Single-cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation

Mathias Declercq, Lucas Treps, Vincent Geldhof, Nadine V Conchinha, Laura P M H de Rooij, Abhishek Subramanian, Magalie Feyeux, Marine Cotinat, Bram Boeckx, Stefan Vinckier, Lieven Dupont, Francois Vermeulen, Mieke Boon, Marijke Proesmans, Louis Libbrecht, Jacques Pirenne, Diethard Monbaliu, Ina Jochmans, Mieke Dewerchin, Guy Eelen, Tania Roskams, Stijn Verleden, Diether Lambrechts, Peter Carmeliet, Peter Witters.
Liver Int. 2024 Jun 7. doi: 10.1111/liv.15963. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38847551/

In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods

Fanni Tóth, Zahra Moftakhar, Federica Sotgia, Michael P Lisanti.
Cells. 2024 May 15;13(10):841. doi: 10.3390/cells13100841.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38786063/

Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F Baumert, Joachim Lupberger, Michael Trauner, Stefan G Kauschke, Larissa Pfisterer, Eric Simon, André F Rendeiro, Laura P M H de Rooij, Philipp Schwabl, Thomas Reiberger.
iScience. 2024 Feb 20;27(3):109301. doi: 10.1016/j.isci.2024.109301. eCollection 2024 Mar 15.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38469563/

A high-resolution view of the heterogeneous aging endothelium

Sarah Dobner, Fanni Tóth, Laura P M H de Rooij.
Angiogenesis. 2024 May;27(2):129-145. doi: 10.1007/s10456-023-09904-6. Epub 2024 Feb 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38324119/

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Ibrahim AlZaim, Laura P M H de Rooij, Bilal N Sheikh, Emma Börgeson, Joanna Kalucka.
Nat Rev Endocrinol. 2023 Dec;19(12):691-707. doi: 10.1038/s41574-023-00893-6. Epub 2023 Sep 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37749386/

Prioritization and functional validation of target genes from single-cell transcriptomics studies

Liliana Sokol, Anne Cuypers, Anh-Co K Truong, Ann Bouché, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P M H de Rooij, Peter Carmeliet.
Commun Biol. 2023 Jun 17;6(1):648. doi: 10.1038/s42003-023-05006-7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37330599/

In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target

Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A Yee, Sampath K Loganathan, Lina Liu, Derek C H Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E Dick, Mark D Minden, Daniel Schramek, Gene W Yeo, Kristin J Hope.
Blood Cancer Discov. 2023 Feb 10:BCD-22-0086. doi: 10.1158/2643-3230.BCD-22-0086. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36763002/

Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast.

Vincent Geldhof, Laura P M H de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li, Yonglun Luo, Peter Carmeliet.
Nat Commun. 2022 Sep 20;13(1):5511. doi: 10.1038/s41467-022-33052-y.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36127427/