Publications
2025
Protecting centrosomes from fracturing enables efficient cell navigation
Madeleine T Schmitt,
Janina Kroll,
Mauricio J A Ruiz-Fernandez,
Robert Hauschild,
Shaunak Ghosh,
Petra Kameritsch,
Jack Merrin,
Johanna Schmid,
Kasia Stefanowski,
Andreas W Thomae,
Jingyuan Cheng,
Gamze Naz Öztan,
Peter Konopka,
Germán Camargo Ortega,
Thomas Penz,
Luisa Bach,
Dirk Baumjohann,
Christoph Bock,
Tobias Straub,
Felix Meissner,
Eva Kiermaier,
Jörg Renkawitz.
Sci Adv. 2025 Apr 25;11(17):eadx4047. doi: 10.1126/sciadv.adx4047. Epub 2025 Apr 25.
2025
Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma
Matarr Khan,
Marlis Alteneder,
Wolfgang Reiter,
Thomas Krausgruber,
Lina Dobnikar,
Moritz Madern,
Monika Waldherr,
Christoph Bock,
Markus Hartl,
Wilfried Ellmeier,
Johan Henriksson,
Nicole Boucheron.
Nat Commun. 2025 Mar 15;16(1):2565. doi: 10.1038/s41467-025-57590-3.
2025
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation
Ci Zhu,
Nicole Boucheron,
Osamah Al-Rubaye,
Brian K Chung,
Liv Wenche Thorbjørnsen,
Thomas Köcher,
Michael Schuster,
Thierry Claudel,
Emina Halilbasic,
Victoria Kunczer,
Fanziska Muscate,
Lois L Cavanagh,
Darina Waltenberger,
Alexander Lercher,
Anna Ohradanova-Repic,
Philipp Schatzlmaier,
Tatjana Stojakovic,
Hubert Scharnagl,
Andreas Bergthaler,
Hannes Stockinger,
Samuel Huber,
Christoph Bock,
Lukas Kenner,
Tom H Karlsen,
Wilfried Ellmeier,
Michael Trauner.
Gut. 2025 Mar 7:gutjnl-2024-333297. doi: 10.1136/gutjnl-2024-333297. Online ahead of print.
2025
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions
Anzhelika Karjalainen,
Agnieszka Witalisz-Siepracka,
Michaela Prchal-Murphy,
David Martin,
Felix Sternberg,
Milica Krunic,
Marlies Dolezal,
Nikolaus Fortelny,
Matthias Farlik,
Sabine Macho-Maschler,
Caroline Lassnig,
Katrin Meissl,
Lena Amenitsch,
Therese Lederer,
Elena Pohl,
Dagmar Gotthardt,
Christoph Bock,
Thomas Decker,
Birgit Strobl,
Mathias Müller.
Cell Mol Life Sci. 2025 Mar 2;82(1):98. doi: 10.1007/s00018-025-05625-9.
2025
Altered spawning seasons of Atlantic salmon broodstock transcriptionally and epigenetically influence cell cycle and lipid-mediated regulations in their offspring
Takaya Saito,
Marit Espe,
Maren Mommens,
Christoph Bock,
Jorge M O Fernandes,
Kaja Helvik Skjærven.
PLoS One. 2025 Feb 24;20(2):e0317770. doi: 10.1371/journal.pone.0317770. eCollection 2025.
2025
Single-cell CRISPR screening in mouse brain
Eugenia V Pankevich,
Christoph Bock.
Nat Protoc. 2025 Feb 12. doi: 10.1038/s41596-024-01128-2. Online ahead of print.
2024
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Valentina Stolz,
Rafael de Freitas E Silva,
Ramona Rica,
Ci Zhu,
Teresa Preglej,
Patricia Hamminger,
Daniela Hainberger,
Marlis Alteneder,
Lena Müller,
Monika Waldherr,
Darina Waltenberger,
Anastasiya Hladik,
Benedikt Agerer,
Michael Schuster,
Tobias Frey,
Thomas Krausgruber,
Sylvia Knapp,
Clarissa Campbell,
Klaus Schmetterer,
Michael Trauner,
Andreas Bergthaler,
Christoph Bock,
Nicole Boucheron,
Wilfried Ellmeier.
Elife. 2024 Oct 28;13:e78738. doi: 10.7554/eLife.78738.
2024
Insights into the multifaceted role of interleukin-37 on human immune cell regulation
Lisa U Teufel,
Vasiliki Matzaraki,
Lukas Folkman,
Rob Ter Horst,
Simone J C F M Moorlag,
Catharina M Mulders-Manders,
Mihai G Netea,
Thomas Krausgruber,
Leo A B Joosten,
Rob J W Arts.
Clin Immunol. 2024 Nov;268:110368. doi: 10.1016/j.clim.2024.110368. Epub 2024 Sep 20.
2024
GPT-4 as a biomedical simulator
Moritz Schaefer,
Stephan Reichl,
Rob Ter Horst,
Adele M Nicolas,
Thomas Krausgruber,
Francesco Piras,
Peter Stepper,
Christoph Bock,
Matthias Samwald.
Comput Biol Med. 2024 Aug;178:108796. doi: 10.1016/j.compbiomed.2024.108796. Epub 2024 Jun 22.
2024
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
Leon U B Enk,
Malte Hellmig,
Kristoffer Riecken,
Christoph Kilian,
Paul Datlinger,
Saskia L Jauch-Speer,
Tobias Neben,
Zeba Sultana,
Varshi Sivayoganathan,
Alina Borchers,
Hans-Joachim Paust,
Yu Zhao,
Nariaki Asada,
Shuya Liu,
Theodora Agalioti,
Penelope Pelczar,
Thorsten Wiech,
Christoph Bock,
Tobias B Huber,
Samuel Huber,
Stefan Bonn,
Nicola Gagliani,
Boris Fehse,
Ulf Panzer,
Christian F Krebs.
Sci Immunol. 2024 Jun 14;9(96):eadd6774. doi: 10.1126/sciimmunol.add6774. Epub 2024 Jun 14.
