Atherosclerosis & immunity
While acute inflammation is commonly beneficial, chronic or persistent inflammation can ultimately damage cells and tissues, and plays a causative role in several important human diseases, like atherosclerosis, which is the cause of heart attack and stroke.
Atherosclerosis is a chronic disease characterized by damage of vessel walls that is predominantly influenced by inflammation.
- Christoph Binder’s group studies the role of the immune system in atherosclerosis and the molecular mechanisms at play. They investigate the role of oxidation-specific epitopes, which are thought to drive the inflammatory response and promote disease progression, and the role of natural antibodies, which confer protection against atherosclerosis and may be harnessed as a new therapeutic strategy for treating this common disease.