Groups

YearPaper
2019 Brand M, Winter GE. Stick it to E3s. Nat Chem Biol. 2019 Jul;15(7):655-656.doi: 10.1038/s41589-019-0312-8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31209352
2019 Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC,Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi:10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30595531
2019 Brand M, Winter GE. Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies. Methods Mol Biol. 2019;1953:105-119. doi:10.1007/978-1-4939-9145-7_7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30912018
2019 Mayor-Ruiz C, Winter GE. Identification and characterization of cancer vulnerabilities via targeted protein degradation. Drug Discov Today Technol. 2019Apr;31:81-90. doi: 10.1016/j.ddtec.2018.12.003. Epub 2019 Jan 2. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31200863.
2019 Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G,Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P,Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL,Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, MechtlerK, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J,Kubicek S. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133746
2019 Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells. Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/
2019 Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31442425/
2020 Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G. Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Cell Chem Biol. 2020 Apr 18. pii: S2451-9456(20)30117-3. doi: 10.1016/j.chembiol.2020.04.003. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32386596
2020 Hanzl A, Winter GE. Targeted protein degradation: current and future challenges. Curr Opin Chem Biol. 2020 Jan 2;56:35-41. doi: 10.1016/j.cbpa.2019.11.012. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31901786
2020 Jaeger MG, Winter GE. Expanding the Degradable Proteome: Designing PROTACs by the Book. Cell Chem Biol. 2020 Jan 16;27(1):14-16. doi: 10.1016/j.chembiol.2019.12.009.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31951815
2020 Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler B, Gray NS, Bradner JB, Bock C, Hnisz D, Cramer P, Winter GE. Selective Mediator Dependence of Cell-Type-Specifying Transcription. Nat Genet. 2020 Jun 1. doi: 10.1038/s41588-020-0635-0. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32483291/
2020 C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, IH Kaltheuner, E Hahn, K Seiler, A Koren, G Petzold, M Fellner, C Bock, AC Müller, J Zuber, M Geyer, NH Thomä, S Kubicek, G E Winter. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207.
doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32747809/