Publications

YearPaper
2019 Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld OB, Altelaar M, Nieuwenhuis J, Celie PHN, Brummelkamp TR, Perrakis A. Crystal structure of thetubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nat Struct Mol Biol. 2019Jul;26(7):567-570. doi: 10.1038/s41594-019-0254-6. Epub 2019 Jul 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31270470
2019 Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T,Penninger JM, Pauler FM, Hudson QJ. The Airn lncRNA does not require any DNAelements within its locus to silence distant imprinted genes. PLoS Genet. 2019Jul 22;15(7):e1008268. doi: 10.1371/journal.pgen.1008268. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31329595
2019 Asp J, Skov V, Bellosillo B, Kristensen T, Lippert E, Dicker F, Schwarz J,Wojtaszewska M, Palmqvist L, Akiki S, Aggerholm A, Tolstrup Andersen M, GirodonF, Kjær L, Oppliger Leibundgut E, Pancrazzi A, Vorland M, Andrikovics H,Kralovics R, Cassinat B, Coucelo M, Eftimov A, Haslam K, Kusec R, Link-LenczowskaD, Lodé L, Matiakowska K, Naguib D, Navaglia F, Novotny GW, Percy MJ, SudarikovA, Hermouet S, Pallisgaard N. International external quality assurance of JAK2V617F quantification. Ann Hematol. 2019 May;98(5):1111-1118. doi:10.1007/s00277-018-3570-8. Epub 2018 Dec 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30535576
2019 Asslaber D, Wacht N, Leisch M, Qi Y, Maeding N, Hufnagl C, Jansko B, Zaborsky N, Villunger A, Hartmann TN, Greil R, Egle A. BIRC3 Expression Predicts CLLProgression and Defines Treatment Sensitivity via Enhanced NF-κB NuclearTranslocation. Clin Cancer Res. 2019 Mar 15;25(6):1901-1912. doi:10.1158/1078-0432.CCR-18-1548. Epub 2018 Nov 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30487125
2019 Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, AliA, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D,Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. CD8(+) T cells induce cachexia during chronic viral infection. Nat Immunol. 2019Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID:31110314;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6531346
2019 Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M,Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, BinderCJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-CellResponses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi:10.1161/ATVBAHA.118.312272. Epub 2019 May 16.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31092015
2019 Bier J, Rao G, Payne K, Brigden H, French E, Pelham SJ, Lau A, Lenthall H,Edwards ESJ, Smart JM, Cole TS, Choo S, Joshi AY, Abraham RS, O'Sullivan M, Boztug K, Meyts I, Gray PE, Berglund LJ, Hsu P, Wong M, Holland SM, NotarangeloLD, Uzel G, Ma CS, Brink R, Tangye SG, Deenick EK. Activating mutations in PIK3CDdisrupt the differentiation and function of human and murine CD4(+) T cells. JAllergy Clin Immunol. 2019 Jul;144(1):236-253. doi: 10.1016/j.jaci.2019.01.033.Epub 2019 Feb 6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30738173
2019 Bonelli M, Dalwigk K, Platzer A, Olmos Calvo I, Hayer S, Niederreiter B,Holinka J, Sevelda F, Pap T, Steiner G, Superti-Furga G, Smolen JS, Kiener HP,Karonitsch T. IRF1 is critical for the TNF-driven interferon response inrheumatoid fibroblast-like synoviocytes : JAKinibs suppress the interferonresponse in RA-FLSs. Exp Mol Med. 2019 Jul 8;51(7):75. doi:10.1038/s12276-019-0267-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31285419
2019 Brand M, Winter GE. Stick it to E3s. Nat Chem Biol. 2019 Jul;15(7):655-656.doi: 10.1038/s41589-019-0312-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31209352
2019 Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC,Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi:10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30595531
2019 Brand M, Winter GE. Locus-Specific Knock-In of a Degradable Tag for TargetValidation Studies. Methods Mol Biol. 2019;1953:105-119. doi:10.1007/978-1-4939-9145-7_7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30912018
2019 Brandstetter B, Dalwigk K, Platzer A, Niederreiter B, Kartnig F, Fischer A,Vladimer GI, Byrne RA, Sevelda F, Holinka J, Pap T, Steiner G, Superti-Furga G,Smolen JS, Kiener HP, Karonitsch T. FOXO3 is involved in the tumor necrosisfactor-driven inflammatory response in fibroblast-like synoviocytes. Lab Invest. 2019 May;99(5):648-658. doi: 10.1038/s41374-018-0184-7. Epub 2019 Jan 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30679758
2019 Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F,Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, NotarangeloLD. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combinedimmune deficiency in human subjects. J Allergy Clin Immunol. 2019Jun;143(6):2317-2321.e12. doi: 10.1016/j.jaci.2019.02.014. Epub 2019 Feb 26.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30822429
2019 Edwards ESJ, Bier J, Cole TS, Wong M, Hsu P, Berglund LJ, Boztug K, Lau A,Gostick E, Price DA, O'Sullivan M, Meyts I, Choo S, Gray P, Holland SM, DeenickEK, Uzel G, Tangye SG. Activating PIK3CD mutations impair human cytotoxiclymphocyte differentiation and function and EBV immunity. J Allergy Clin Immunol.2019 Jan;143(1):276-291.e6. doi: 10.1016/j.jaci.2018.04.030. Epub 2018 May 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29800648
2019 Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, SchuetzC, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C,Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG,Lycopoulou L, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, DbaiboG, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM,Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C,Wolska-Kuśnierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, ChandrakasanS, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O,Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B,Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR,Notarangelo LD, Walter JE. Outcomes and Treatment Strategies for Autoimmunity andHyperinflammation in Patients with RAG Deficiency. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1970-1985.e4. doi: 10.1016/j.jaip.2019.02.038. Epub 2019 Mar 12.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30877075
2019 Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW,Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K,Superti-Furga G. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30237509
2019 Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M,Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J,Bergthaler A, Steiner G, Blüml S. MicroRNA-155 Controls T Helper Cell Activation During Viral Infection. Front Immunol. 2019 Jun 13;10:1367. doi:10.3389/fimmu.2019.01367. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31275315
2019 Gruber M, Bozic I, Leshchiner I, Livitz D, Stevenson K, Rassenti L, RosebrockD, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, BrownJR, Neuberg D, Kipps TJ, Nowak MA, Getz G, Wu CJ. Growth dynamics in naturallyprogressing chronic lymphocytic leukaemia. Nature. 2019 Jun;570(7762):474-479.doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31142838
2019 Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GA. Arepetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52. Sci Rep. 2019 May 27;9(1):7901. doi:10.1038/s41598-019-44359-0.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133683
2019 Hamdane N, Jühling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, BandieraS, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I,Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoël M,Piardi T, Sommacale D, Imamura M, Uchida T, Ohdan H, Aikata H, Chayama K,Boldanova T, Pessaux P, Fuchs BC, Hoshida Y, Zeisel MB, Duong FHT, Baumert TF.HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist AfterSustained Virologic Response. Gastroenterology. 2019 Jun;156(8):2313-2329.e7.doi: 10.1053/j.gastro.2019.02.038. Epub 2019 Mar 2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30836093
2019 Heijink AM, Talens F, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM. BRCA2 deficiency instigates cGAS-mediated inflammatory signaling andconfers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. NatCommun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. PubMed PMID:30626869;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6327059
2019 Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK. Colocalization analysesof genomic elements: approaches, recommendations and challenges. Bioinformatics. 2019 May 1;35(9):1615-1624. doi: 10.1093/bioinformatics/bty835. PubMed PMID:30307532;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6499241
2019 Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C,Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC. Immunometabolismand atherosclerosis: perspectives and clinical significance: a position paperfrom the Working Group on Atherosclerosis and Vascular Biology of the EuropeanSociety of Cardiology. Cardiovasc Res. 2019 Jul 1;115(9):1385-1392. doi:10.1093/cvr/cvz166.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31228191
2019 Kocacik Uygun DF, Uygun V, Daloğlu H, Öztürkmen S, Karasu G, Reisli İ, Sayar E, Yüksekkaya HA, Glocker EO, Boztuğ K, Yeşilipek A. Hematopoietic Stem CellTransplantation From Unrelated Donors in 2 Cases of Interleukin-10 ReceptorDeficiency: Is Surgery Not a Requirement? J Pediatr Hematol Oncol. 2019Jan;41(1):64-66. doi: 10.1097/MPH.0000000000001165.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29683948
2019 Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P,Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H,de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. TheERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease. Cancer Cell. 2019Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30645971
2019 Lee NJ, Clarke IM, Zengin A, Enriquez RF, Nagy V, Penninger JM, Baldock PA,Herzog H. RANK deletion in neuropeptide Y neurones attenuates oestrogendeficiency-related bone loss. J Neuroendocrinol. 2019 Feb;31(2):e12687. doi:10.1111/jne.12687. Epub 2019 Feb 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30633834
2019 Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T,Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O,Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, ProchazkovaJ, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A,Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L,Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.Haematologica. 2019 May 23. pii: haematol.2019.216986. doi:10.3324/haematol.2019.216986. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31123029
2019 Mayor-Ruiz C, Winter GE. Identification and characterization of cancervulnerabilities via targeted protein degradation. Drug Discov Today Technol. 2019Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31200863.
2019 McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L,Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M,Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb13.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30760925
2019 Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA,Brummelkamp TR, Schumacher TN. SLFN11 can sensitize tumor cells towardsIFN-γ-mediated T cell killing. PLoS One. 2019 Feb 12;14(2):e0212053. doi:10.1371/journal.pone.0212053. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30753225
2019 Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M,Ottmann OG, Hantschel O. The phosphatase UBASH3B/Sts-1 is a negative regulator ofBcr-Abl kinase activity and leukemogenesis. Leukemia. 2019 Apr 8. doi:10.1038/s41375-019-0468-y. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30962580
2019 Moik F, Riedl JM, Winder T, Terbuch A, Rossmann CH, Szkandera J, Bauernhofer T, Kasparek AK, Schaberl-Moser R, Reicher A, Prinz F, Pichler M, Stöger H, Stotz M, Gerger A, Posch F. Benefit of second-line systemic chemotherapy for advancedbiliary tract cancer: A propensity score analysis. Sci Rep. 2019 Apr 3;9(1):5548.doi: 10.1038/s41598-019-42069-1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30944390
2019 Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G,Girardi E, Superti-Furga G. The transporters SLC35A1 and SLC30A1 play oppositeroles in cell survival upon VSV virus infection. Sci Rep. 2019 Jul 18;9(1):10471.doi: 10.1038/s41598-019-46952-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31320712
2019 Müller F, Scherer M, Assenov Y, Lutsik P, Walter J, Lengauer T, Bock C.RnBeads 2.0: comprehensive analysis of DNA methylation data. Genome Biol. 2019Mar 14;20(1):55. doi: 10.1186/s13059-019-1664-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30871603
2019 Nagy V, Hollstein R, Pai TP, Herde MK, Buphamalai P, Moeseneder P,Lenartowicz E, Kavirayani A, Korenke GC, Kozieradzki I, Nitsch R, Cicvaric A,Monje Quiroga FJ, Deardorff MA, Bedoukian EC, Li Y, Yigit G, Menche J, Perçin EF,Wollnik B, Henneberger C, Kaiser FJ, Penninger JM. HACE1 deficiency leads tostructural and functional neurodevelopmental defects. Neurol Genet. 2019 Apr29;5(3):e330. doi: 10.1212/NXG.0000000000000330. eCollection 2019 Jun. PubMedPMID: 31321300;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6561753
2019 Nieuwenhuis J, Brummelkamp TR. The Tubulin Detyrosination Cycle: Function andEnzymes. Trends Cell Biol. 2019 Jan;29(1):80-92. doi: 10.1016/j.tcb.2018.08.003. Epub 2018 Sep 10. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30213517
2019 Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P,Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD,Loizou JI. Mapping the Human Kinome in Response to DNA Damage. Cell Rep. 2019 Jan15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30650350
2019 Patra V, Strobl J, Gruber-Wackernagel A, Vieyra-Garcia P, Stary G, Wolf P.CD11b(+) cells markedly express the itch cytokine interleukin-31 in polymorphiclight eruption. Br J Dermatol. 2019 May 3. doi: 10.1111/bjd.18092. [Epub ahead ofprint]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31049931
2019 Pazmandi J, Kalinichenko A, Ardy RC, Boztug K. Early-onset inflammatory boweldisease as a model disease to identify key regulators of immune homeostasismechanisms. Immunol Rev. 2019 Jan;287(1):162-185. doi: 10.1111/imr.12726. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30565237
2019 Pecquet C, Chachoua I, Roy A, Balligand T, Vertenoeil G, Leroy E, Albu RI,Defour JP, Nivarthi H, Hug E, Xu E, Ould-Amer Y, Mouton C, Colau D, Vertommen D, Shwe MM, Marty C, Plo I, Vainchenker W, Kralovics R, Constantinescu SN.Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defectivepathogenic TpoR mutants. Blood. 2019 Jun 20;133(25):2669-2681. doi:10.1182/blood-2018-09-874578. Epub 2019 Mar 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30902807
2019 Porsch F, Binder CJ. Impact of B-Cell-Targeted Therapies on CardiovascularDisease. Arterioscler Thromb Vasc Biol. 2019 Jul 18:ATVBAHA119311996. doi:10.1161/ATVBAHA.119.311996. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31315439
2019 Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M,Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N,Boilard E, Binder CJ. Mitochondria Are a Subset of Extracellular VesiclesReleased by Activated Monocytes and Induce Type I IFN and TNF Responses inEndothelial Cells. Circ Res. 2019 Jun 21;125(1):43-52. doi:10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31219742
2019 Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M,Reichardt HM, Villunger A, Tischner D, Wiegers GJ. GlucocorticoidReceptor-Deficient Foxp3(+) Regulatory T Cells Fail to Control ExperimentalInflammatory Bowel Disease. Front Immunol. 2019 Mar 18;10:472. doi:10.3389/fimmu.2019.00472. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30936873
2019 Sage AP, Tsiantoulas D, Binder CJ, Mallat Z. The role of B cells inatherosclerosis. Nat Rev Cardiol. 2019 Mar;16(3):180-196. doi:10.1038/s41569-018-0106-9. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30410107
2019 Scalise M, Galluccio M, Pochini L, Cosco J, Trotta M, Rebsamen M,Superti-Furga G, Indiveri C. Insights into the transport side of the humanSLC38A9 transceptor. Biochim Biophys Acta Biomembr. 2019 Jul 8;1861(9):1558-1567.doi: 10.1016/j.bbamem.2019.07.006. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31295473
2019 Schiefer AI, Salzer E, Füreder A, Szepfalusi Z, Müller-Sacherer T, Huber WD, Michel-Behnke I, Lawitschka A, Pichler H, Mann G, Hutter C, Simonitsch-Klupp I,Attarbaschi A. PD-L1 and PD1 expression in post-transplantationlymphoproliferative disease (PTLD) of childhood and adolescence: An inter- andintra-individual descriptive study covering the whole spectrum of PTLDcategories. Cancer Med. 2019 Jul 3. doi: 10.1002/cam4.2394. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31269329
2019 Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E,Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D,Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A,Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of thetranscriptome offers putative targets for immunotherapy of myeloproliferativeneoplasms. Blood. 2019 Jul 11;134(2):199-210. doi: 10.1182/blood.2019000519. Epub2019 May 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31064751
2019 Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C,Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K,Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, HoermannG, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C. Combinedchemosensitivity and chromatin profiling prioritizes drug combinations in CLL.Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692684
2019 Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A,Rajewsky K, Labi V. TET enzymes control antibody production and shape themutational landscape in germinal centre B cells. FEBS J. 2019 May 23. doi:10.1111/febs.14934. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31120187
2019 Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N,Villunger A, Labi V. CHK1 dosage in germinal center B cells controls humoralimmunity. Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5. [Epubahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30894677
2019 Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A. Checkpointkinase 1 is essential for fetal and adult hematopoiesis. EMBO Rep. 2019 Jun 17.pii: e47026. doi: 10.15252/embr.201847026. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31208967
2019 Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G,Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P,Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL,Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, MechtlerK, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J,Kubicek S. MTHFD1 interaction with BRD4 links folate metabolism totranscriptional regulation. Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133746
2019 Semmler G, Simbrunner B, Scheiner B, Schwabl P, Paternostro R, Bucsics T,Stättermayer AF, Bauer D, Pinter M, Ferenci P, Trauner M, Mandorfer M, Reiberger T. Impact of farnesoid X receptor single nucleotide polymorphisms on hepaticdecompensation and mortality in cirrhotic patients with portal hypertension. JGastroenterol Hepatol. 2019 May 6. doi: 10.1111/jgh.14700. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31062417
2019 Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Yüce Petronczki Ö, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Loizou JI, Kain R,Bidmon-Fliegenschnee B, Schickel JN, Glauzy S, Huemer J, Garncarz W, Salzer E,Pierides I, Bilic I, Thiel J, Priftakis P, Banerjee PP, Förster-Waldl E, MedgyesiD, Huber WD, Orange JS, Meffre E, Sansom DM, Bryceson YT, Altman A, Boztug K.Human DEF6 deficiency underlies an immunodeficiency syndrome with systemicautoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019 Jul 15;10(1):3106.doi: 10.1038/s41467-019-10812-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31308374
2019 Shabani M, Aleyasin S, Kashef S, Zoghi S, Deswarte C, Casanova JL, BustamanteJ, Rezaei N. A Novel Recessive Mutation of Interferon-γ Receptor 1 in a Patientwith Mycobacterium tuberculosis in Bone Marrow Aspirate. J Clin Immunol. 2019Feb;39(2):127-130. doi: 10.1007/s10875-019-00595-7. Epub 2019 Feb 5.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30719685
2019 Shahin T, Aschenbrenner D, Cagdas D, Bal SK, Conde CD, Garncarz W, MedgyesiD, Schwerd T, Karaatmaca B, Cetinkaya PG, Esenboga S, Twigg SRF, Cant A, WilkieAOM, Tezcan I, Uhlig HH, Boztug K. Selective loss of function variants in IL6STcause Hyper-IgE syndrome with distinct impairments of T-cell phenotype andfunction. Haematologica. 2019 Mar;104(3):609-621. doi:10.3324/haematol.2018.194233. Epub 2018 Oct 11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30309848
2019 Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B. NK Cells Require Cell-Extrinsic and-Intrinsic TYK2 for Full Functionality in Tumor Surveillance and AntibacterialImmunity. J Immunol. 2019 Mar 15;202(6):1724-1734. doi: 10.4049/jimmunol.1701649.Epub 2019 Feb 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718299
2019 Singh DD, Hawkins RD, Lahesmaa R, Tripathi SK. CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediateddiseases. Semin Cell Dev Biol. 2019 Jun 19. pii: S1084-9521(18)30111-3. doi:10.1016/j.semcdb.2019.05.007. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31112800
2019 Skucha A, Ebner J, Grebien F. Roles of SETD2 in Leukemia-Transcription,DNA-Damage, and Beyond. Int J Mol Sci. 2019 Feb 27;20(5). pii: E1029. doi:10.3390/ijms20051029. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30818762
2019 Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L,Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML,Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L,Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I. Spatiotemporal structure of cell fate decisions in murine neuralcrest. Science. 2019 Jun 7;364(6444). pii: eaas9536. doi:10.1126/science.aas9536.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31171666
2019 Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M,Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M,Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD,Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD,Thaventhiran JED. Loss of the interleukin-6 receptor causes immunodeficiency,atopy, and abnormal inflammatory responses. J Exp Med. 2019 Jun 24. pii:jem.20190344. doi: 10.1084/jem.20190344. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31235509
2019 Staber PB, Herling M, Bellido M, Jacobsen ED, Davids MS, Kadia TM, Shustov A,Tournilhac O, Bachy E, Zaja F, Porkka K, Hoermann G, Simonitsch I, Haferlach C,Kubicek S, Mayerhoefer M, Hopfinger G, Jaeger U, Dearden C. Consensus criteriafor diagnosis, staging, and treatment response assessment of T-cellprolymphocytic leukemia (T-PLL). Blood. 2019 Jul 10. pii: blood.2019000402. doi: 10.1182/blood.2019000402. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31292114
2019 Unterhauser K, Pöltl L, Schneditz G, Kienesberger S, Glabonjat RA, Kitsera M,Pletz J, Josa-Prado F, Dornisch E, Lembacher-Fadum C, Roier S, Gorkiewicz G,Lucena D, Barasoain I, Kroutil W, Wiedner M, Loizou JI, Breinbauer R, Díaz JF,Schild S, Högenauer C, Zechner EL. Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizingactivities. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3774-3783. doi:10.1073/pnas.1819154116. Epub 2019 Feb 11.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30808763
2019 Uras IZ, Maurer B, Nivarthi H, Jodl P, Kollmann K, Prchal-Murphy M, MilosevicFeenstra JD, Zojer M, Lagger S, Grausenburger R, Grabner B, Holly R, KavirayaniA, Bock C, Gisslinger H, Valent P, Kralovics R, Sexl V. CDK6 coordinates JAK2(V617F) mutant MPN via NF-κB and apoptotic networks. Blood. 2019 Apr11;133(15):1677-1690. doi: 10.1182/blood-2018-08-872648. Epub 2019 Jan 11. PubMedPMID: 30635286;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6543514
2019 Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA,Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lubbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstocker M,Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA,Malcovati L, Bennett JM. Proposed diagnostic criteria for classical CMML, CMMLvariants and pre-CMML conditions. Haematologica. 2019 May 2. pii:haematol.2019.222059. doi: 10.3324/haematol.2019.222059. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31048353
2019 van Mierlo G, Dirks RAM, De Clerck L, Brinkman AB, Huth M, Kloet SL, Saksouk N, Kroeze LI, Willems S, Farlik M, Bock C, Jansen JH, Deforce D, Vermeulen M,Déjardin J, Dhaenens M, Marks H. Integrative Proteomic Profiling RevealsPRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. CellStem Cell. 2019 Jan 3;24(1):123-137.e8. doi: 10.1016/j.stem.2018.10.017. Epub2018 Nov 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30472157
2019 Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A,Merkel A, Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH, Clarke L, Heath S, van der Reijden BA, Flicek P, Yaspo ML, Gut I, Bock C, Schuringa JJ, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA.Chromatin-Based Classification of Genetically Heterogeneous AMLs into TwoDistinct Subtypes with Diverse Stemness Phenotypes. Cell Rep. 2019 Jan22;26(4):1059-1069.e6. doi: 10.1016/j.celrep.2018.12.098.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30673601
2019 Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S,Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T,Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, HabenichtAJR. ApoE attenuates unresolvable inflammation by complex formation withactivated C1q. Nat Med. 2019 Mar;25(3):496-506. doi: 10.1038/s41591-018-0336-8.Epub 2019 Jan 28. Erratum in: Nat Med. 2019 Feb 4;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692699
2019 Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31442425
2019 Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Májek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Müller AC, Bock C, Kubicek S. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019 Sep;51(9):1399-1410. doi: 10.1038/s41588-019-0477-9. Epub 2019 Aug 19.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31427792
2019 Chen Y, Coussanes G, Souris C, Aillard P, Kaldre D, Runggatscher K, Kubicek S, Di Mauro G, Maryasin B, Maulide N. A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants. J Am Chem Soc. 2019 Sep 4;141(35):13772-13777. doi: 10.1021/jacs.9b07185. Epub 2019 Aug 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31436963
2019 Conde CD, Petronczki ÖY, Baris S, Willmann KL, Girardi E, Salzer E, Weitzer S, Ardy RC, Krolo A, Ijspeert H, Kiykim A, Karakoc-Aydiner E, Förster-Waldl E, Kager L, Pickl WF, Superti-Furga G, Martínez J, Loizou JI, Ozen A, van der Burg M, Boztug K. Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. J Clin Invest. 2019 Aug 26. pii: 128903. doi: 10.1172/JCI128903. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31449058
2019 Kiss MG, Ozsvár-Kozma M, Porsch F, Göderle L, Papac-Miličević N, Bartolini-Gritti B, Tsiantoulas D, Pickering MC, Binder CJ. Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production. Front Immunol. 2019 Jul 11;10:1607. doi: 10.3389/fimmu.2019.01607. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31354740
2019 Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A. Checkpoint kinase 1 is essential for fetal and adult hematopoiesis. EMBO Rep. 2019 Aug;20(8):e47026. doi: 10.15252/embr.201847026. Epub 2019 Jun 17.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31379128
2019 Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld OB, Altelaar M, Nieuwenhuis J, Celie PHN, Brummelkamp TR, Perrakis A. Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nat Struct Mol Biol. 2019 Jul;26(7):567-570. doi: 10.1038/s41594-019-0254-6. Epub 2019 Jul 1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31270470
2019 Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K. CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis. Blood. 2019 Sep 9. pii: blood.2019000644. doi: 10.1182/blood.2019000644. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31501153