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Year
Paper
2024

A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia

Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Kerstin Heindl, Stefanie Weiss, Thomas Eder, Sayantanee Dutta, Uwe Graichen, Sascha Klee, Omar Sharif, Rotraud Wieser, Balázs Győrffy, Valeria Poli, Emilio Casanova, Heinz Sill, Florian Grebien, Dagmar Stoiber.
Cell Death Dis. 2024 May 28;15(5):369. doi: 10.1038/s41419-024-06749-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38806478/
2024

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W Zimmerman, Thomas Eder, Diaaeldin I Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Daniel Pölöske, Emina Hubanic, Dennis Jungherz, Tony Andreas Müller, Myint Myat Khine Aung, Anna Orlova, Ha Thi Thanh Pham, Kerstin Zimmel, Thomas Krausgruber, Christoph Bock, Mathias Müller, Maik Dahlhoff, Auke Boersma, Thomas Rülicke, Roman Fleck, Elvin Dominic de Araujo, Patrick Thomas Gunning, Tero Aittokallio, Satu Mustjoki, Takaomi Sanda, Sylvia Hartmann, Florian Grebien, Gregor Hoermann, Torsten Haferlach, Philipp Bernhard Staber, Heidi Anne Neubauer, Alfred Thomas Look, Marco Herling, Richard Moriggl.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38618957/
2021

Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions

Peter Valent, Alberto Orfao, Stefan Kubicek, Philipp Staber, Torsten Haferlach, Michael Deininger, Karoline Kollmann, Thomas Lion, Irene Virgolini, Georg Winter, Oliver Hantschel, Lukas Kenner, Johannes Zuber, Florian Grebien, Richard Moriggl, Gregor Hoermann, Olivier Hermine, Michael Andreeff, Christoph Bock, Tariq Mughal, Stefan N Constantinescu, Robert Kralovics, Veronika Sexl, Radek Skoda, Giulio Superti-Furga, Ulrich Jäger.
Hemasphere. 2021 Feb 17;5(3):e536. doi: 10.1097/HS9.0000000000000536. eCollection 2021 Mar.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33623882/
2021

Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression

Stefan Terlecki-Zaniewicz, Theresa Humer, Thomas Eder, Johannes Schmoellerl, Elizabeth Heyes, Gabriele Manhart, Natalie Kuchynka, Katja Parapatics, Fabio G Liberante, André C Müller, Eleni M Tomazou, Florian Grebien.
Nat Struct Mol Biol. 2021 Feb;28(2):190-201. doi: 10.1038/s41594-020-00550-w. Epub 2021 Jan 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33479542/
2019

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha T T Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave N T Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar, Richard Moriggl.
Cell Death Dis. 2019 Aug 13;10(8):605. doi: 10.1038/s41419-019-1853-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31406155/
2019

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Thanh Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl.
Haematologica. 2020 Jan 31;105(2):435-447. doi: 10.3324/haematol.2019.216986. Print 2020.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31123029/
2019

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis

Afsar A Mian, Ines Baumann, Marcus Liebermann, Florian Grebien, Giulio Superti-Furga, Martin Ruthardt, Oliver G Ottmann, Oliver Hantschel.
Leukemia. 2019 Sep;33(9):2319-2323. doi: 10.1038/s41375-019-0468-y. Epub 2019 Apr 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30962580/
2019

Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond

Anna Skucha, Jessica Ebner, Florian Grebien.
Int J Mol Sci. 2019 Feb 27;20(5):1029. doi: 10.3390/ijms20051029.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30818762/
2018

SETD2 in MLL-rearranged leukemia - a complex case

Anna Skucha, Jessica Ebner, Florian Grebien.
Mol Cell Oncol. 2018 Aug 13;5(4):e1503492. doi: 10.1080/23723556.2018.1503492. eCollection 2018.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30250934/
2018

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, None Jan Pencik, Ha T T Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave N T Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar, Richard Moriggl.
Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30038364/
2018

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C Müller, Balázs Győrffy, Christopher R Vakoc, Peter Valent, Keiryn L Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien.
Nat Commun. 2018 May 18;9(1):1983. doi: 10.1038/s41467-018-04329-y.
Abstract: https://pubmed.ncbi.nlm.nih.gov/29777171/
2018

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

Bettina Wingelhofer, Barbara Maurer, Elizabeth C Heyes, Abbarna A Cumaraswamy, Angelika Berger-Becvar, Elvin D de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, Charles-Hugues Lardeau, Irina Sadovnik, Dávid Bajusz, György Miklós Keserű, Florian Grebien, Stefan Kubicek, Peter Valent, Patrick T Gunning, Richard Moriggl.
Leukemia. 2018 May;32(5):1135-1146. doi: 10.1038/s41375-017-0005-9. Epub 2018 Feb 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/29472718/
2017

STAT5BN642H is a driver mutation for T cell neoplasia

Ha Thi Thanh Pham, Barbara Maurer, Michaela Prchal-Murphy, Reinhard Grausenburger, Eva Grundschober, Tahereh Javaheri, Harini Nivarthi, Auke Boersma, Thomas Kolbe, Mohamed Elabd, Florian Halbritter, Jan Pencik, Zahra Kazemi, Florian Grebien, Markus Hengstschläger, Lukas Kenner, Stefan Kubicek, Matthias Farlik, Christoph Bock, Peter Valent, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl.
J Clin Invest. 2018 Jan 2;128(1):387-401. doi: 10.1172/JCI94509. Epub 2017 Dec 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/29200404/
2017

Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site

E Hadzijusufovic, K Albrecht-Schgoer, K Huber, G Hoermann, F Grebien, G Eisenwort, W Schgoer, S Herndlhofer, C Kaun, M Theurl, W R Sperr, U Rix, I Sadovnik, B Jilma, G H Schernthaner, J Wojta, D Wolf, G Superti-Furga, R Kirchmair, P Valent.
Leukemia. 2017 Nov;31(11):2388-2397. doi: 10.1038/leu.2017.245. Epub 2017 Jul 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/28757617/
2016

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha Tt Pham, Maximilian Kauer, Rahil Noorizadeh, Barbara Sax, Harini Nivarthi, Michaela Schlederer, Barbara Maurer, Maximillian Hofbauer, Dave Nt Aryee, Marc Wiedner, Eleni M Tomazou, Malcolm Logan, Christine Hartmann, Jan P Tuckermann, Lukas Kenner, Mario Mikula, Helmut Dolznig, Aykut Üren, Günther H Richter, Florian Grebien, Heinrich Kovar, Richard Moriggl.
Cell Death Dis. 2016 Oct 13;7(10):e2419. doi: 10.1038/cddis.2016.268.
Abstract: https://pubmed.ncbi.nlm.nih.gov/27735950/
2015

STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M Walker, Athena Chalaris, Isabelle J Marié, Melanie R Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits, Robert Eferl, Harald Esterbauer, Richard Kennedy, Falko Fend, Marcus Scharpf, Martin Braun, Sven Perner, David E Levy, Tim Malcolm, Suzanne D Turner, Andrea Haitel, Martin Susani, Ali Moazzami, Stefan Rose-John, Fritz Aberger, Olaf Merkel, Richard Moriggl, Zoran Culig, Helmut Dolznig, Lukas Kenner.
Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736.
Abstract: https://pubmed.ncbi.nlm.nih.gov/26198641/
2015

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V M Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J Brown, Johannes Zuber, Keiryn L Bennett, Rima Al-Awar, Ruud Delwel, Claus Nerlov, Cheryl H Arrowsmith, Giulio Superti-Furga.
Nat Chem Biol. 2015 Aug;11(8):571-578. doi: 10.1038/nchembio.1859. Epub 2015 Jul 13.
Abstract: https://pubmed.ncbi.nlm.nih.gov/26167872/
2013

Affinity purification strategies for proteomic analysis of transcription factor complexes

Roberto Giambruno, Florian Grebien, Alexey Stukalov, Christian Knoll, Melanie Planyavsky, Elena L Rudashevskaya, Jacques Colinge, Giulio Superti-Furga, Keiryn L Bennett.
J Proteome Res. 2013 Sep 6;12(9):4018-27. doi: 10.1021/pr4003323. Epub 2013 Aug 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/23937658/
2012

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

Georg E Winter, Uwe Rix, Scott M Carlson, Karoline V Gleixner, Florian Grebien, Manuela Gridling, André C Müller, Florian P Breitwieser, Martin Bilban, Jacques Colinge, Peter Valent, Keiryn L Bennett, Forest M White, Giulio Superti-Furga.
Nat Chem Biol. 2012 Nov;8(11):905-912. doi: 10.1038/nchembio.1085. Epub 2012 Sep 30.
Abstract: https://pubmed.ncbi.nlm.nih.gov/23023260/
2012

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

Oliver Hantschel, Wolfgang Warsch, Eva Eckelhart, Ines Kaupe, Florian Grebien, Kay-Uwe Wagner, Giulio Superti-Furga, Veronika Sexl.
Nat Chem Biol. 2012 Jan 29;8(3):285-93. doi: 10.1038/nchembio.775.
Abstract: https://pubmed.ncbi.nlm.nih.gov/22286129/
2010

Using iTRAQ combined with tandem affinity purification to enhance low-abundance proteins associated with somatically mutated EGFR core complexes in lung cancer

Eric B Haura, André Müller, Florian P Breitwieser, Jiannong Li, Florian Grebien, Jacques Colinge, Keiryn L Bennett.
J Proteome Res. 2011 Jan 7;10(1):182-90. doi: 10.1021/pr100863f. Epub 2010 Nov 9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/20945942/