2025
Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5
Wen-An Wang,
Evandro Ferrada,
Christoph Klimek,
Tanja Osthushenrich,
Aidan MacNamara,
Tabea Wiedmer,
Giulio Superti-Furga.
Sci Adv. 2025 Jun 27;11(26):eadx3011. doi: 10.1126/sciadv.adx3011. Epub 2025 Jun 27.
2025
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
Ramona Rica,
Monika Waldherr,
Emi Miyakoda,
Ana Patricia Kutschat,
Marlene Schülein,
Jing Zhang,
Ricardo Alfredo Orbegozo-Medina,
Lisa Sandner,
Valentina Stolz,
Darina Waltenberger,
Thomas Krausgruber,
Christoph Bock,
Nicole Boucheron,
Davide Seruggia,
Wilfried Ellmeier,
Shinya Sakaguchi.
J Exp Med. 2025 Aug 4;222(8):e20240829. doi: 10.1084/jem.20240829. Epub 2025 Jun 4.
2025
Probing condensate microenvironments with a micropeptide killswitch
Yaotian Zhang,
Ida Stöppelkamp,
Pablo Fernandez-Pernas,
Melanie Allram,
Matthew Charman,
Alexandre P Magalhaes,
Melanie Piedavent-Salomon,
Gregor Sommer,
Yu-Chieh Sung,
Katrina Meyer,
Nicholas Grams,
Edwin Halko,
Shivali Dongre,
David Meierhofer,
Michal Malszycki,
Ibrahim A Ilik,
Tugce Aktas,
Matthew L Kraushar,
Nadine Vastenhouw,
Matthew D Weitzman,
Florian Grebien,
Henri Niskanen,
Denes Hnisz.
Nature. 2025 Jun 4. doi: 10.1038/s41586-025-09141-5. Online ahead of print.
2025
Mast cells activated in vitro can modulate macrophage polarization and antibacterial responses
Dorothea B Holter,
Sophie Zahalka,
Jessica Brösamlen,
Mariem Radhouani,
Martin L Watzenboeck,
Tyler J Artner,
Asma Farhat,
Riem Gawish,
Karin Lakovits,
Anastasiya Hladik,
Federica Quattrone,
Wolfgang Weninger,
Thomas Krausgruber,
Shane J F Cronin,
Shweta Tikoo,
Rohit Jain,
Sylvia Knapp,
Nikolaus Fortelny,
Philipp Starkl.
J Allergy Clin Immunol. 2025 May 26:S0091-6749(25)00575-5. doi: 10.1016/j.jaci.2025.02.040. Online ahead of print.
2025
The human proteome with direct physical access to DNA
Jakob Trendel,
Simon Trendel,
Shuyao Sha,
Franziska Greulich,
Sandra Goll,
Susanne I Wudy,
Karin Kleigrewe,
Stefan Kubicek,
N Henriette Uhlenhaut,
Bernhard Kuster.
Cell. 2025 May 14:S0092-8674(25)00507-0. doi: 10.1016/j.cell.2025.04.037. Online ahead of print.
2025
Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross-Over Study in Healthy Volunteers
Evette B M Hillman,
Maximilian Baumgartner,
Danielle Carson,
Gregory C A Amos,
Imad Wazir,
Haider A Khan,
Malik A Khan,
Sjoerd Rijpkema,
Julian R F Walters,
Elizabeth M H Wellington,
Ramesh Arasaradnam,
Stephen J Lewis.
Neurogastroenterol Motil. 2025 May 20:e70075. doi: 10.1111/nmo.70075. Online ahead of print.
2025
Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1
Ashutosh Gulati,
Do-Hwan Ahn,
Albert Suades,
Yurie Hult,
Gernot Wolf,
So Iwata,
Giulio Superti-Furga,
Norimichi Nomura,
David Drew.
Nature. 2025 May 21. doi: 10.1038/s41586-025-09069-w. Online ahead of print.
2025
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Selina Troester,
Thomas Eder,
Nadja Wukowits,
Martin Piontek,
Pablo Fernández-Pernas,
Johannes Schmoellerl,
Ben Haladik,
Gabriele Manhart,
Melanie Allram,
Margarita Maurer-Granofszky,
Nastassja Scheidegger,
Karin Nebral,
Giulio Superti-Furga,
Roland Meisel,
Beat Bornhauser,
Peter Valent,
Michael N Dworzak,
Johannes Zuber,
Kaan Boztug,
Florian Grebien.
Nat Commun. 2025 May 19;16(1):4656. doi: 10.1038/s41467-025-59930-9.
2025
Data- and knowledge-derived functional landscape of human solute carriers
Ulrich Goldmann,
Tabea Wiedmer,
Andrea Garofoli,
Vitaly Sedlyarov,
Manuel Bichler,
Ben Haladik,
Gernot Wolf,
Eirini Christodoulaki,
Alvaro Ingles-Prieto,
Evandro Ferrada,
Fabian Frommelt,
Shao Thing Teoh,
Philipp Leippe,
Gabriel Onea,
Martin Pfeifer,
Mariah Kohlbrenner,
Lena Chang,
Paul Selzer,
Jürgen Reinhardt,
Daniela Digles,
Gerhard F Ecker,
Tanja Osthushenrich,
Aidan MacNamara,
Anders Malarstig,
David Hepworth,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):599-631. doi: 10.1038/s44320-025-00108-2. Epub 2025 May 12.
2025
Metabolic mapping of the human solute carrier superfamily
Tabea Wiedmer,
Shao Thing Teoh,
Eirini Christodoulaki,
Gernot Wolf,
Chengzhe Tian,
Vitaly Sedlyarov,
Abigail Jarret,
Philipp Leippe,
Fabian Frommelt,
Alvaro Ingles-Prieto,
Sabrina Lindinger,
Barbara M G Barbosa,
Svenja Onstein,
Christoph Klimek,
Julio Garcia,
Iciar Serrano,
Daniela Reil,
Diana Santacruz,
Mary Piotrowski,
Stephen Noell,
Christoph Bueschl,
Huanyu Li,
Gamma Chi,
Stefan Mereiter,
Tiago Oliveira,
Josef M Penninger,
David B Sauer,
Claire M Steppan,
Coralie Viollet,
Kristaps Klavins,
J Thomas Hannich,
Ulrich Goldmann,
Giulio Superti-Furga.
Mol Syst Biol. 2025 Jun;21(6):560-598. doi: 10.1038/s44320-025-00106-4. Epub 2025 May 12.
