghart, Peter Ferenci, Oleksandr Petrenko, Mattias Mandorfer, Michael Schwarz, Michael Gschwantler, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer
Aliment Pharmacol Ther. 2024 Jul;60(2):257-266. doi: 10.1111/apt.18060. Epub 2024 May 26.
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Beyond the microscope: Unveiling bacterial vaginosis with AI-powered multiomics data analysis
Simona Saluzzo, Georg Stary
J Eur Acad Dermatol Venereol. 2024 Jun;38(6):999-1000. doi: 10.1111/jdv.20022.
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Breakthrough Infections in SARS-CoV-2-Vaccinated Multiple Myeloma Patients Improve Cross-Protection against Omicron Variants
Angelika Wagner, Erika Garner-Spitzer, Claudia Auer, Pia Gattinger, Ines Zwazl, René Platzer, Maria Orola-Taus, Peter Pichler, Fabian Amman, Andreas Bergthaler, Johannes B Huppa, Hannes Stockinger, Christoph C Zielinski, Rudolf Valenta, Michael Kundi, Ursula Wiedermann
Vaccines (Basel). 2024 May 9;12(5):518. doi: 10.3390/vaccines12050518.
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2024
In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods
Fanni Tóth, Zahra Moftakhar, Federica Sotgia, Michael P Lisanti
Cells. 2024 May 15;13(10):841. doi: 10.3390/cells13100841.
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Pan-cancer analysis of the interplay between mutational signatures and cellular signaling
Anna Hakobyan, Mathilde Meyenberg, Nelli Vardazaryan, Joel Hancock, Loan Vulliard, Joanna I Loizou, Jörg Menche
iScience. 2024 May 2;27(6):109873. doi: 10.1016/j.isci.2024.109873. eCollection 2024 Jun 21.
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Mapping the brain's gene-regulatory maze
Gaia Novarino, Christoph Bock
Science. 2024 May 24;384(6698):860-861. doi: 10.1126/science.adp4663. Epub 2024 May 23.
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The gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" category
Michaela Kotrova, Eva Fronkova, Michael Svaton, Daniela Drandi, Felix Schön, Patricia Hoogeveen, Jeremy Hancock, Aneta Skotnicova, Anke Schilhabel, Cornelia Eckert, Emmanuelle Clappier, Gianni Cazzaniga, Beat W Schäfer, Jacques J M van Dongen, Matthias Ritgen, Christiane Pott, Vincent H J van der Velden, Jan Trka, Monika Brüggemann
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Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins
Gary Tin, Marko Cigler, Matthias Hinterndorfer, Kevin D Dong, Hana Imrichova, Steven P Gygi, Georg E Winter
Bioorg Med Chem Lett. 2024 Jul 15;107:129779. doi: 10.1016/j.bmcl.2024.129779. Epub 2024 May 9.
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TLR 2 and CD14 Mediate Innate Immunity and Lung Inflammation to Staphylococcal Panton-Valentine Leukocidin In Vivo.
Zivkovic A, Sharif O, Stich K, Doninger B, Biaggio M, Colinge J, Bilban M, Mesteri I, Hazemi P, Lemmens-Gruber R, Knapp S
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4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice.
Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS
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PLoS One, 2009 Dec 16; 4(12):e8292.
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The GGCC haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation positive polycythemia vera.
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B15-42 protects against acid-induced acute lung injury and secondary Pseudomonas pneumonia in vivo.
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Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F.
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2024
RNA sequestration in P-bodies sustains myeloid leukaemia
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Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
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The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria.
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A novel homozygous RAG1 mutation is associated with severe combined immunodeficiency and neurological presentations.
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Impaired respiratory burst contributes to infections in PKCδ-deficient patients.
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Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease.
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Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation.
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Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.
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Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis.
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Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole A, Pereyaslov D, WHO European Region sequencing laboratories and GISAID EpiCoV group; WHO European Region sequencing laboratories and GISAID EpiCoV group*
Euro Surveill. 2020 Aug;25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
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2020
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Blood Adv. 2020 Aug 25;4(16):3971-3976. doi: 10.1182/bloodadvances.2020001786.
 
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2020
Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets.
Marquina-Sanchez B, Fortelny N, Farlik M, Vieira A, Collombat P, Bock C, Kubicek S
Genome Biol. 2020 May 6;21(1):106. doi: 10.1186/s13059-020-02006-2.
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2020
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs.
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Nat Chem Biol. 2020 Apr;16(4):469-478. doi: 10.1038/s41589-020-0483-3. Epub 2020 Mar 9.
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2019
Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.
Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A, Merkel A, Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH, Clarke L, Heath S, van der Reijden BA, Flicek P, Yaspo ML, Gut I,  Bock C, Schuringa JJ, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA
 Cell Rep. 2019;26(4):1059–1069.e6. doi:10.1016/j.celrep.2018.12.098
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2019
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica. 2019 Oct;104(10):1935-1949. doi: 10.3324/haematol.2019.222059.
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2019
CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks.
Uras IZ, Maurer B, Nivarthi H, Jodl P, Kollmann K, Prchal-Murphy M, Milosevic Feenstra JD, Zojer M, Lagger S, Grausenburger R, Grabner B, Holly R, Kavirayani A,  Bock C, Gisslinger H, Valent P, Kralovics R, Sexl V
 Blood. 2019;133(15):1677–1690. doi:10.1182/blood-2018-08-872648
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2019
Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer.
Unterleuthner D, Neuhold P, Schwarz K, Janker L, Neuditschko B, Nivarthi H, Crncec I, Kramer N, Unger C, Hengstschläger M, Eferl R, Moriggl R, Sommergruber W, Gerner C, Dolznig H
Angiogenesis. 2019 Oct 30. doi: 10.1007/s10456-019-09688-8.
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2019
Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities.
Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M, Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G, Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF, Schild S, Högenauer C, Zechner EL
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi: 10.1073/pnas.1819154116.
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Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection.
Ulz P, Perakis S, Zhou Q, Moser T, Belic J, Lazzeri I, Wölfler A, Zebisch A, Gerger A, Pristauz G, Petru E, White B, Roberts CES, John JS, Schimek MG, Geigl JB, Bauernhofer T, Sill H,  Bock C, Heitzer E, Speicher MR
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2019
Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score.
Tesch VK, Abolhassani H, Shadur B, Zobel J, Mareika Y, Sharapova S, Karakoc-Aydiner E, Rivière JG, Garcia-Prat M, Moes N, Haerynck F, Gonzales-Granado LI, Santos Pérez JL, Mukhina A, Shcherbina A, Aghamohammadi A, Hammarström L, Dogu F, Haskologlu S, İkincioğulları AI, Bal SK, Baris S, Kilic SS, Karaca NE, Kutukculer N, Girschick H, Kolios A, Keles S, Uygun V, Stepensky P, Worth A, van Montfrans JM, Peters AMJ, Meyts I, Adeli M, Marzollo A, Padem N, Khojah AM, Chavoshzadeh Z, Stefanija MA, Bakhtiar S, Florkin B, Meeths M, Gamez L, Grimbacher B, Seppänen MR, Lankester A, Gennery AR, Seidel MG; Inborn Errors, Clinical, and Registry Working Parties of the European Society for Blood and Marrow Transplantation (EBMT) and the European Society of Immunodeficiencies (ESID)
J Allergy Clin Immunol. 2019 Dec 27. pii: S0091-6749(19)32603-X. doi: 10.1016/j.jaci.2019.12.896.
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2019
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P
Mol Cell. 2019 Nov 7;76(3):485-499.e8. doi: 10.1016/j.molcel.2019.07.034.
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CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.
Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K
Blood. 2019 Oct 31;134(18):1510-1516. doi: 10.1182/blood.2019000644.
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Klufa J, Bauer T, Hanson B, et al.
Klufa J, Bauer T, Hanson B, Herbold C, Starkl P, Lichtenberger B, Srutkova D, Schulz D, Vujic I, Mohr T, Rappersberger K, Bodenmiller B, Kozakova H,  Knapp S, Loy A, Sibilia M
Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy. Sci Transl Med. 2019;11(522):eaax2693. doi:10.1126/scitranslmed.aax2693
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2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Kiss MG, Ozsvár-Kozma M, Porsch F, Göderle L, Papac-Miličević N, Bartolini-Gritti B, Tsiantoulas D, Pickering MC,  Binder CJ
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2019
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
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2019
Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions.
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Int J Hematol. 2019 Nov 18. doi: 10.1007/s12185-019-02778-9.
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Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease.
Houben T, Magro Dos Reis I, Oligschlaeger Y, Steinbusch H, Gijbels MJJ, Hendrikx T, Binder CJ, Cassiman D, Westerterp M, Prickaerts J, Shiri-Sverdlov R
Front Immunol. 2019 Jan 7;9:3089. doi: 10.3389/fimmu.2018.03089. eCollection 2018.
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2019
Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis.
Halbritter F, Farlik M, Schwentner R, Jug G, Fortelny N, Schnöller T, Pisa H, Schuster LC, Reinprecht A, Czech T, Gojo J, Holter W, Minkov M, Bauer W, Simonitsch-Klupp I, Bock C, Hutter C
Cancer Discov. 2019 Oct;9(10):1406-1421. doi: 10.1158/2159-8290.CD-19-0138.
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Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
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Nat Commun. 2019 Dec 6;10(1):5573. doi: 10.1038/s41467-019-13348-2.
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2019
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.
Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, Maurer-Granofszky M, Roka F, Penz T,  Bock C, Zhang G, Herlyn M, Glatz K, Läubli H, Mertz KD, Petzelbauer P, Wiesner T, Hartl M, Pickl WF, Somasundaram R, Steinberger P, Wagner SN
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2019
Sphingolipid-dependent Dscam sorting regulates axon segregation.
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2019
Unreported Missense Mutation in the Dimerization Domain of ADA2 Leads to ADA2 Deficiency Associated with Severe Oral Ulcers and Neutropenia in a Female Somalian Patient-Addendum to the Genotype-Phenotype Puzzle.
Göschl L, Winkler S, Dmytrus J, Heredia RJ, Lagler H, Ramharter M, Scheinecker C, Bonelli M, Schmetterer K, Pickl WF, Grabmeier-Pfistershammer K, Hershfield MS, Boztug K, Förster-Waldl E, Gualdoni GA
J Clin Immunol. 2019 Nov 4. doi: 10.1007/s10875-019-00700-w.
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2019
Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis.
Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih H-Y, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M
 J Autoimmun. 2019;102379. doi:10.1016/j.jaut.2019.102379
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2019
Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.
Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI
Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
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2019
Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders.
Downes K, Megy K, Duarte D, Vries M, Gebhart J, Hofer S, Shamardina O, Deevi SVV, Stephens J, Mapeta R, Tuna S, Al Hasso N, Besser MW, Cooper N, Daugherty L, Gleadall N, Greene D, Haimel M, Martin H, Papadia S, Revel-Vilk S, Sivapalaratnam S, Symington E, Thomas W, Thys C, Tolios A, Penkett CJ; NIHR BioResource, Ouwehand WH, Abbs S, Laffan MA, Turro E, Simeoni I, Mumford AD, Henskens YMC, Pabinger I, Gomez K, Freson K
Blood. 2019 Dec 5;134(23):2082-2091. doi: 10.1182/blood.2018891192.
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2019
Heterologous expression of the mammalian sodium-nucleobase transporter rSNBT1 in Leishmania tarentolae.
Doukas A, Karena E, Botou M, Papakostas K, Papadaki A, Tziouvara O, Xingi E, Frillingos S, Boleti H
Biochim Biophys Acta Biomembr. 2019 Sep 1;1861(9):1546-1557. doi: 10.1016/j.bbamem.2019.07.001.
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Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.
Di Giacomo AM, Covre A, Finotello F, Rieder D, Danielli R, Sigalotti L, Giannarelli D, Petitprez F, Lacroix L, Valente M, Cutaia O, Fazio C, Amato G, Lazzeri A, Monterisi S, Miracco C, Coral S, Anichini A,  Bock C, Nemc A, Oganesian A, Lowder J, Azab M, Fridman WH, Sautès-Fridman C, Trajanoski Z, Maio M
Clin Cancer Res. 2019;25(24):7351–7362. doi:10.1158/1078-0432.CCR-19-1335
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2019
Cell-Cycle Cross Talk with Caspases and Their Substrates.
Connolly P, Garcia-Carpio I, Villunger A
Cold Spring Harb Perspect Biol. 2019 Nov 14. pii: a036475. doi: 10.1101/cshperspect.a036475.
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2019
Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress.
Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K
J Clin Invest. 2019 Oct 1;129(10):4194-4206. doi: 10.1172/JCI128903.
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2019
Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice.
Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH,  Binder CJ, Kaser A, Mallat Z
 Circ Res. 2019;125(11):1019–1034. doi:10.1161/CIRCRESAHA.119.315248
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The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway.
Chien J, Wolf FW, Grosche S, Yosef N, Garriga G, Mörck C
Genetics. 2019 Dec;213(4):1465-1478. doi: 10.1534/genetics.119.302628.
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A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants.
Chen Y, Coussanes G, Souris C, Aillard P, Kaldre D, Runggatscher K, Kubicek S, Di Mauro G, Maryasin B, Maulide N
J Am Chem Soc. 2019 Sep 4;141(35):13772-13777. doi: 10.1021/jacs.9b07185.
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2019
Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R1, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG
Circulation. 2019 May 21;139(21):2466-2482. doi: 10.1161/CIRCULATIONAHA.118.038534.
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Mapping the perturbome network of cellular perturbations.
Caldera M, Müller F, Kaltenbrunner I, Licciardello MP, Lardeau CH, Kubicek S, Menche J
Nat Commun. 2019 Nov 13;10(1):5140. doi: 10.1038/s41467-019-13058-9.
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2019
A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects.
Cagdas D, Halaçlı SO, Tan Ç, Lo B, Çetinkaya PG, Esenboğa S, Karaatmaca B, Matthews H, Balcı-Hayta B, Arıkoğlu T, Ezgü F, Aladağ E, Saltık-Temizel İN, Demir H, Kuşkonmaz B, Okur V, Gümrük F, Göker H, Çetinkaya D, Boztuğ K, Lenardo M, Sanal Ö, Tezcan İ
J Clin Immunol. 2019 Oct;39(7):726-738. doi: 10.1007/s10875-019-00677-6.
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2019
8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.
Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen S1
J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294.
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2019
Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis.
Bösl K, Ianevski A, Than TT, Andersen PI, Kuivanen S, Teppor M, Zusinaite E, Dumpis U, Vitkauskiene A, Cox RJ, Kallio-Kokko H, Bergqvist A, Tenson T, Merits A, Oksenych V, Bjørås M, Anthonsen MW, Shum D, Kaarbø M, Vapalahti O, Windisch MP, Superti-Furga G, Snijder B, Kainov D, Kandasamy RK
Front Immunol. 2019 Oct 4;10:2186. doi: 10.3389/fimmu.2019.02186.
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Barthel FP, Johnson KC, Varn FS, et al.
Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R,  Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW; GLASS Consortium
Longitudinal molecular trajectories of diffuse glioma in adults. Nature. 2019;576(7785):112–120. doi:10.1038/s41586-019-1775-1
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Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells.
Bier J, Rao G, Payne K, Brigden H, French E, Pelham SJ, Lau A, Lenthall H, Edwards ESJ, Smart JM, Cole TS, Choo S, Joshi AY, Abraham RS, O'Sullivan M, Boztug K, Meyts I, Gray PE, Berglund LJ, Hsu P, Wong M, Holland SM, NotarangeloLD, Uzel G, Ma CS, Brink R, Tangye SG, Deenick EK
JAllergy Clin Immunol. 2019 Jul;144(1):236-253. doi: 10.1016/j.jaci.2019.01.033.Epub 2019 Feb 6.
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2019
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferon response in RA-FLSs.
Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B, Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP, Karonitsch T
Exp Mol Med. 2019 Jul 8;51(7):75. doi:10.1038/s12276-019-0267-6.
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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE
Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi:10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.
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Stick it to E3s.
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Nat Chem Biol. 2019 Jul;15(7):655-656.doi: 10.1038/s41589-019-0312-8.
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Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies.
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Methods Mol Biol. 2019;1953:105-119. doi:10.1007/978-1-4939-9145-7_7.
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F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.
Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, NotarangeloLD
J Allergy Clin Immunol. 2019Jun;143(6):2317-2321.e12. doi: 10.1016/j.jaci.2019.02.014. Epub 2019 Feb 26.
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Activating PIK3CD mutations impair human cytotoxiclymphocyte differentiation and function and EBV immunity.
Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A, Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, DeenickEK, Uzel G, Tangye SG
J Allergy Clin Immunol.2019 Jan;143(1):276-291.e6. doi: 10.1016/j.jaci.2018.04.030. Epub 2018 May 22.
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Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency.
Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, SchuetzC, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C, Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG, Lycopoulou L, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, DbaiboG, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM, Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C, Wolska-Kuśnierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, ChandrakasanS, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O, Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B, Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR, Notarangelo LD, Walter JE
J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1970-1985.e4. doi: 10.1016/j.jaip.2019.02.038. Epub 2019 Mar 12.
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2019
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G
Cell Death Differ. 2019Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20.
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MicroRNA-155 Controls T Helper Cell Activation During Viral Infection.
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Front Immunol. 2019 Jun 13;10:1367. doi:10.3389/fimmu.2019.01367. eCollection 2019.
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Growth dynamics in naturally progressing chronic lymphocytic leukaemia.
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Nature. 2019 Jun;570(7762):474-479.doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.
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A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52.
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HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.
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Gastroenterology. 2019 Jun;156(8):2313-2329.e7.doi: 10.1053/j.gastro.2019.02.038. Epub 2019 Mar 2.
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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.
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NatCommun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. PubMed PMID:30626869;
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Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
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Hematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement? J Pediatr Hematol Oncol.
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The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.
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Drug Discov Today Technol. 2019Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.
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SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.
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The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.
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Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development.
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The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells.
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The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
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Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL.
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Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics.
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Ann Hematol. 2019 May;98(5):1111-1118. doi:10.1007/s00277-018-3570-8. Epub 2018 Dec 8.
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BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation.
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Clin Cancer Res. 2019 Mar 15;25(6):1901-1912. doi:10.1158/1078-0432.CCR-18-1548. Epub 2018 Nov 28.
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CD8(+) T cells induce cachexia during chronic viral infection.
Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, AliA, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A
Nat Immunol. 2019Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID:31110314;
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House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
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Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers.
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Synthetic Lethal Interactions for Kinase Deficiencies to DNA Damage Chemotherapeutics.
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Cancer Res. 2019 Nov 15;79(22):5693-5698. doi: 10.1158/0008-5472.CAN-19-1364.
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Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells.
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Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells.
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Neoplasma. 2019 May 23;66(3):357-366. doi: 10.4149/neo_2018_180731N560.
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Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
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Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001.
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Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.
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Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
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Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.
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Platelet PI3K Modulates Innate Leukocyte Extravasation during Acid-Induced Acute Lung Inflammation.
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Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants [published online ahead of print, 2019 Nov 21].
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B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses.
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Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi:10.1161/ATVBAHA.118.312272. Epub 2019 May 16.
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Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants.
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Blood. 2019 Jun 20;133(25):2669-2681. doi:10.1182/blood-2018-09-874578. Epub 2019 Mar 22.
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Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells.
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Circ Res. 2019 Jun 21;125(1):43-52. doi:10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8.
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Glucocorticoid Receptor-Deficient Foxp3(+) Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.
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Nat Rev Cardiol. 2019 Mar;16(3):180-196. doi:10.1038/s41569-018-0106-9. Review.
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Insights into the transport side of the human SLC38A9 transceptor.
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PD-L1 and PD1 expression in post-transplantation lymphoproliferative disease (PTLD) of childhood and adolescence: An inter- and intra-individual descriptive study covering the whole spectrum of PTLD categories.
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Cancer Med. 2019 Jul 3. doi: 10.1002/cam4.2394. [Epub ahead of print]
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Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.
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Blood. 2019 Jul 11;134(2):199-210. doi: 10.1182/blood.2019000519. Epub2019 May 7.
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Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL.
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MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation.
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Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
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Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
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A Novel Recessive Mutation of Interferon-γ Receptor 1 in a Patient with Mycobacterium tuberculosis in Bone Marrow Aspirate.
Shabani M, Aleyasin S, Kashef S, Zoghi S, Deswarte C, Casanova JL, BustamanteJ, Rezaei N
J Clin Immunol. 2019Feb;39(2):127-130. doi: 10.1007/s10875-019-00595-7. Epub 2019 Feb 5.
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Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function.
Shahin T, Aschenbrenner D, Cagdas D, Bal SK, Conde CD, Garncarz W, MedgyesiD, Schwerd T, Karaatmaca B, Cetinkaya PG, Esenboga S, Twigg SRF, Cant A, WilkieAOM, Tezcan I, Uhlig HH, Boztug K
Haematologica. 2019 Mar;104(3):609-621. doi:10.3324/haematol.2018.194233. Epub 2018 Oct 11.
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NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B
J Immunol. 2019 Mar 15;202(6):1724-1734. doi: 10.4049/jimmunol.1701649.Epub 2019 Feb 4.
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Singh DD, Hawkins RD, Lahesmaa R, Tripathi SK
Semin Cell Dev Biol. 2019 Jun 19. pii: S1084-9521(18)30111-3. doi:10.1016/j.semcdb.2019.05.007. [Epub ahead of print] Review.
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Int J Mol Sci. 2019 Feb 27;20(5). pii: E1029. doi:10.3390/ijms20051029. Review.
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Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I
Science. 2019 Jun 7;364(6444). pii: eaas9536. doi:10.1126/science.aas9536.
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Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED
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Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia (T-PLL).
Staber PB, Herling M, Bellido M, Jacobsen ED, Davids MS, Kadia TM, Shustov A, Tournilhac O, Bachy E, Zaja F, Porkka K, Hoermann G, Simonitsch I, Haferlach C, Kubicek S, Mayerhoefer M, Hopfinger G, Jaeger U, Dearden C
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Integrative Proteomic Profiling RevealsPRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.
van Mierlo G, Dirks RAM, De Clerck L, Brinkman AB, Huth M, Kloet SL, Saksouk N, Kroeze LI, Willems S, Farlik M, Bock C, Jansen JH, Deforce D, Vermeulen M, Déjardin J, Dhaenens M, Marks H
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2018
Exome sequencing revealed C1Q homozygous mutation in Pediatric Systemic Lupus Erythematosus.
Zoghi S, Ziaee V, Hirschmugl T, Jimenez-Heredia R, Krolo A, Boztug K, Rezaei N
Allergol Immunopathol (Madr). 2018 Nov - Dec;46(6):594-598. doi: 10.1016/j.aller.2018.02.004. Epub 2018 May 5.
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NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3.
Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F
J Virol. 2018 Nov 12;92(23). pii: e01202-18. doi: 10.1128/JVI.01202-18. Print 2018 Dec 1.
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Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo.
Verger E, Soret-Dulphy J, Maslah N, Roy L, Rey J, Ghrieb Z, Kralovics R, Gisslinger H, Grohmann-Izay B, Klade C, Chomienne C, Giraudier S, Cassinat B, Kiladjian JJ
Blood Cancer J. 2018 Oct 4;8(10):94. doi: 10.1038/s41408-018-0133-0.
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Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.
Tsafou K, Katschnig AM, Radic-Sarikas B, Mutz CN, Iljin K, Schwentner R, Kauer MO, Mühlbacher K, Aryee DNT, Westergaard D, Haapa-Paananen S, Fey V, Superti-Furga G, Toretsky J, Brunak S, Kovar H
Oncotarget. 2018 Jul 24;9(57):31018-31031. doi: 10.18632/oncotarget.25760. eCollection 2018 Jul 24.
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J Cell Sci. 2018 Aug 3;131(15). pii: jcs216259. doi: 10.1242/jcs.216259. Review. .
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Novel Mutation in CECR1 Leads to Deficiency of ADA2 with Associated Neutropenia.
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J Clin Immunol. 2018 Apr;38(3):273-277. doi: 10.1007/s10875-018-0487-x. Epub 2018 Mar 21.
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Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines.
Lee SE, Song J, Bösl K, Müller AC, Vitko D, Bennett KL, Superti-Furga G, Pandey A, Kandasamy RK, Kim MS
Proteomics. 2018 Apr;18(8):e1700386. doi: 10.1002/pmic.201700386.
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MIRA: An R package for DNA methylation-based inference of regulatory activity.
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Bioinformatics. 2018 Mar 1. doi: 10.1093/bioinformatics/bty083. [Epub ahead of print]
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Chromothripsis in acute myeloid leukemia: biological features and impact on survival.
Fontana MC, Marconi G, Feenstra JDM, Fonzi E, Papayannidis C, Ghelli Luserna di Rorá A, Padella A, Solli V, Franchini E, Ottaviani E, Ferrari A, Baldazzi C, Testoni N, Iacobucci I, Soverini S, Haferlach T, Guadagnuolo V, Semerad L, Doubek M, Steurer M, Racil Z, Paolini S, Manfrini M, Cavo M, Simonetti G, Kralovics R, Martinelli G
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Pharmacologic inhibition of STAT5 in acute myeloid leukemia.
Wingelhofer B, Maurer B, Heyes EC, Cumaraswamy AA, Berger-Becvar A, de Araujo ED, Orlova A, Freund P, Ruge F, Park J, Tin G, Ahmar S, Lardeau CH, Sadovnik I, Bajusz D, Keserű GM, Grebien F, Kubicek S, Valent P, Gunning PT, Moriggl R
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Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.
Lowe R, Barton C, Jenkins CA, Ernst C, Forman O, Fernandez-Twinn DS, Bock C, Rossiter SJ, Faulkes CG, Ozanne SE, Walter L, Odom DT, Mellersh C, Rakyan VK
Genome Biol. 2018 Feb 16;19(1):22. doi: 10.1186/s13059-018-1397-1.
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2018
Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring.
Skjærven KH, Jakt LM, Fernandes JMO, Dahl JA, Adam AC, Klughammer J, Bock C, Espe M
Sci Rep. 2018 Feb 14;8(1):3055. doi: 10.1038/s41598-018-21211-5.
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Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity.
Clément M, Haddad Y, Raffort J, Lareyre F, Newland SA, Master L, Harrison J, Ozsvar-Kozma M, Bruneval P, Binder CJ, Taleb S, Mallat Z
Circ Res. 2018 Mar 16;122(6):813-820. doi: 10.1161/CIRCRESAHA.118.312713. Epub 2018 Feb 7.
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Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium.
Aldape K, Amin SB, Ashley DM, Barnholtz-Sloan JS, Bates AJ, Beroukhim R, Bock C, Brat DJ, Claus EB, Costello JF, de Groot JF, Finocchiaro G, French PJ, Gan HK, Griffith B, Herold-Mende CC, Horbinski C, Iavarone A, Kalkanis SN, Karabatsou K, Kim H, Kouwenhoven MCM, McDonald KL, Miletic H, Nam DH, Ng HK, Niclou SP, Noushmehr H, Ormond R, Poisson LM, Reifenberger G, Roncaroli F, Sa JK, Sillevis Smitt PAE, Smits M, Souza CF, Tabatabai G, Van Meir EG, Verhaak RGW, Watts C, Wesseling P, Woehrer A, Yung WKA, Jungk C, Hau AC, van Dyck E, Westerman BA, Yin J, Abiola O, Zeps N, Grimmond S, Buckland M, Khasraw M, Sulman EP, Muscat AM, Stead L; GLASS Consortium
Neuro Oncol. 2018 Feb 8. doi: 10.1093/neuonc/noy020. [Epub ahead of print]
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Human NF-κB1 Haploinsufficiency and Epstein-Barr Virus-Induced Disease-Molecular Mechanisms and Consequences.
Hoeger B, Serwas NK, Boztug K
Front Immunol. 2018 Jan 18;8:1978. doi: 10.3389/fimmu.2017.01978. eCollection 2017. Review.
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Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jimenez-Agüero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O, Mann DA
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Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules.
Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe C
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Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.
Afonyushkin T, Oskolkova OV, Bochkov VN
Angiogenesis. 2018 May;21(2):229-236. doi: 10.1007/s10456-017-9590-5. Epub 2018 Jan 12. PubMed PMID: 29330760; PubMed Central PMCID: PMC5878191.
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2018
Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.
Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, Bauer S, Erb MA, Parapatics K, Müller AC, Bennett KL, Ecker GF, Bradner JE, Winter GE
ACS Chem Biol. 2018 Mar 16;13(3):553-560. doi: 10.1021/acschembio.7b00969. Epub 2018 Jan 29.
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SETD2 in MLL-rearranged leukemia - a complex case.
Skucha A, Ebner J, Grebien F
Mol Cell Oncol. 2018 Aug 13;5(4):e1503492. doi: 10.1080/23723556.2018.1503492. eCollection 2018.
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Monogenic Diabetes Not Caused By Mutations in Mody Genes: A Very Heterogenous Group of Diabetes.
Şıklar Z, de Franco E, Johnson MB, Flanagan SE, Ellard S, Ceylaner S, Boztuğ K, Doğu F, İkincioğulları A, Kuloğlu Z, Kansu A, Berberoğlu M
Exp Clin Endocrinol Diabetes. 2018 Nov;126(10):612-618. doi: 10.1055/s-0043-120571. Epub 2017 Nov 28.
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2018
Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module.
Sharma A, Kitsak M, Cho MH, Ameli A, Zhou X, Jiang Z, Crapo JD, Beaty TH, Menche J, Bakke PS, Santolini M, Silverman EK
Sci Rep. 2018 Sep 27;8(1):14439. doi: 10.1038/s41598-018-32173-z.
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Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.
Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J
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The Phenotype and Treatment of WIP Deficiency: Literature Synopsis and Review of a Patient With Pre-transplant Serial Donor Lymphocyte Infusions to Eliminate CMV.
Schwinger W, Urban C, Ulreich R, Sperl D, Karastaneva A, Strenger V, Lackner H, Boztug K, Albert MH, Benesch M, Seidel MG
Front Immunol. 2018 Nov 2;9:2554. doi: 10.3389/fimmu.2018.02554. eCollection 2018. Review.
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Ldlr(-)(/)(-) and ApoE(-)(/)(-) mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.
Saulnier-Blache JS, Wilson R, Klavins K, Graham D, Alesutan I, Kastenmüller G, Wang-Sattler R, Adamski J, Roden M, Rathmann W, Seissler J, Meisinger C, Koenig W, Thiery J, Suhre K, Peters A, Kuro-O M, Lang F, Dallmann G, Delles C, Voelkl J, Waldenberger M, Bascands JL, Klein J, Schanstra JP
Atherosclerosis. 2018 Sep;276:140-147. doi: 10.1016/j.atherosclerosis.2018.07.024. Epub 2018 Jul 21.
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R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome.
Sarkar K, Han SS, Wen KK, Ochs HD, Dupré L, Seidman MM, Vyas YM
J Allergy Clin Immunol. 2018 Jul;142(1):219-234. doi: 10.1016/j.jaci.2017.11.023. Epub 2017 Dec 15.
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The role of B cells in atherosclerosis.
Sage AP, Tsiantoulas D, Binder CJ, Mallat Z
Nat Rev Cardiol. 2018 Nov 8. doi: 10.1038/s41569-018-0106-9. [Epub ahead of print] Review.
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2018
Thoracic Actinomycosis With Infiltration of the Spine: An Oncological Pitfall.
Ronceray L, Friesenbichler W, Hutter C, Lakatos K, Krizmanich W, Amann G, Boztug K, Kager L, Mann G, Attarbaschi A
J Pediatr Hematol Oncol. 2018 Aug;40(6):468-471. doi: 10.1097/MPH.0000000000001035.
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2018
Non-classical monocytes as mediators of tissue destruction in arthritis.
Puchner A, Saferding V, Bonelli M, Mikami Y, Hofmann M, Brunner JS, Caldera M, Goncalves-Alves E, Binder NB, Fischer A, Simader E, Steiner CW, Leiss H, Hayer S, Niederreiter B, Karonitsch T, Koenders MI, Podesser BK, O'Shea JJ, Menche J, Smolen JS, Redlich K, Blüml S
Ann Rheum Dis. 2018 Oct;77(10):1490-1497. doi: 10.1136/annrheumdis-2018-213250. Epub 2018 Jun 29.
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2018
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Porpaczy E, Tripolt S, Hoelbl-Kovacic A, Gisslinger B, Bago-Horvath Z, Casanova-Hevia E, Clappier E, Decker T, Fajmann S, Fux DA, Greiner G, Gueltekin S, Heller G, Herkner H, Hoermann G, Kiladjian JJ, Kolbe T, Kornauth C, Krauth MT, Kralovics R, Muellauer L, Mueller M, Prchal-Murphy M, Putz EM, Raffoux E, Schiefer AI, Schmetterer K, Schneckenleithner C, Simonitsch-Klupp I, Skrabs C, Sperr WR, Staber PB, Strobl B, Valent P, Jaeger U, Gisslinger H, Sexl V
Blood. 2018 Aug 16;132(7):694-706. doi: 10.1182/blood-2017-10-810739. Epub 2018 Jun 14.
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2018
Recent advances in combinatorial drug screening and synergy scoring.
Pemovska T, Bigenzahn JW, Superti-Furga G
Curr Opin Pharmacol. 2018 Oct;42:102-110. doi: 10.1016/j.coph.2018.07.008. Epub 2018 Sep 5. Review.
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2018
Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R
Oncotarget. 2018 Sep 18;9(73):33865. doi: 10.18632/oncotarget.26156. eCollection 2018 Sep 18.
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2018
The Tubulin Detyrosination Cycle: Function and Enzymes.
Nieuwenhuis J, Brummelkamp TR
Trends Cell Biol. 2018 Sep 10. pii: S0962-8924(18)30141-7. doi: 10.1016/j.tcb.2018.08.003. [Epub ahead of print] Review.
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2018
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G
Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013.
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2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César-Razquin A, Stukalov A, Vittori S, Muhar M, Lu B, Aichinger M, Jude J, Müller AC, Győrffy B, Vakoc CR, Valent P, Bennett KL, Zuber J, Superti-Furga G, Grebien F
Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y.
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2018
mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation.
Cell Rep. 2018 May 15;23(7):2157-2167. doi: 10.1016/j.celrep.2018.04.044.
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2018
Mutations affecting the actin regulator WDR1 lead to aberrant lymphoid immunity.
Pfajfer L, Mair NK, Jiménez-Heredia R, Genel F, Gulez N, Ardeniz Ö, Hoeger B, Bal SK, Madritsch C, Kalinichenko A, Chandra Ardy R, Gerçeker B, Rey-Barroso J, Ijspeert H, Tangye SG, Simonitsch-Klupp I, Huppa JB, van der Burg M, Dupré L, Boztug K
J Allergy Clin Immunol. 2018 May 8. pii: S0091-6749(18)30694-8. doi: 10.1016/j.jaci.2018.04.023. [Epub ahead of print]
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2018
Exome sequencing revealed C1Q homozygous mutation in Pediatric Systemic Lupus Erythematosus.
Zoghi S, Ziaee V, Hirschmugl T, Jimenez-Heredia R, Krolo A, Boztug K, Rezaei N
Allergol Immunopathol (Madr). 2018 May 5. pii: S0301-0546(18)30047-8. doi: 10.1016/j.aller.2018.02.004. [Epub ahead of print]
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2018
ADA Deficiency: Evaluation of the Clinical and Laboratory Features and the Outcome.
Cagdas D, Gur Cetinkaya P, Karaatmaca B, Esenboga S, Tan C, Yılmaz T, Gümüş E, Barış S, Kuşkonmaz B, Ozgur TT, Bali P, Santisteban I, Orhan D, Yüce A, Cetinkaya D, Boztug K, Hershfield M, Sanal O, Tezcan İ
J Clin Immunol. 2018 May 9. doi: 10.1007/s10875-018-0496-9. [Epub ahead of print]
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Hematopoietic Stem Cell Transplantation From Unrelated Donors in 2 Cases of Interleukin-10 Receptor Deficiency: Is Surgery Not a Requirement? J Pediatr Hematol Oncol.
Kocacik Uygun DF, Uygun V, Daloğlu H, Öztürkmen S, Karasu G, Reisli İ, Sayar E, Yüksekkaya HA, Glocker EO, Boztuğ K, Yeşilipek A
2018 Apr 20. doi: 10.1097/MPH.0000000000001165. [Epub ahead of print]
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2018
Validating the concept of mutational signatures with isogenic cell models.
Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S
Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8.
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2018
KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.
Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR
Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19.
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2018
CEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils.
Serwas NK, Huemer J, Dieckmann R, Mejstrikova E, Garncarz W, Litzman J, Hoeger B, Zapletal O, Janda A, Bennett KL, Kain R, Kerjaschky D, Boztug K
Front Immunol. 2018 Mar 29;9:588. doi: 10.3389/fimmu.2018.00588. eCollection 2018.
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2018
Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency.
van Rijn JM, Chandra Ardy R, Kuloğlu Z, Härter B, van Haaften-Visser DY, van der Doef HPJ, van Hoesel M, Kansu A, van Vugt AHM, Ng M, Kokke FTM, Krolo A, Başaran MK, Kaya NG, Aksu AÜ, Dalgıç B, Ozcay F, Baris Z, Kain R, Stigter ECA, Lichtenbelt KD, Massink MPG, Duran KJ, Verheij JBGM, Lugtenberg D, Nikkels PGJ, Brouwer HGF, Verkade HJ, Scheenstra R, Spee B, Nieuwenhuis EES, Coffer PJ, Janecke AR, van Haaften G, Houwen RHJ, Müller T, Middendorp S, Boztug K
Gastroenterology. 2018 Mar 29. pii: S0016-5085(18)30347-0. doi: 10.1053/j.gastro.2018.03.040. [Epub ahead of print]
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2018
Lymphatic exosomes promote dendritic cell migration along guidance cues.
Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D
J Cell Biol. 2018 Jun 4;217(6):2205-2221. doi: 10.1083/jcb.201612051. Epub 2018 Apr 12.
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2018
The dTAG system for immediate and target-specific protein degradation.
Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE
Nat Chem Biol. 2018 May;14(5):431-441. doi: 10.1038/s41589-018-0021-8. Epub 2018 Mar 26.
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2018
Human tripartite motif protein 52 is required for cell context-dependent proliferation.
Benke S, Agerer B, Haas L, Stöger M, Lercher A, Gabler L, Kiss I, Scinicariello S, Berger W, Bergthaler A, Obenauf AC, Versteeg GA
Oncotarget. 2018 Feb 5;9(17):13565-13581. doi: 10.18632/oncotarget.24422. eCollection 2018 Mar 2.
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2018
Approaches to target IgE antibodies in allergic diseases.
Balbino B, Conde E, Marichal T, Starkl P, Reber LL
Pharmacol Ther. 2018 Nov;191:50-64. doi: 10.1016/j.pharmthera.2018.05.015. Epub 2018 Jun 27. Review.
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2018
Germline-activating mutations in PIK3CD compromise B cell development and function.
Avery DT, Kane A, Nguyen T, Lau A, Nguyen A, Lenthall H, Payne K, Shi W, Brigden H, French E, Bier J, Hermes JR, Zahra D, Sewell WA, Butt D, Elliott M, Boztug K, Meyts I, Choo S, Hsu P, Wong M, Berglund LJ, Gray P, O'Sullivan M, Cole T, Holland SM, Ma CS, Burkhart C, Corcoran LM, Phan TG, Brink R, Uzel G, Deenick EK, Tangye SG
J Exp Med. 2018 Aug 6;215(8):2073-2095. doi: 10.1084/jem.20180010. Epub 2018 Jul 17.
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2018
Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology.
Aguirre-Plans J, Piñero J, Menche J, Sanz F, Furlong LI, Schmidt HHHW, Oliva B, Guney E
Pharmaceuticals (Basel). 2018 Jun 22;11(3). pii: E61. doi: 10.3390/ph11030061.
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2018
MHC class II deficiency: Report of a novel mutation and special review.
Farrokhi S, Shabani M, Aryan Z, Zoghi S, Krolo A, Boztug K, Rezaei N
Allergol Immunopathol (Madr). 2018 May - Jun;46(3):263-275. doi: 10.1016/j.aller.2017.04.006. Epub 2017 Jul 1. Review.
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2018
Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status.
Kubesova B, Pavlova S, Malcikova J, Kabathova J, Radova L, Tom N, Tichy B, Plevova K, Kantorova B, Fiedorova K, Slavikova M, Bystry V, Kissova J, Gisslinger B, Gisslinger H, Penka M, Mayer J, Kralovics R, Pospisilova S, Doubek M
Leukemia. 2018 Feb;32(2):450-461. doi: 10.1038/leu.2017.230. Epub 2017 Jul 24.
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2018
CDK6 antagonizes p53-induced responses during tumorigenesis.
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V
Cancer Discov. 2018 Jun 13. pii: CD-17-0912. doi: 10.1158/2159-8290.CD-17-0912. [Epub ahead of print]
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2018
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.
Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI
Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.
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2018
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbit CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S
Arterioscler Thromb Vasc Biol. 2018 Jun 7. pii: ATVBAHA.118.310802. doi: 10.1161/ATVBAHA.118.310802. [Epub ahead of print]
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2018
Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.
Simovski B, Kanduri C, Gundersen S, Titov D, Domanska D, Bock C, Bossini-Castillo L, Chikina M, Favorov A, Layer RM, Mironov AA, Quinlan AR, Sheffield NC, Trynka G, Sandve GK
Nucleic Acids Res. 2018 Jun 5. doi: 10.1093/nar/gky474. [Epub ahead of print]
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2018
BAFF Neutralization Aggravates Atherosclerosis.
Tsiantoulas D, Sage AP, Göderle L, Ozsvar-Kozma M, Murphy D, Porsch F, Pasterkamp G, Menche J, Schneider P, Mallat Z, Binder CJ
Circulation. 2018 Jun 1. pii: CIRCULATIONAHA.117.032790. doi: 10.1161/CIRCULATIONAHA.117.032790. [Epub ahead of print]
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2018
EBV-positive B-cell lymphoma manifestation of the liver in an infant with RAG1 severe combined immunodeficiency disease.
Maas C, Lüftinger R, Krois W, Matthes-Martin S, Bayer G, Boztug K, Metzelder M
Pediatr Blood Cancer. 2018 Jun 1:e27258. doi: 10.1002/pbc.27258. [Epub ahead of print]
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2018
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.
Hashimoto M, Girardi E, Eichner R, Superti-Furga G
ACS Chem Biol. 2018 Jun 6. doi: 10.1021/acschembio.8b00270. [Epub ahead of print]
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2018
An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, Sexl V, Bock C, Baccarini M
Cell Stem Cell. 2018 Jun 1;22(6):879-892.e6. doi: 10.1016/j.stem.2018.05.003. Epub 2018 May 24.
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2018
Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation, function and EBV immunity.
Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A, Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, Deenick EK, Uzel G, Tangye SG
J Allergy Clin Immunol. 2018 May 22. pii: S0091-6749(18)30702-4. doi: 10.1016/j.jaci.2018.04.030. [Epub ahead of print]
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2018
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space.
Klughammer J, Kiesel B, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, Nowosielski M, Augustin M, Mischkulnig M, Ströbel T, Alpar D, Ergüner B, Senekowitsch M, Moser P, Freyschlag CF, Kerschbaumer J, Thomé C, Grams AE, Stockhammer G, Kitzwoegerer M, Oberndorfer S, Marhold F, Weis S, Trenkler J, Buchroithner J, Pichler J, Haybaeck J, Krassnig S, Mahdy Ali K, von Campe G, Payer F, Sherif C, Preiser J, Hauser T, Winkler PA, Kleindienst W, Würtz F, Brandner-Kokalj T, Stultschnig M, Schweiger S, Dieckmann K, Preusser M, Langs G, Baumann B, Knosp E, Widhalm G, Marosi C, Hainfellner JA, Woehrer A, Bock C
Nat Med. 2018 Oct;24(10):1611-1624. doi: 10.1038/s41591-018-0156-x. Epub 2018 Aug 27.
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2018
Colocalization analyses of genomic elements: approaches, recommendations and challenges.
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Bioinformatics. 2018 Oct 11. doi: 10.1093/bioinformatics/bty835. [Epub ahead of print]
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2018
Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.
Javaheri T, Kazemi Z, Jan Pencik, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R
Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9.
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2018
Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.
Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, Bauer S, Erb MA, Parapatics K, Müller AC, Bennett KL, Ecker GF, Bradner JE, Winter GE
ACS Chem Biol. 2018 Mar 16;13(3):553-560. doi: 10.1021/acschembio.7b00969. Epub 2018 Jan 29.
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2018
Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.
Higareda-Almaraz JC, Karbiener M, Giroud M, Pauler FM, Gerhalter T, Herzig S, Scheideler M
BMC Genomics. 2018 Nov 3;19(1):794. doi: 10.1186/s12864-018-5173-0.
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2018
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G
Cell Death Differ. 2018 Sep 20. doi: 10.1038/s41418-018-0192-6. [Epub ahead of print]
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2018
Signatures of ecological processes in microbial community time series.
Faust K, Bauchinger F, Laroche B, de Buyl S, Lahti L, Washburne AD, Gonze D, Widder S
Microbiome. 2018 Jun 28;6(1):120. doi: 10.1186/s40168-018-0496-2.
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2018
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.
Cohen M, Giladi A, Gorki AD, Solodkin DG, Zada M, Hladik A, Miklosi A, Salame TM, Halpern KB, David E, Itzkovitz S, Harkany T, Knapp S, Amit I
Cell. 2018 Nov 1;175(4):1031-1044.e18. doi: 10.1016/j.cell.2018.09.009. Epub 2018 Oct 11.
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2018
In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens.
César-Razquin A, Girardi E, Yang M, Brehme M, Saez-Rodriguez J, Superti-Furga G
Front Pharmacol. 2018 Sep 7;9:1011. doi: 10.3389/fphar.2018.01011. eCollection 2018.
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2018
Lymphatic exosomes promote dendritic cell migration along guidance cues.
Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong YK, Bennett KL, Kain R, Detmar M, Sixt M, Jackson DG, Kerjaschki D
J Cell Biol. 2018 Jun 4;217(6):2205-2221. doi: 10.1083/jcb.201612051. Epub 2018 Apr 12.
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2018
LZTR1 is a regulator of RAS ubiquitination and signaling.
Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G
Science. 2018 Nov 15. pii: eaap8210. doi: 10.1126/science.aap8210. [Epub ahead of print]
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2018
An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, Sexl V, Bock C, Baccarini M
Cell Stem Cell. 2018 Jun 1;22(6):879-892.e6. doi: 10.1016/j.stem.2018.05.003. Epub 2018 May 24.
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2018
Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.
Barakat TS, Halbritter F, Zhang M, Rendeiro AF, Perenthaler E, Bock C, Chambers I
Cell Stem Cell. 2018 Aug 2;23(2):276-288.e8. doi: 10.1016/j.stem.2018.06.014. Epub 2018 Jul 19.
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2019
RnBeads 2.0: comprehensive analysis of DNA methylation data.
Müller F, Scherer M, Assenov Y, Lutsik P, Walter J, Lengauer T, Bock C
0: comprehensive analysis of DNA methylation data. Genome Biol. 2019Mar 14;20(1):55. doi: 10.1186/s13059-019-1664-9.
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2019
HACE1 deficiency leads to structural and functional neurodevelopmental defects.
Nagy V, Hollstein R, Pai TP, Herde MK, Buphamalai P, Moeseneder P, Lenartowicz E, Kavirayani A, Korenke GC, Kozieradzki I, Nitsch R, Cicvaric A, Monje Quiroga FJ, Deardorff MA, Bedoukian EC, Li Y, Yigit G, Menche J, Perçin EF, Wollnik B, Henneberger C, Kaiser FJ, Penninger JM
Neurol Genet. 2019 Apr29;5(3):e330. doi: 10.1212/NXG.0000000000000330. eCollection 2019 Jun. PubMedPMID: 31321300;
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2019
The Tubulin Detyrosination Cycle: Function andEnzymes.
Nieuwenhuis J, Brummelkamp TR
Trends Cell Biol. 2019 Jan;29(1):80-92. doi: 10.1016/j.tcb.2018.08.003. Epub 2018 Sep 10. Review.
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2019
Mapping the Human Kinome in Response to DNA Damage.
Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P, Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD, Loizou JI
Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
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2019
CD11b(+) cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption.
Patra V, Strobl J, Gruber-Wackernagel A, Vieyra-Garcia P, Stary G, Wolf P
Br J Dermatol. 2019 May 3. doi: 10.1111/bjd.18092. [Epub ahead ofprint]
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2019
Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms.
Pazmandi J, Kalinichenko A, Ardy RC, Boztug K
Immunol Rev. 2019 Jan;287(1):162-185. doi: 10.1111/imr.12726. Review.
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2017
Mutations in myeloproliferative neoplasms - their significance and clinical use.
Schischlik F, Kralovics R
Expert Rev Hematol. 2017 Nov;10(11):961-973. doi: 10.1080/17474086.2017.1380515. Epub 2017 Sep 25.
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2017
A slow-cycling subpopulation of melanoma cells with highly invasive properties.
Perego M, Maurer M, Wang JX, Shaffer S, Müller AC, Parapatics K, Li L, Hristova D, Shin S, Keeney F, Liu S, Xu X, Raj A, Jensen JK, Bennett KL, Wagner SN, Somasundaram R, Herlyn M
Oncogene. 2017 Sep 18. doi: 10.1038/onc.2017.341. [Epub ahead of print]
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2017
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance.
Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, Davies MA, Wargo J, Czerniecki BJ, Schuchter L, Herlyn D, Flaherty K, Herlyn M, Wagner SN
Nat Commun. 2017 Sep 19;8(1):607. doi: 10.1038/s41467-017-00452-4.
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2017
Multiple Presentations of LRBA Deficiency: a Single-Center Experience.
Kostel Bal S, Haskologlu S, Serwas NK, Islamoglu C, Aytekin C, Kendirli T, Kuloglu Z, Yavuz G, Dalgic B, Siklar Z, Kansu A, Ensari A, Boztug K, Dogu F, Ikinciogullari A
J Clin Immunol. 2017 Nov;37(8):790-800. doi: 10.1007/s10875-017-0446-y. Epub 2017 Sep 27.
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2017
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.
Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W
J Autoimmun. 2017 Sep 27. pii: S0896-8411(17)30595-4. doi: 10.1016/j.jaut.2017.09.008. [Epub ahead of print]
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2017
Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation.
Houben T, Oligschlaeger Y, Bitorina AV, Hendrikx T, Walenbergh SMA, Lenders MH, Gijbels MJJ, Verheyen F, Lütjohann D, Hofker MH, Binder CJ, Shiri-Sverdlov R
Sci Rep. 2017 Oct 2;7(1):12550. doi: 10.1038/s41598-017-13058-z.
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2017
First in human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.
Boidol B, Kornauth C, van der Kouwe E, Prutsch N, Kazianka L, Gültekin S, Hoermann G, Mayerhoefer ME, Hopfinger G, Hauswirth A, Panny M, Aretin MB, Hilgarth B, Sperr WR, Valent P, Simonitsch-Klupp I, Moriggl R, Merkel O, Kenner L, Jäger U, Kubicek S, Staber PB
Blood. 2017 Sep 27. pii: blood-2017-05-785683. doi: 10.1182/blood-2017-05-785683. [Epub ahead of print]
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2017
Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency.
Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW
Front Immunol. 2017 Oct 2;8:1250. doi: 10.3389/fimmu.2017.01250. eCollection 2017.
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2017
LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA
J Cell Biol. 2017 Oct 9. pii: jcb.201703061. doi: 10.1083/jcb.201703061. [Epub ahead of print]
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2017
Complement Activation in Peritoneal Dialysis-Induced Arteriolopathy.
Bartosova M, Schaefer B, Bermejo JL, Tarantino S, Lasitschka F, Macher-Goeppinger S, Sinn P, Warady BA, Zaloszyc A, Parapatics K, Májek P, Bennett KL, Oh J, Aufricht C, Schaefer F, Kratochwill K, Schmitt CP
J Am Soc Nephrol. 2017 Oct 18. pii: ASN.2017040436. doi: 10.1681/ASN.2017040436. [Epub ahead of print].
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2017
The fitness cost of mis-splicing is the main determinant of alternative splicing patterns.
Saudemont B, Popa A, Parmley JL, Rocher V, Blugeon C, Necsulea A, Meyer E, Duret L