Publications

Year

Paper

2023

Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome
Benedikt Simbrunner, Ida Falk Villesen, Bernhard Scheiner, Rafael Paternostro, Philipp Schwabl, Albert Friedrich Stättermayer, Rodrig Marculescu, Matthias Pinter, Peter Quehenberger, Michael Trauner, Morten Karsdal, Ton Lisman, Thomas Reiberger, Diana Julie Leeming, Mattias Mandorfer.
Hepatol Int. 2023 Dec;17(6):1532-1544. doi: 10.1007/s12072-023-10577-y. Epub 2023 Aug 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37605068/

2023

GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2^-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling
Claudia D Fuchs, Thierry Claudel, Veronika Mlitz, Alessandra Riva, Moritz Menz, Ksenia Brusilovskaya, Felix Haller, Maximilian Baumgartner, Philipp Königshofer, Lukas W Unger, Wilhelm Sjöland, Hubert Scharnagl, Tatjana Stojakovic, Georg Busslinger, Thomas Reiberger, Hanns-Ulrich Marschall, Michael Trauner.
Cell Mol Gastroenterol Hepatol. 2023;16(5):847-856. doi: 10.1016/j.jcmgh.2023.08.003. Epub 2023 Aug 10.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37572734/

2023

Dysregulated biomarkers of innate and adaptive immunity predict infections and disease progression in cirrhosis
Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, David J M Bauer, Bernhard Scheiner, Benedikt Silvester Hofer, Albert Friedrich Stättermayer, Rodrig Marculescu, Michael Trauner, Mattias Mandorfer, Thomas Reiberger.
JHEP Rep. 2023 Feb 24;5(5):100712. doi: 10.1016/j.jhepr.2023.100712. eCollection 2023 May.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37035457/

2023

Disturbances in sodium and chloride homeostasis predict outcome in stable and critically ill patients with cirrhosis
Georg Semmler, Bernhard Scheiner, Lorenz Balcar, Rafael Paternostro, Benedikt Simbrunner, Matthias Pinter, Michael Trauner, Marta Bofill Roig, Elias Laurin Meyer, Benedikt Silvester Hofer, Mattias Mandorfer, David James Pinato, Christian Zauner, Thomas Reiberger, Georg-Christian Funk.
Aliment Pharmacol Ther. 2023 Jul;58(1):71-79. doi: 10.1111/apt.17507. Epub 2023 Apr 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37016513/

2023

Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response
Benedikt Simbrunner, Esther Caparrós, Teresa Neuwirth, Philipp Schwabl, Philipp Königshofer, David Bauer, Rodrig Marculescu, Michael Trauner, Bernhard Scheiner, Georg Stary, Mattias Mandorfer, Thomas Reiberger, Rubén Francés.
Hepatol Int. 2023 Aug;17(4):1045-1056. doi: 10.1007/s12072-023-10496-y. Epub 2023 Mar 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36881247/

2022

Imaging features facilitate diagnosis of porto-sinusoidal vascular disorder
Katharina Lampichler, Georg Semmler, Katharina Wöran, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, David Josef Maria Bauer, Lorenz Balcar, Lukas Burghart, Michael Trauner, Dietmar Tamandl, Ahmed Ba-Ssalamah, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner, Martina Scharitzer.
Eur Radiol. 2023 Feb;33(2):1422-1432. doi: 10.1007/s00330-022-09132-4. Epub 2022 Sep 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36166087/

2022

Imaging features facilitate diagnosis of porto-sinusoidal vascular disorder
Katharina Lampichler, Georg Semmler, Katharina Wöran, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, David Josef Maria Bauer, Lorenz Balcar, Lukas Burghart, Michael Trauner, Dietmar Tamandl, Ahmed Ba-Ssalamah, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner, Martina Scharitzer.
Eur Radiol. 2022 Sep 27. doi: 10.1007/s00330-022-09132-4. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36166087/

2022

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis
Jiří Reiniš, Oleksandr Petrenko, Benedikt Simbrunner, Benedikt S Hofer, Filippo Schepis, Marco Scoppettuolo, Dario Saltini, Federica Indulti, Tomas Guasconi, Agustin Albillos, Luis Téllez, Càndid Villanueva, Anna Brujats, Juan Carlos Garcia-Pagan, Valeria Perez-Campuzano, Virginia Hernández-Gea, Pierre-Emmanuel Rautou, Lucile Moga, Thomas Vanwolleghem, Wilhelmus J Kwanten, Sven Francque, Jonel Trebicka, Wenyi Gu, Philip G Ferstl, Lise Lotte Gluud, Flemming Bendtsen, Søren Møller, Stefan Kubicek, Mattias Mandorfer, Thomas Reiberger.
J Hepatol. 2023 Feb;78(2):390-400. doi: 10.1016/j.jhep.2022.09.012. Epub 2022 Sep 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36152767/

2022

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis
Jiří Reiniš, Oleksandr Petrenko, Benedikt Simbrunner, Benedikt S Hofer, Filippo Schepis, Marco Scoppettuolo, Dario Saltini, Federica Indulti, Tomas Guasconi, Agustin Albillos, Luis Téllez, Càndid Villanueva, Anna Brujats, Juan Carlos Garcia-Pagan, Valeria Perez-Campuzano, Virginia Hernández-Gea, Pierre-Emmanuel Rautou, Lucile Moga, Thomas Vanwolleghem, Wilhelmus J Kwanten, Sven Francque, Jonel Trebicka, Wenyi Gu, Philip G Ferstl, Lise Lotte Gluud, Flemming Bendtsen, Søren Møller, Stefan Kubicek, Mattias Mandorfer, Thomas Reiberger.
J Hepatol. 2022 Sep 22:S0168-8278(22)03119-1. doi: 10.1016/j.jhep.2022.09.012. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36152767/

2022

Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease
Benedikt Simbrunner, Ida Falk Villesen, Philipp Königshofer, Bernhard Scheiner, David Bauer, Rafael Paternostro, Philipp Schwabl, Gerald Timelthaler, Dariga Ramazanova, Katharina Wöran, Judith Stift, Ernst Eigenbauer, Albert Friedrich Stättermayer, Rodrig Marculescu, Matthias Pinter, Søren Møller, Michael Trauner, Morten Karsdal, Diana Julie Leeming, Thomas Reiberger, Mattias Mandorfer.
Liver Int. 2022 Nov;42(11):2501-2512. doi: 10.1111/liv.15365. Epub 2022 Aug 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35822301/

2022

Angiopoietin 2 levels decrease after HCV-cure and reflect the evolution of portal hypertension
David Bauer, Karin Kozbial, Philipp Schwabl, David Chromy, Benedikt Simbrunner, Albert F Stättermayer, Matthias Pinter, Petra Steindl-Munda, Michael Trauner, Peter Ferenci, Thomas Reiberger, Mattias Mandorfer.
Dig Liver Dis. 2022 Sep;54(9):1222-1229. doi: 10.1016/j.dld.2022.02.013. Epub 2022 Apr 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35382974/

2022

Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension
Philipp Schwabl, Berit Anna Seeland, Florian Riedl, Tim Lukas Schubert, Philipp Königshofer, Ksenia Brusilovskaya, Oleksandr Petrenko, Benedikt Hofer, Ana-Iris Schiefer, Michael Trauner, Markus Peck-Radosavljevic, Thomas Reiberger.
Adv Med Sci. 2022 Mar;67(1):154-162. doi: 10.1016/j.advms.2022.02.005. Epub 2022 Mar 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35272246/

2022

Year

Paper

2021

Balcar L, Semmler G, Pomej K, Simbrunner B, Bauer D, Hartl L, Jachs M, Paternostro R, Bucsics T, Pinter M, Trauner M, Mandorfer M, Reiberger T, Scheiner B. Patterns of acute decompensation in hospitalized patients with cirrhosis and course of acute-on-chronic liver failure. United European Gastroenterol J. 2021 May;9(4):427-437. doi: 10.1002/ueg2.12089.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34050619/

2021

Königshofer P, Brusilovskaya K, Petrenko O, Hofer BS, Schwabl P, Trauner M, Reiberger T. Nuclear receptors in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166235. doi: 10.1016/j.bbadis.2021.166235. Epub 2021 Jul 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34339839/

2021

Costa D, Simbrunner B, Jachs M, Hartl L, Bauer D, Paternostro R, Schwabl P, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T. Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality. J Hepatol. 2021 Apr;74(4):819-828. doi: 10.1016/j.jhep.2020.10.004. Epub 2020 Oct 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33075344/

2021

Schwabl P, Hambruch E, Budas GR, Supper P, Burnet M, Liles JT, Birkel M, Brusilovskaya K, Königshofer P, Peck-Radosavljevic M, Watkins WJ, Trauner M, Breckenridge DG, Kremoser C, Reiberger T. The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model. Biomedicines. 2021 Jan 9;9(1):60. doi: 10.3390/biomedicines9010060.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33435509/

2021

Costa D, Simbrunner B, Reiberger T. Reply to: "Prognostic role of systemic inflammatory biomarkers in advanced chronic liver disease". J Hepatol. 2021 Apr;74(4):1000-1001. doi: 10.1016/j.jhep.2021.01.026. Epub 2021 Jan 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33497763/

2021

Simbrunner B, Costa D, Reiberger T. Reply to: "Presepsin as a biomarker of inflammation and prognosis in decompensated liver disease". J Hepatol. 2021 Apr 20:S0168-8278(21)00233-6. doi: 10.1016/j.jhep.2021.03.027. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33852949/

2020

Simbrunner B, Marculescu R, Scheiner B, Schwabl P, Bucsics T, Stadlmann A, Bauer DJM, Paternostro R, Eigenbauer E, Pinter M, Stättermayer AF, Trauner M, Mandorfer M, Reiberger T. Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease. Liver Int. 2020 Jul;40(7):1713-1724. doi: 10.1111/liv.14498. Epub 2020 May 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32358998/

2020

Brusilovskaya K, Königshofer P, Lampach D, Szodl A, Supper P, Bauer D, Beer A, Stift J, Timelthaler G, Oberhuber G, Podesser BK, Seif M, Zinober K, Rohr-Udilova N, Trauner M, Reiberger T, Schwabl P. Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct-ligated rats. United European Gastroenterol J. 2020 Dec;8(10):1174-1185. doi: 10.1177/2050640620944140. Epub 2020 Sep 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32878579/

2020

Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A. PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Rep. 2020 Dec 3;21(12):e50893. doi: 10.15252/embr.202050893. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33225610/

2020

Simbrunner B, Semmler G, Stadlmann A, Scheiner B, Schwabl P, Paternostro R, Bucsics T, Bauer D, Eigenbauer E, Pinter M, Stättermayer AF, Quehenberger P, Marculescu R, Trauner M, Mandorfer M, Reiberger T. Vitamin A levels reflect disease severity and portal hypertension in patients with cirrhosis. Hepatol Int. 2020 Dec;14(6):1093-1103. doi: 10.1007/s12072-020-10112-3. Epub 2020 Dec 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33289910/

2020

Wöran K, Semmler G, Jachs M, Simbrunner B, Maria Bauer DJ, Binter T, Pomej K, Stättermayer AF, Schwabl P, Bucsics T, Paternostro R, Lampichler K, Pinter M, Trauner M, Mandorfer M, Stift J, Reiberger T, Scheiner B. Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension. Clin Gastroenterol Hepatol. 2020 Dec 3:S1542-3565(20)31629-3. doi: 10.1016/j.cgh.2020.11.039. Epub ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33279774/

2020

Paternostro R, Pfeiffenberger J, Ferenci P, Stättermayer AF, Stauber RE, Wrba F, Longerich T, Lackner K, Trauner M, Ferlitsch A, Reiberger T, Weiss KH. Non-invasive diagnosis of cirrhosis and long-term disease monitoring by transient elastography in patients with Wilson disease. Liver Int. 2020 Apr;40(4):894-904. doi: 10.1111/liv.14368. Epub 2020 Jan 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31898387

2020

Brunner SB, Marculescu R, Scheiner B, Schwabl P, Bucsics T, Stadlmann A, Bauer DJM, Paternostro R, Eigenbauer E, Pinter M, Stättermayer AF, Trauner M, Mandorfer M, Reiberger T. Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease. Liver Int. 2020 May 2. doi: 10.1111/liv.14498. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32358998

2019

Semmler G, Simbrunner B, Scheiner B, Schwabl P, Paternostro R, Bucsics T,Stättermayer AF, Bauer D, Pinter M, Ferenci P, Trauner M, Mandorfer M, Reiberger T. Impact of farnesoid X receptor single nucleotide polymorphisms on hepatic decompensation and mortality in cirrhotic patients with portal hypertension. JGastroenterol Hepatol. 2019 May 6. doi: 10.1111/jgh.14700. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31062417