Jühling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Gut. 2021 Jan;70(1):157-169. doi: 10.1136/gutjnl-2019-318918. Epub 2020 Mar 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32217639/

Kretzmer H, Biran A, Purroy N, Lemvigh C, Clement K, Gruber M, Gu H, Rassenti L, Mohammad AW, Lesnick C, Slager SL, Braggio E, Shanafelt TD, Kay NE, Fernandes S, Brown JR, Wang L, Li S, Livak KJ, Neuberg DS, Klages S, Timmermann B, Kipps TJ, Campo E, Gnirke A, Wu CJ, Meissner A. Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy. Blood Cancer Discov. 2021 Jan;2(1):54-69. doi: 10.1158/2643-3230.BCD-19-0058. Epub 2020 Dec 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33604581/

Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis. Life Sci Alliance. 2020 Dec 11;4(2):e202000794. doi: 10.26508/lsa.202000794. Print 2021 Feb.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33310759/

Swoboda A, Soukup R, Eckel O, Kinslechner K, Wingelhofer B, Schörghofer D, Sternberg C, Pham HTT, Vallianou M, Horvath J, Stoiber D, Kenner L, Larue L, Poli V, Beermann F, Yokota T, Kubicek S, Krausgruber T, Rendeiro AF, Bock C, Zenz R, Kovacic B, Aberger F, Hengstschläger M, Petzelbauer P, Mikula M, Moriggl R. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway. Oncogene. 2021 Feb;40(6):1091-1105. doi: 10.1038/s41388-020-01584-6. Epub 2020 Dec 15.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33323974/

Paolino M, Koglgruber R, Cronin SJF, Uribesalgo I, Rauscher E, Harreiter J, Schuster M, Bancher-Todesca D, Pranjic B, Novatchkova M, Fededa JP, White AJ, Sigl V, Dekan S, Penz T, Bock C, Kenner L, Holländer GA, Anderson G, Kautzky-Willer A, Penninger JM. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 2021 Jan;589(7842):442-447. doi: 10.1038/s41586-020-03071-0. Epub 2020 Dec 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33361811/

Bock C, Boutros M, Camp JG, Clarke L, Clevers H, Knoblich JA, Liberali P, Regev A, Rios AC, Stegle O, Stunnenberg HG, Teichmann SA, Treutlein B, Vries RGJ; Human Cell Atlas ‘Biological Network’ Organoids. The Organoid Cell Atlas. Nat Biotechnol. 2021 Jan;39(1):13-17. doi: 10.1038/s41587-020-00762-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33384458/

Thomas HF, Kotova E, Jayaram S, Pilz A, Romeike M, Lackner A, Penz T, Bock C, Leeb M, Halbritter F, Wysocka J, Buecker C. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements. Mol Cell. 2021 Mar 4;81(5):969-982.e13. doi: 10.1016/j.molcel.2020.12.047. Epub 2021 Jan 21.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33482114/

Bangert C, Rindler K, Krausgruber T, Alkon N, Thaler FM, Kurz H, Ayub T, Demirtas D, Fortelny N, Vorstandlechner V, Bauer WM, Quint T, Mildner M, Jonak C, Elbe-Bürger A, Griss J, Bock C, Brunner PM. Persistence of mature dendritic cells, T(H)2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade. Sci Immunol. 2021 Jan 22;6(55):eabe2749. doi: 10.1126/sciimmunol.abe2749.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33483337/

Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab. 2021 Feb;3(2):149-165. doi: 10.1038/s42255-021-00347-1. Epub 2021 Feb 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33536639/

Schick S, Grosche S, Kohl KE, Drpic D, Jaeger MG, Marella NC, Imrichova H, Lin JG, Hofstätter G, Schuster M, Rendeiro AF, Koren A, Petronczki M, Bock C, Müller AC, Winter GE, Kubicek S. Acute BAF perturbation causes immediate changes in chromatin accessibility. Nat Genet. 2021 Mar;53(3):269-278. doi: 10.1038/s41588-021-00777-3. Epub 2021 Feb 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33558760/

Steindl A, Alpar D, Heller G, Mair MJ, Gatterbauer B, Dieckmann K, Widhalm G, Hainfellner JA, Schmidinger M, Bock C, Müllauer L, Preusser M, Berghoff AS. Tumor mutational burden and immune infiltrates in renal cell carcinoma and matched brain metastases. ESMO Open. 2021 Apr;6(2):100057. doi: 10.1016/j.esmoop.2021.100057. Epub 2021 Feb 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33588158/

Berg JL, Perfler B, Hatzl S, Uhl B, Reinisch A, Pregartner G, Berghold A, Penz T, Schuster M, Geissler K, Prokesch A, Müller-Tidow C, Hoefler G, Kashofer K, Wölfler A, Sill H, Caraffini V, Zebisch A. EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity. Leukemia. 2021 Feb 15. doi: 10.1038/s41375-021-01161-0. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33589750/

Valent P, Orfao A, Kubicek S, Staber P, Haferlach T, Deininger M, Kollmann K, Lion T, Virgolini I, Winter G, Hantschel O, Kenner L, Zuber J, Grebien F, Moriggl R, Hoermann G, Hermine O, Andreeff M, Bock C, Mughal T, Constantinescu SN, Kralovics R, Sexl V, Skoda R, Superti-Furga G, Jäger U. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions. Hemasphere. 2021 Feb 17;5(3):e536. doi: 10.1097/HS9.0000000000000536. eCollection 2021 Mar.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33623882/

Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. Histone deacetylase 1 controls CD4(+) T cell trafficking in autoinflammatory diseases. J Autoimmun. 2021 May;119:102610. doi: 10.1016/j.jaut.2021.102610. Epub 2021 Feb 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33621930/

Rindler K, Krausgruber T, Thaler FM, Alkon N, Bangert C, Kurz H, Fortelny N, Rojahn TB, Jonak C, Griss J, Bock C, Brunner PM. Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct From Healthy Control Skin. Front Immunol. 2021 Feb 24;12:630892. doi: 10.3389/fimmu.2021.630892. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33717163/

Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2021 Mar;17(3):361. doi: 10.1038/s41589-021-00735-4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33452497/

Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33664060/

Gülich AF, Rica R, Tizian C, Viczenczova C, Khamina K, Faux T, Hainberger D, Penz T, Bosselut R, Bock C, Laiho A, Elo LL, Bergthaler A, Ellmeier W, Sakaguchi S. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. Front Immunol. 2021 Mar 17;12:535039. doi: 10.3389/fimmu.2021.535039. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33815354/

Achyutuni S, Nivarthi H, Majoros A, Hug E, Schueller C, Jia R, Varga C, Schuster M, Senekowitsch M, Tsiantoulas D, Kavirayani A, Binder CJ, Bock C, Zagrijtschuk O, Kralovics R. Hematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivo. Am J Hematol. 2021 Mar 24. doi: 10.1002/ajh.26171. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33761144/

Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. 2021 Apr;592(7852):E8. doi: 10.1038/s41586-021-03287-8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33731935/

Reitermaier R, Krausgruber T, Fortelny N, Ayub T, Vieyra-Garcia PA, Kienzl P, Wolf P, Scharrer A, Fiala C, Kölz M, Hiess M, Vierhapper M, Schuster C, Spittler A, Worda C, Weninger W, Bock C, Eppel W, Elbe-Bürger A. αβγδ T cells play a vital role in fetal human skin development and immunity. J Exp Med. 2021 Apr 5;218(4):e20201189. doi: 10.1084/jem.20201189.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33561194/

Strobl J, Pandey RV, Krausgruber T, Kleissl L, Reininger B, Herac M, Bayer N, Krall C, Wohlfarth P, Mitterbauer M, Kalhs P, Rabitsch W, Bock C, Hopfinger G, Stary G. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease. J Invest Dermatol. 2020 Nov;140(11):2188-2198. doi: 10.1016/j.jid.2020.02.029. Epub 2020 Apr 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32247860/

Rojahn TB, Vorstandlechner V, Krausgruber T, Bauer WM, Alkon N, Bangert C, Thaler FM, Sadeghyar F, Fortelny N, Gernedl V, Rindler K, Elbe-Bürger A, Bock C, Mildner M, Brunner PM. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type-specific immune regulation in atopic dermatitis. J Allergy Clin Immunol. 2020 Nov;146(5):1056-1069. doi: 10.1016/j.jaci.2020.03.041. Epub 2020 Apr 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32344053/

Romanov RA, Tretiakov EO, Kastriti ME, Zupancic M, Häring M, Korchynska S, Popadin K, Benevento M, Rebernik P, Lallemend F, Nishimori K, Clotman F, Andrews WD, Parnavelas JG, Farlik M, Bock C, Adameyko I, Hökfelt T, Keimpema E, Harkany T. Molecular design of hypothalamus development. Nature. 2020 Jun;582(7811):246-252. doi: 10.1038/s41586-020-2266-0. Epub 2020 May 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32499648/

Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GE. Selective Mediator dependence of cell-type-specifying transcription. Nat Genet. 2020 Jul;52(7):719-727. doi: 10.1038/s41588-020-0635-0. Epub 2020 Jun 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32483291/

Hubmann R, Schnabl S, Araghi M, Schmidl C, Rendeiro AF, Hilgarth M, Demirtas D, Ali F, Staber PB, Valent P, Zielinski C, Jäger U, Shehata M. Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL. Cells. 2020 Jun 18;9(6):1484. doi: 10.3390/cells9061484.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32570839/

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C. Structural cells are key regulators of organ-specific immune responses. Nature. 2020 Jul;583(7815):296-302. doi: 10.1038/s41586-020-2424-4. Epub 2020 Jul 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32612232/

Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt M, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Sci Immunol. 2020 Jul 10;5(49):eabc3979. doi: 10.1126/sciimmunol.abc3979.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32646852/

Akgün M, Ünal AB, Ergüner B, Pfeifer N, Kohlbacher O. Identifying Disease-Causing Mutations with Privacy Protection. Bioinformatics. 2020 Jul 19;36(21):5205–13. doi: 10.1093/bioinformatics/btaa641. Epub ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32683440/

Laukoter S, Pauler FM, Beattie R, Amberg N, Hansen AH, Streicher C, Penz T, Bock C, Hippenmeyer S. Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex. Neuron. 2020 Sep 23;107(6):1160-1179.e9. doi: 10.1016/j.neuron.2020.06.031. Epub 2020 Jul 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32707083/

Fortelny N, Bock C. Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data. Genome Biol. 2020 Aug 3;21(1):190. doi: 10.1186/s13059-020-02100-5.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32746932/

Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Erratum in: Nat Chem Biol. 2021 Mar;17(3):361.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32747809/

Kreidl P, Schmid D, Maritschnik S, Richter L, Borena W, Genger JW, Popa A, Penz T, Bock C, Bergthaler A, Allerberger F. Emergence of coronavirus disease 2019 (COVID-19) in Austria. Wien Klin Wochenschr. 2020 Nov;132(21-22):645-652. doi: 10.1007/s00508-020-01723-9. Epub 2020 Aug 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32816114/

Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, Thorball C, Duc J, Pankevich EV, Deplancke B, Busskamp V, Trono D. Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Sci Adv. 2020 Aug 28;6(35):eaba3200. doi: 10.1126/sciadv.aba3200.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32923624/

Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. 2020 Nov;587(7834):377-386. doi: 10.1038/s41586-020-2715-9. Epub 2020 Sep 7. Erratum in: Nature. 2021 Apr;592(7852):E8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32894860/

Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L, San Martin-Uriz P, Lorenzo-Vivas E, García-Olloqui P, Palacio M, Gavira JJ, Bastarrika G, Janssens S, Wu M, Iglesias E, Abizanda G, de Morentin XM, Lasaga M, Planell N, Bock C, Alignani D, Medal G, Prudovsky I, Jin YR, Ryzhov S, Yin H, Pelacho B, Gomez-Cabrero D, Lindner V, Lara-Astiaso D, Prósper F. Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. Circulation. 2020 Nov 10;142(19):1831-1847. doi: 10.1161/CIRCULATIONAHA.119.044557. Epub 2020 Sep 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32972203/

Dobon B, Ter Horst R, Laayouni H, Mondal M, Bianco E, Comas D, Ioana M, Bosch E, Bertranpetit J, Netea MG. The shaping of immunological responses through natural selection after the Roma Diaspora. Sci Rep. 2020 Sep 30;10(1):16134. doi: 10.1038/s41598-020-73182-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32999407/

de Bree LCJ, Mourits VP, Koeken VA, Moorlag SJ, Janssen R, Folkman L, Barreca D, Krausgruber T, Fife-Gernedl V, Novakovic B, Arts RJ, Dijkstra H, Lemmers H, Bock C, Joosten LA, van Crevel R, Benn CS, Netea MG. Circadian rhythm influences induction of trained immunity by BCG vaccination. J Clin Invest. 2020 Oct 1;130(10):5603-5617. doi: 10.1172/JCI133934.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32692732/

Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, Rincon-Restrepo M, Franco F, Genolet R, Cheng WC, Jandus C, Coukos G, Jiang YF, Locasale JW, Zippelius A, Liu PS, Tang L, Bock C, Vannini N, Ho PC. Disturbed mitochondrial dynamics in CD8(+) TILs reinforce T cell exhaustion. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33020660/

Stary V, Pandey RV, Strobl J, Kleissl L, Starlinger P, Pereyra D, Weninger W, Fischer GF, Bock C, Farlik M, Stary G. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses. Sci Immunol. 2020 Oct 16;5(52):eaba6232. doi: 10.1126/sciimmunol.aba6232.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33067380/

Nenning KH, Furtner J, Kiesel B, Schwartz E, Roetzer T, Fortelny N, Bock C, Grisold A, Marko M, Leutmezer F, Liu H, Golland P, Stoecklein S, Hainfellner JA, Kasprian G, Prayer D, Marosi C, Widhalm G, Woehrer A, Langs G. Distributed changes of the functional connectome in patients with glioblastoma. Sci Rep. 2020 Oct 27;10(1):18312. doi: 10.1038/s41598-020-74726-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33110138/

Strobl J, Pandey RV, Krausgruber T, Bayer N, Kleissl L, Reininger B, Vieyra-Garcia P, Wolf P, Jentus MM, Mitterbauer M, Wohlfarth P, Rabitsch W, Stingl G, Bock C, Stary G. Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease. Sci Transl Med. 2020 Nov 18;12(570):eabb7028. doi: 10.1126/scitranslmed.abb7028.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33208504/

Popa A, Genger JW, Nicholson MD, Penz T, Schmid D, Aberle SW, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau ML, Martínez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Sci Transl Med. 2020 Dec 9;12(573):eabe2555. doi: 10.1126/scitranslmed.abe2555. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33229462/

Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G. Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis. Life Sci Alliance. 2020 Dec 11;4(2):e202000794. doi: 10.26508/lsa.202000794.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33310759/

Swoboda A, Soukup R, Eckel O, Kinslechner K, Wingelhofer B, Schörghofer D, Sternberg C, Pham HTT, Vallianou M, Horvath J, Stoiber D, Kenner L, Larue L, Poli V, Beermann F, Yokota T, Kubicek S, Krausgruber T, Rendeiro AF, Bock C, Zenz R, Kovacic B, Aberger F, Hengstschläger M, Petzelbauer P, Mikula M, Moriggl R. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway. Oncogene. 2021 Feb;40(6):1091-1105. doi: 10.1038/s41388-020-01584-6. Epub 2020 Dec 15.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33323974/

Paolino M, Koglgruber R, Cronin SJF, Uribesalgo I, Rauscher E, Harreiter J, Schuster M, Bancher-Todesca D, Pranjic B, Novatchkova M, Fededa JP, White AJ, Sigl V, Dekan S, Penz T, Bock C, Kenner L, Holländer GA, Anderson G, Kautzky-Willer A, Penninger JM. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 2021 Jan;589(7842):442-447. doi: 10.1038/s41586-020-03071-0. Epub 2020 Dec 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33361811/

Popa A, Genger J-W, Nicholson M D, Penz T, Schmid D, Aberle S W, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau M L, Martínez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle J H, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger M T, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Sci Transl Med. 2020 Nov 23;eabe2555. doi: 10.1126/scitranslmed.abe2555. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33229462/

Kreidl P, Schmid D, Maritschnik S, Richter L, Borena W, Genger JW, Popa A, Penz T, Bock C, Bergthaler A, Allerberger F. Emergence of coronavirus disease 2019 (COVID-19) in Austria. Wien Klin Wochenschr. 2020 Aug 20;1-8. doi: 10.1007/s00508-020-01723-9. Online ahead of print. 
Abstract: https://pubmed.ncbi.nlm.nih.gov/32816114/

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C. Structural cells are key regulators of organ-specific immune responses. Nature. 2020 Jul;583(7815):296-302. doi: 10.1038/s41586-020-2424-4. Epub 2020 Jul 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32612232/

Hainberger D, Stolz V, Zhu C, Schuster M, Müller L, Hamminger P, Rica R, Waltenberger D, Alteneder M, Krausgruber T, Hladik A, Knapp S, Bock C, Trauner M, Farrar MA, Ellmeier W. NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells. Front Immunol. 2020 Apr 3;11:579. doi: 10.3389/fimmu.2020.00579.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32318068

Ulz P, Perakis S, Zhou Q, Moser T, Belic J, Lazzeri I, Wölfler A, Zebisch A, Gerger A, Pristauz G, Petru E, White B, Roberts CES, John JS, Schimek MG, Geigl JB, Bauernhofer T, Sill H, Bock C, Heitzer E, Speicher MR. Publisher Correction: Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection. Nat Commun. 2020 Apr 20;11(1):1965. doi: 10.1038/s41467-020-15799-4. Erratum for: Nat Commun. 2019 Oct 11;10(1):4666.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32313081

Rosser EC, Piper CJM, Matei DE, Blair PA, Rendeiro AF, Orford M, Alber DG, Krausgruber T, Catalan D, Klein N, Manson JJ, Drozdov I, Bock C, Wedderburn LR, Eaton S, Mauri C. Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells. Cell Metab. 2020 Apr 7;31(4):837-851.e10. doi: 10.1016/j.cmet.2020.03.003. Epub 2020 Mar 25.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32213346

Szymczak S, Dose J, Torres GG, Heinsen FA, Venkatesh G, Datlinger P, Nygaard M, Mengel-From J, Flachsbart F, Klapper W, Christensen K, Lieb W, Schreiber S, Häsler R, Bock C, Franke A, Nebel A. DNA methylation QTL analysis identifies new regulators of human longevity. Hum Mol Genet. 2020 May 8;29(7):1154-1167. doi: 10.1093/hmg/ddaa033.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32160291

Scherer M, Nebel A, Franke A, Walter J, Lengauer T, Bock C, Müller F, List M. Quantitative comparison of within-sample heterogeneity scores for DNA methylation data. Nucleic Acids Res. 2020 May 7;48(8):e46. doi: 10.1093/nar/gkaa120.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32103242

Preglej T, Hamminger P, Luu M, Bulat T, Andersen L, Göschl L, Stolz V, Rica R, Sandner L, Waltenberger D, Tschismarov R, Faux T, Boenke T, Laiho A, Elo LL, Sakaguchi S, Steiner G, Decker T, Bohle B, Visekruna A, Bock C, Strobl B, Seiser C, Boucheron N, Ellmeier W. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. JCI Insight. 2020 Feb 27;5(4):e133393. doi: 10.1172/jci.insight.133393.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32102981

Delacher M, Imbusch CD, Hotz-Wagenblatt A, Mallm JP, Bauer K, Simon M, Riegel D, Rendeiro AF, Bittner S, Sanderink L, Pant A, Schmidleithner L, Braband KL, Echtenachter B, Fischer A, Giunchiglia V, Hoffmann P, Edinger M, Bock C, Rehli M, Brors B, Schmidl C, Feuerer M. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Immunity. 2020 Feb 18;52(2):295-312.e11. doi: 10.1016/j.immuni.2019.12.002. Epub 2020 Jan 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31924477

Korchynska S, Krassnitzer M, Malenczyk K, Prasad RB, Tretiakov EO, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger SN, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak DD, Romanov RA, Pifl C, Groop L, Hökfelt TG, Harkany T. Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants. EMBO J. 2020 Jan 2;39(1):e100882. doi: 10.15252/embj.2018100882. Epub 2019 Nov 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31750562

Ilott NE, Bollrath J, Danne C, Schiering C, Shale M, Adelmann K, Krausgruber T, Heger A, Sims D, Powrie F. Correction: Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling. ISME J. 2020 Mar;14(3):879. doi: 10.1038/s41396-019-0539-0. Erratum for: ISME J. 2016 Oct;10(10):2389-404.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31748709

Rojahn TB, Vorstandlechner V, Krausgruber T, Bauer WM, Alkon N, Bangert C, Thaler FM, Sadeghyar F, Fortelny N, Gernedl V, Rindler K, Elbe-Bürger A, Bock C, Mildner M, Brunner PM. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis. J Allergy Clin Immunol. 2020 Apr 25:S0091-6749(20)30556-X. doi: 10.1016/j.jaci.2020.03.041. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32344053

Strobl J, Pandey RV, Krausgruber T, Kleissl L, Reininger B, Herac M, Bayer N, Krall C, Wohlfarth P, Mitterbauer M, Kalhs P, Rabitsch W, Bock C, Hopfinger G, Stary G. Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid- Refractory Graft-Versus-Host Disease. J Invest Dermatol. 2020 Apr 2:S0022-202X(20)31252-5. doi: 10.1016/j.jid.2020.02.029. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32247860

Quijada-Álamo M, Hernández-Sánchez M, Alonso-Pérez V, Rodríguez-Vicente AE, García-Tuñón I, Martín-Izquierdo M, Hernández-Sánchez JM, Herrero AB, Bastida JM, San Segundo L, Gruber M, García JL, Yin S, Ten Hacken E, Benito R, Ordóñez JL, Wu CJ, Hernández-Rivas JM. CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition. Leukemia. 2020 Jan 23. doi: 10.1038/s41375-020-0714-3. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31974435

Cinquina V, Calvigioni D, Farlik M, Halbritter F, Fife-Gernedl V, Shirran SL, Fuszard MA, Botting CH, Poullet P, Piscitelli F, Máté Z, Szabó G, Yanagawa Y, Kasper S, Di Marzo V, Mackie K, McBain CJ, Bock C, Keimpema E, Harkany T. Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy. Mol Psychiatry. 2020 Jan;25(1):22-36. doi: 10.1038/s41380-019-0580-4. Epub 2019 Nov 18.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31735910

Jühling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Gut. 2020 Mar 26:gutjnl-2019-318918. doi: 10.1136/gutjnl-2019-318918. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32217639

Marquina-Sanchez B, Fortelny N, Farlik M, Vieira A, Collombat P, Bock C, Kubicek S. Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets. Genome Biol. 2020 May 6;21(1):106. doi: 10.1186/s13059-020-02006-2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32375897

Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A, Merkel A, Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH, Clarke L, Heath S, van der Reijden BA, Flicek P, Yaspo ML, Gut I, Bock C, Schuringa JJ, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes. Cell Rep. 2019;26(4):1059–1069.e6. doi:10.1016/j.celrep.2018.12.098
Abstract: https://pubmed.ncbi.nlm.nih.gov/30673601/

Uras IZ, Maurer B, Nivarthi H, Jodl P, Kollmann K, Prchal-Murphy M, Milosevic Feenstra JD, Zojer M, Lagger S, Grausenburger R, Grabner B, Holly R, Kavirayani A, Bock C, Gisslinger H, Valent P, Kralovics R, Sexl V. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks. Blood. 2019;133(15):1677–1690. doi:10.1182/blood-2018-08-872648
Abstract: https://pubmed.ncbi.nlm.nih.gov/30635286/

Ulz P, Perakis S, Zhou Q, Moser T, Belic J, Lazzeri I, Wölfler A, Zebisch A, Gerger A, Pristauz G, Petru E, White B, Roberts CES, John JS, Schimek MG, Geigl JB, Bauernhofer T, Sill H, Bock C, Heitzer E, Speicher MR. Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection. Nat Commun. 2019;10(1):4666. Published 2019 Oct 11. doi:10.1038/s41467-019-12714-4
Abstract: https://pubmed.ncbi.nlm.nih.gov/31604930/

Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Májek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Müller AC, Bock C, Kubicek S. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019;51(9):1399–1410. doi:10.1038/s41588-019-0477-9
Abstract: https://pubmed.ncbi.nlm.nih.gov/31427792/

Piper CJM, Rosser EC, Oleinika K, Nistala K, Krausgruber T, Rendeiro AF, Banos A, Drozdov I, Villa M, Thomson S, Xanthou G, Bock C, Stockinger B, Mauri C. Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells. Cell Rep. 2019;29(7):1878–1892.e7. doi:10.1016/j.celrep.2019.10.018
Abstract: https://pubmed.ncbi.nlm.nih.gov/31722204/

Miragaia RJ, Gomes T, Chomka A, Jardine L, Riedel A, Hegazy AN, Whibley N, Tucci A, Chen X, Lindeman I, Emerton G, Krausgruber T, Shields J, Haniffa M, Powrie F, Teichmann SA. Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation. Immunity. 2019 Feb 19;50(2):493-504.e7. doi: 10.1016/j.immuni.2019.01.001.
Abstract: https://pubmed.ncbi.nlm.nih.gov/30737144/

Korchynska S, Krassnitzer M, Malenczyk K, Prasad RB, Tretiakov EO, Rehman S, Cinquina V, Gernedl V, Farlik M, Petersen J, Hannes S, Schachenhofer J, Reisinger SN, Zambon A, Asplund O, Artner I, Keimpema E, Lubec G, Mulder J, Bock C, Pollak DD, Romanov RA, Pifl C, Groop L, Hökfelt TG, Harkany T. Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants [published online ahead of print, 2019 Nov 21]. EMBO J. 2019;e100882. doi:10.15252/embj.2018100882
Abstract: https://pubmed.ncbi.nlm.nih.gov/31750562/

Halbritter F, Farlik M, Schwentner R, Jug G, Fortelny N, Schnöller T, Pisa H, Schuster LC, Reinprecht A, Czech T, Gojo J, Holter W, Minkov M, Bauer W, Simonitsch-Klupp I, Bock C, Hutter C. Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis. Cancer Discov. 2019 Oct;9(10):1406-1421. doi: 10.1158/2159-8290.CD-19-0138.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31345789/

Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10(1):5573. doi: 10.1038/s41467-019-13348-2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31811124/

Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, Maurer-Granofszky M, Roka F, Penz T, Bock C, Zhang G, Herlyn M, Glatz K, Läubli H, Mertz KD, Petzelbauer P, Wiesner T, Hartl M, Pickl WF, Somasundaram R, Steinberger P, Wagner SN. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun. 2019;10(1):4186. Published 2019 Sep 13. doi:10.1038/s41467-019-12160-2
Abstract: https://pubmed.ncbi.nlm.nih.gov/31519915/

Ferreira da Silva J, Salic S, Wiedner M, Datlinger P, Essletzbichler P, Hanzl A, Superti-Furga G, Bock C, Winter G, Loizou JI. Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells. Sci Rep. 2019 Oct 31;9(1):15751. doi: 10.1038/s41598-019-52078-9.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31673055/

Di Giacomo AM, Covre A, Finotello F, Rieder D, Danielli R, Sigalotti L, Giannarelli D, Petitprez F, Lacroix L, Valente M, Cutaia O, Fazio C, Amato G, Lazzeri A, Monterisi S, Miracco C, Coral S, Anichini A, Bock C, Nemc A, Oganesian A, Lowder J, Azab M, Fridman WH, Sautès-Fridman C, Trajanoski Z, Maio M. Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial. Clin Cancer Res. 2019;25(24):7351–7362. doi:10.1158/1078-0432.CCR-19-1335
Abstract: https://pubmed.ncbi.nlm.nih.gov/31530631/

Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW; GLASS Consortium. Barthel FP, Johnson KC, Varn FS, et al. Longitudinal molecular trajectories of diffuse glioma in adults. Nature. 2019;576(7785):112–120. doi:10.1038/s41586-019-1775-1
Abstract: https://pubmed.ncbi.nlm.nih.gov/31748746/

Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells. Cell Rep. 2019;29(13):4447–4459.e6. doi:10.1016/j.celrep.2019.11.089
Abstract: https://pubmed.ncbi.nlm.nih.gov/31875552/

Rendeiro AF, Krausgruber T, Fortelny N, Zhao F, Penz T, Farlik M, Schuster LC, Nemc A, Tasnády S, Réti M, Mátrai Z, Alpár D, Bödör C, Schmidl C, Bock C. Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL. Nat Commun. 2020 Jan 29;11(1):577. doi: 10.1038/s41467-019-14081-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31996669

van Mierlo G, Dirks RAM, De Clerck L, Brinkman AB, Huth M, Kloet SL, Saksouk N, Kroeze LI, Willems S, Farlik M, Bock C, Jansen JH, Deforce D, Vermeulen M,Déjardin J, Dhaenens M, Marks H. Integrative Proteomic Profiling RevealsPRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. CellStem Cell. 2019 Jan 3;24(1):123-137.e8. doi: 10.1016/j.stem.2018.10.017. Epub2018 Nov 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30472157

Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L,Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML,Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L,Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019 Jun 7;364(6444). pii: eaas9536. doi:10.1126/science.aas9536.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31171666

Singh DD, Hawkins RD, Lahesmaa R, Tripathi SK. CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases. Semin Cell Dev Biol. 2019 Jun 19. pii: S1084-9521(18)30111-3. doi:10.1016/j.semcdb.2019.05.007. [Epub ahead of print] Review.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31112800

Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019 Mar 15;202(6):1724-1734. doi: 10.4049/jimmunol.1701649.Epub 2019 Feb 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30718299

Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G,Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P,Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL,Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, MechtlerK, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J,Kubicek S. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 2019 Jun;51(6):990-998. doi:10.1038/s41588-019-0413-z. Epub 2019 May 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133746

Schmidl C, Vladimer GI, Rendeiro AF, Schnabl S, Krausgruber T, Taubert C,Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K,Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, HoermannG, Kubicek S, Staber PB, Shehata M, Superti-Furga G, Jäger U, Bock C. Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL. Nat Chem Biol. 2019 Mar;15(3):232-240. doi: 10.1038/s41589-018-0205-2. Epub 2019 Jan 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30692684

Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E,Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D,Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A,Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. Blood. 2019 Jul 11;134(2):199-210. doi: 10.1182/blood.2019000519. Epub2019 May 7.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31064751

Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M,Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N,Boilard E, Binder CJ. Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells. Circ Res. 2019 Jun 21;125(1):43-52. doi:10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31219742

Müller F, Scherer M, Assenov Y, Lutsik P, Walter J, Lengauer T, Bock C. RnBeads 2.0: comprehensive analysis of DNA methylation data. Genome Biol. 2019Mar 14;20(1):55. doi: 10.1186/s13059-019-1664-9.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30871603

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P,Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H,de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease. Cancer Cell. 2019Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30645971

Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK. Colocalization analysesof genomic elements: approaches, recommendations and challenges. Bioinformatics. 2019 May 1;35(9):1615-1624. doi: 10.1093/bioinformatics/bty835. PubMed PMID:30307532;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6499241

Hamdane N, Jühling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, BandieraS, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I,Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoël M,Piardi T, Sommacale D, Imamura M, Uchida T, Ohdan H, Aikata H, Chayama K,Boldanova T, Pessaux P, Fuchs BC, Hoshida Y, Zeisel MB, Duong FHT, Baumert TF. HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response. Gastroenterology. 2019 Jun;156(8):2313-2329.e7.doi: 10.1053/j.gastro.2019.02.038. Epub 2019 Mar 2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30836093

Gruber M, Bozic I, Leshchiner I, Livitz D, Stevenson K, Rassenti L, RosebrockD, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, BrownJR, Neuberg D, Kipps TJ, Nowak MA, Getz G, Wu CJ. Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019 Jun;570(7762):474-479.doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31142838

Klughammer J, Kiesel B, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, Nowosielski M, Augustin M, Mischkulnig M, Ströbel T, Alpar D, Ergüner B, Senekowitsch M, Moser P, Freyschlag CF, Kerschbaumer J, Thomé C, Grams AE, Stockhammer G, Kitzwoegerer M, Oberndorfer S, Marhold F, Weis S, Trenkler J, Buchroithner J, Pichler J, Haybaeck J, Krassnig S, Mahdy Ali K, von Campe G, Payer F, Sherif C, Preiser J, Hauser T, Winkler PA, Kleindienst W, Würtz F, Brandner-Kokalj T, Stultschnig M, Schweiger S, Dieckmann K, Preusser M, Langs G, Baumann B, Knosp E, Widhalm G, Marosi C, Hainfellner JA, Woehrer A, Bock C. The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space. Nat Med. 2018 Oct;24(10):1611-1624. doi: 10.1038/s41591-018-0156-x. Epub 2018 Aug 27.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30150718

Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK. Colocalization analyses of genomic elements: approaches, recommendations and challenges. Bioinformatics. 2018 Oct 11. doi: 10.1093/bioinformatics/bty835. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30307532

Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, Sexl V, Bock C, Baccarini M. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018 Jun 1;22(6):879-892.e6. doi: 10.1016/j.stem.2018.05.003. Epub 2018 May 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29804890

Barakat TS, Halbritter F, Zhang M, Rendeiro AF, Perenthaler E, Bock C, Chambers I. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Cell Stem Cell. 2018 Aug 2;23(2):276-288.e8. doi: 10.1016/j.stem.2018.06.014. Epub 2018 Jul 19.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30033119

Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun. 2018 Jan;86:51-61. doi: 10.1016/j.jaut.2017.09.008. Epub 2017 Sep 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28964722

Pham HTT, Maurer B, Prchal-Murphy M, Grausenburger R, Grundschober E, Javaheri T, Nivarthi H, Boersma A, Kolbe T, Elabd M, Halbritter F, Pencik J, Kazemi Z, Grebien F, Hengstschläger M, Kenner L, Kubicek S, Farlik M, Bock C, Valent P, Müller M, Rülicke T, Sexl V, Moriggl R. STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest. 2018 Jan 2;128(1):387-401. doi: 10.1172/JCI94509. Epub 2017 Dec 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29200404

Aldape K, Amin SB, Ashley DM, Barnholtz-Sloan JS, Bates AJ, Beroukhim R, Bock C, Brat DJ, Claus EB, Costello JF, de Groot JF, Finocchiaro G, French PJ, Gan HK, Griffith B, Herold-Mende CC, Horbinski C, Iavarone A, Kalkanis SN, Karabatsou K, Kim H, Kouwenhoven MCM, McDonald KL, Miletic H, Nam DH, Ng HK, Niclou SP, Noushmehr H, Ormond R, Poisson LM, Reifenberger G, Roncaroli F, Sa JK, Sillevis Smitt PAE, Smits M, Souza CF, Tabatabai G, Van Meir EG, Verhaak RGW, Watts C, Wesseling P, Woehrer A, Yung WKA, Jungk C, Hau AC, van Dyck E, Westerman BA, Yin J, Abiola O, Zeps N, Grimmond S, Buckland M, Khasraw M, Sulman EP, Muscat AM, Stead L; GLASS Consortium. Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium. Neuro Oncol. 2018 Feb 8. doi: 10.1093/neuonc/noy020. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29432615

Skjærven KH, Jakt LM, Fernandes JMO, Dahl JA, Adam AC, Klughammer J, Bock C, Espe M. Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring. Sci Rep. 2018 Feb 14;8(1):3055. doi: 10.1038/s41598-018-21211-5.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29445184

Lowe R, Barton C, Jenkins CA, Ernst C, Forman O, Fernandez-Twinn DS, Bock C, Rossiter SJ, Faulkes CG, Ozanne SE, Walter L, Odom DT, Mellersh C, Rakyan VK. Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species. Genome Biol. 2018 Feb 16;19(1):22. doi: 10.1186/s13059-018-1397-1.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29452591

Lawson JT, Tomazou EM, Bock C, Sheffield NC. MIRA: An R package for DNA methylation-based inference of regulatory activity. Bioinformatics. 2018 Mar 1. doi: 10.1093/bioinformatics/bty083. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29506020

Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, Sexl V, Bock C, Baccarini M. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018 Jun 1;22(6):879-892.e6. doi: 10.1016/j.stem.2018.05.003. Epub 2018 May 24.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29804890

Simovski B, Kanduri C, Gundersen S, Titov D, Domanska D, Bock C, Bossini-Castillo L, Chikina M, Favorov A, Layer RM, Mironov AA, Quinlan AR, Sheffield NC, Trynka G, Sandve GK. Coloc-stats: a unified web interface to perform colocalization analysis of genomic features. Nucleic Acids Res. 2018 Jun 5. doi: 10.1093/nar/gky474. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29873782

Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V. CDK6 antagonizes p53-induced responses during tumorigenesis. Cancer Discov. 2018 Jun 13. pii: CD-17-0912. doi: 10.1158/2159-8290.CD-17-0912. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29899063

Vesely C, Frech C, Eckert C, Cario G, Mecklenbräuker A, Zur Stadt U, Nebral K, Kraler F, Fischer S, Attarbaschi A, Schuster M, Bock C, Cavé H, von Stackelberg A, Schrappe M, Horstmann MA, Mann G, Haas OA, Panzer-Grümayer R. Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia. Leukemia. 2017 Jul;31(7):1491-1501. doi: 10.1038/leu.2016.365. Epub 2016 Nov 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27899802

Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017 Apr;65(4):1181-1195. doi: 10.1002/hep.28970. Epub 2017 Feb 3.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27981604

Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat Neurosci. 2017 Feb;20(2):176-188. doi: 10.1038/nn.4462. Epub 2016 Dec 19.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27991900

Klughammer J, Dittrich M, Blom J, Mitesser V, Vogel U, Frosch M, Goesmann A, Müller T, Schoen C. Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease. PLoS One. 2017 Jan 12;12(1):e0169892. doi: 10.1371/journal.pone.0169892. eCollection 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28081260

Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C. Pooled CRISPR screening with single-cell transcriptome readout. Nat Methods. 2017 Mar;14(3):297-301. doi: 10.1038/nmeth.4177. Epub 2017 Jan 18.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28099430

Sheffield NC, Pierron G, Klughammer J, Datlinger P, Schönegger A, Schuster M, Hadler J, Surdez D, Guillemot D, Lapouble E, Freneaux P, Champigneulle J, Bouvier R, Walder D, Ambros IM, Hutter C, Sorz E, Amaral AT, de Álava E, Schallmoser K, Strunk D, Rinner B, Liegl-Atzwanger B, Huppertz B, Leithner A, de Pinieux G, Terrier P, Laurence V, Michon J, Ladenstein R, Holter W, Windhager R, Dirksen U, Ambros PF, Delattre O, Kovar H, Bock C, Tomazou EM. DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nat Med. 2017 Mar;23(3):386-395. doi: 10.1038/nm.4273. Epub 2017 Jan 30.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28134926

Albrecht F, List M, Bock C, Lengauer T. DeepBlueR: large-scale epigenomic analysis in R. Bioinformatics. 2017 Jul 1;33(13):2063-2064. doi: 10.1093/bioinformatics/btx099.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28334349

Maurer B, Farlik M, Sexl V. It is a differentiation game: STAT5 in a new role. Cell Death Differ. 2017 Jun;24(6):953-954. doi: 10.1038/cdd.2017.71. Epub 2017 May 12. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28498368

Müller H, Jimenez-Heredia R, Krolo A, Hirschmugl T, Dmytrus J, Boztug K, Bock C. VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data. Nucleic Acids Res. 2017 May 17. doi: 10.1093/nar/gkx425. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28520890

Licciardello MP, Ringler A, Markt P, Klepsch F, Lardeau CH, Sdelci S, Schirghuber E, Müller AC, Caldera M, Wagner A, Herzog R, Penz T, Schuster M, Boidol B, Dürnberger G, Folkvaljon Y, Stattin P, Ivanov V, Colinge J, Bock C, Kratochwill K, Menche J, Bennett KL, Kubicek S. A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor. Nat Chem Biol. 2017 Jul;13(7):771-778. doi: 10.1038/nchembio.2382. Epub 2017 May 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28530711

Fogg CN, Kovats DE, Berger B. 2017 ISCB Overton Prize: Christoph Bock. F1000Res. 2017 Jun 26;6. pii: ISCB Comm J-999. doi: 10.12688/f1000research.11586.1. eCollection 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28713546

Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, Mayer D, Kulinski TM, Theussl HC, Penninger JM, Bock C, Barlow DP, Pauler FM, Hudson QJ. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 2017 Aug 14;6. pii: e25125. doi: 10.7554/eLife.25125.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28806168

Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J Autoimmun. 2017 Sep 27. pii: S0896-8411(17)30595-4. doi: 10.1016/j.jaut.2017.09.008. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28964722

Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29089570

Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, and Kubicek S. Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity, Cell 2017 Jan 12 (epub ahead of print 2016 Dec 1);168(1), 86-100. doi:10.1016/j.cell.2016.11.010.Abstract: http://www.cell.com/cell/abstract/S0092-8674(16)31531-8

Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O. The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget. 2016 Feb 23;7(8):8613-24. doi: 10.18632/oncotarget.6937. Review.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890991/

Jeurissen ML, Walenbergh SM, Houben T, Gijbels MJ, Li J, Hendrikx T, Oligschlaeger Y, van Gorp PJ, Binder CJ, Donners MM, Shiri-Sverdlov R. Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice. Atherosclerosis. 2016 Oct 20;255:59-65. doi: 10.1016/j.atherosclerosis.2016.10.038
Abstract: http://www.atherosclerosis-journal.com/article/S0021-9150(16)31441-1/abstract

Ilott NE, Bollrath J, Danne C, Schiering C, Shale M, Adelmann K, Krausgruber T, Heger A, Sims D, Powrie F. Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling. ISME J. 2016 Oct;10(10):2389-404. doi: 10.1038/ismej.2016.40.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030693/

Farlik M, Halbritter F, Müller F, Choudry FA, Ebert P, Klughammer J, Farrow S, Santoro A, Ciaurro V, Mathur A, Uppal R, Stunnenberg HG, Ouwehand WH, Laurenti E, Lengauer T, Frontini M, Bock C. DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation. Cell Stem Cell. 2016 Dec 1;19(6):808-822. doi: 10.1016/j.stem.2016.10.019.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145815/

Bock C. Preserve personal freedom in networked societies. Nature. Commentary. 2016 Aug 31;537(7618):9. doi: 10.1038/537009a.
Abstract: http://www.nature.com/news/preserve-personal-freedom-in-networked-societies-1.20510

Aken BL, Ayling S, Barrell D, Clarke L, Curwen V, Fairley S, Fernandez Banet J, Billis K, García Girón C, Hourlier T, Howe K, Kähäri A, Kokocinski F, Martin FJ, Murphy DN, Nag R, Ruffier M, Schuster M, Tang YA, Vogel JH, White S, Zadissa A, Flicek P, Searle SM. The Ensembl gene annotation system. Database (Oxford). 2016 Jun 23;2016. pii: baw093. doi: 10.1093/database/baw093.
Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919035/

Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat Chem Biol. 2016 May 9. doi: 10.1038/nchembio.2080.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27159579

Rendeiro AF, Schmidl C, Strefford JC, Walewska R, Davis Z, Farlik M, Oscier D, Bock C. Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks. Nat Commun. 2016 Jun 27;7:11938. doi: 10.1038/ncomms11938.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27346425

Mass E, Ballesteros I, Farlik M, Halbritter F, Günther P, Crozet L, Jacome-Galarza CE, Händler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M, Bock C, Geissmann F. Specification of tissue-resident macrophages during organogenesis. Science. 2016 Aug 4. pii: aaf4238.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27492475

Martínez-Cardús A, Moran S, Musulen E, Moutinho C, Manzano JL, Martinez-Balibrea E, Tierno M, Élez E, Landolfi S, Lorden P, Arribas C, Müller F, Bock C, Tabernero J, Esteller M. Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-free and Overall Survival Times for Patients With Loco-regional Cancer. Gastroenterology. 2016 Aug 10. doi: 10.1053/j.gastro.2016.08.001.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27521480

Heller G, Topakian T, Altenberger C, Cerny-Reiterer S, Herndlhofer S, Ziegler B, Datlinger P, Byrgazov K, Bock C, Mannhalter C, Hörmann G, Sperr WR, Lion T, Zielinski CC, Valent P, Zöchbauer-Müller S. Next generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia. Leukemia. 2016 May 23. doi: 10.1038/leu.2016.143.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27211271

Gapp BV, Konopka T, Penz T, Dalal V, Bürckstümmer T, Bock C, Nijman SM. Parallel reverse genetic screening in mutant human cells using transcriptomics. Mol Syst Biol. 2016 Aug 1;12(8):879. doi: 10.15252/msb.20166890.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27482057

Feichtinger J, Hernández I, Fischer C, Hanscho M, Auer N, Hackl M, Jadhav V, Baumann M, Krempl PM, Schmidl C, Farlik M, Schuster M, Merkel A, Sommer A, Heath S, Rico D, Bock C, Thallinger GG, Borth N. Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time. Biotechnol Bioeng. 2016 Apr 12. doi: 10.1002/bit.25990.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27072894

Bock C, Farlik M, Sheffield NC. Multi-Omics of Single Cells: Strategies and Applications. Trends Biotechnol. 2016 Aug;34(8):605-8. doi: 10.1016/j.tibtech.2016.04.004.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/27212022

Assenov Y, Müller F, Lutsik P, Walter J, Lengauer T, Bock C. Comprehensive analysis of DNA methylation data with RnBeads. Nature Methods 11, 1138–1140 (2014) doi:10.1038/nmeth.3115.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25262207

Sheffield NC, Bock C. LOLA: Enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor. Bioinformatics. 2015 Oct 27. pii: btv612.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26508757

Schmidl C, Rendeiro AF, Sheffield NC, Bock C. ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors. Nat Methods. 2015 Aug 17. doi: 10.1038/nmeth.3542.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26280331

Milosevic Feenstra JD, Nivarthi H, Gisslinger H, Leroy E, Rumi E, Chachoua I, Bagienski K, Kubesova B, Pietra D, Gisslinger B, Milanesi C, Jäger R, Chen D, Berg T, Schalling M, Schuster M, Bock C, Constantinescu SN, Cazzola M, Kralovics R. Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms. Blood. 2015 Sep 30. pii: blood-2015-07-661835.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26423830

Licciardello MP, Müllner MK, Dürnberger G, Kerzendorfer C, Boidol B, Trefzer C, Sdelci S, Berg T, Penz T, Schuster M, Bock C, Kralovics R, Superti-Furga G, Colinge J, Nijman SM, Kubicek S. NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25263445

Li J, Klughammer J, Farlik M, Penz T, Spittler A, Barbieux C, Berishvili E, Bock C, Kubicek S. Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types. EMBO Rep. 2016 Feb. Epub 2015 Dec 21.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26691212

Klughammer J, Datlinger P, Printz D, Sheffield NC, Farlik M, Hadler J, Fritsch G, Bock C. Differential DNA Methylation Analysis without a Reference Genome. Cell Rep. 2015 Dec 7. pii: S2211-1247(15)01324-8. doi: 10.1016/j.celrep.2015.11.024.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26673328

Andergassen D, Dotter CP, Kulinski TM, Guenzl PM, Bammer PC, Barlow DP, Pauler FM, Hudson QJ. Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput sequencing data. Nucleic Acids Res. 2015 Dec 2;43(21):e146. doi: 10.1093/nar/gkv727. Epub 2015 Jul 21.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26202974

Tomazou EM, Sheffield NC, Schmidl C, Schuster M, Schönegger A, Datlinger P, Kubicek S, Bock C, Kovar H. Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1. Cell Rep. 2015 Feb 24;10(7):1082-95. doi: 10.1016/j.celrep.2015.01.042. Epub 2015 Feb 19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25704812

Malinowska-Ozdowy K, Frech C, Schönegger A, Eckert C, Cazzaniga G, Stanulla M, Zur Stadt U, Mecklenbräuker A, Schuster M, Kneidinger D, von Stackelberg A, Locatelli F, Schrappe M, Horstmann MA, Attarbaschi A, Bock C, Mann G, Haas OA, Panzer-Grümayer R. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Leukemia. 2015 Apr 28. doi: 10.1038/leu.2015.107.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25917266

Kulinski TM, Casari MR, Guenzl PM, Wenzel D, Andergassen D, Hladik A, Datlinger P, Farlik M, Theussl HC, Penninger JM, Knapp S, Bock C, Barlow DP, Hudson QJ. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305. doi: 10.1016/j.ydbio.2015.04.010. Epub 2015 Apr 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25912690

Farlik M, Sheffield NC, Nuzzo A, Datlinger P, Schönegger A, Klughammer J, Bock C. Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics. Cell Rep. 2015 Mar 3;10(8):1386-97. doi: 10.1016/j.celrep.2015.02.001. Epub 2015 Feb 26.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25732828

Ebert P, Bock C. Improving reference epigenome catalogs by computational prediction. Nat Biotechnol. 2015 Apr;33(4):354-5. doi: 10.1038/nbt.3194.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25850057

Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22;6:7091. doi: 10.1038/ncomms8091.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25997600

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F. Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a. Cell Rep. 2014 Aug 7;8(3):743-53. doi: 10.1016/j.celrep.2014.06.048. Epub 2014 Jul 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25066127

Bock C. Synergy and competition between cancer genome sequencing and epigenome mapping projects. Genome Med. 2014 May 30;6(5):41. doi: 10.1186/gm557. eCollection 2014.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25031623

Becker D, Lutsik P, Ebert P, Bock C, Lengauer T, Walter J. BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives. Nucleic Acids Res. 2014 Jul;42(Web Server issue):W501-7. doi: 10.1093/nar/gku457. Epub 2014 May 29.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24875479

Almouzni G, Altucci L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S, Bressac-de Paillerets B, Bussemakers M, Clarke L, Conesa A, Estivill X, Fazeli A, Grgurević N, Gut I, Heijmans BT, Hermouet S, Houwing-Duistermaat J, Iacobucci I, Ilaš J, Kandimalla R, Krauss-Etschmann S, Lasko P, Lehmann S, Lindroth A, Majdič G, Marcotte E, Martinelli G, Martinet N, Meyer E, Miceli C, Mills K, Moreno-Villanueva M, Morvan G, Nickel D, Niesler B, Nowacki M, Nowak J, Ossowski S, Pelizzola M, Pochet R, Potočnik U, Radwanska M, Raes J, Rattray M, Robinson MD, Roelen B, Sauer S, Schinzer D, Slagboom E, Spector T, Stunnenberg HG, Tiligada E, Torres-Padilla ME, Tsonaka R, Van Soom A, Vidaković M, Widschwendter M. Relationship between genome and epigenome--challenges and requirements for future research. BMC Genomics. 2014 Jun 18;15:487. doi: 10.1186/1471-2164-15-487.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24942464

Sanchez-Mut JV, Aso E, Heyn H, Matsuda T, Bock C, Ferrer I, Esteller M. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. 2014 Apr;24(4):363-8. doi: 10.1002/hipo.22245. Epub 2014 Jan 28.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24436131

Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods. 2013 Oct;10(10):965-71.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24161985

Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C, Irizarry RA. Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods. 2013 Oct;10(10):949-55. doi: 10.1038/nmeth.2632.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24076989

Vizcaíno JA, Côté RG, Csordas A, Dianes JA, Fabregat A, Foster JM, Griss J, Alpi E, Birim M, Contell J, O’Kelly J, Schoenegger A, Ovelleiro D, Pérez-Riverol Y, Reisinger F, Ríos D, Wang R, Hermjakob H. The Proteomics Identifications (PRIDE) database and associated tools: status in 2013. Nucleic Acids Res. 2013 January; 41(D1): D1063–D1069.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23203882

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer A-I, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller C, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V. A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell. 2013 August 12; 24(2): 167–181.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23948297

Cao K, Lailler N, Zhang Y, Kumar Y, Uppal K, Liu Z, Lee EK, Wu H, Medrzycki M, Pan C, Ho P-Y, Cooper GP Jr, Dong X, Bock C, Bouhassira EE, Fan Y. High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells. PLoS Genet. 2013 April; 9(4): e1003417.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23633960

Simmer F, Brinkman AB, Assenov Y, Matarese F, Kaan A, Sabatino L, Villanueva A, Huertas D, Esteller M, Lengauer T, Bock C, Colantuoni V, Altucci L, Stunnenberg HG. Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. Epigenetics. 2012 Dec 1;7(12):1355-67.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23079744

Mikeska T, Bock C, Do H, Dobrovic A. DNA methylation biomarkers in cancer: progress towards clinical implementation. Expert Review of Molecular Diagnostics. Expert Rev Mol Diagn. 2012 Jun;12(5):473-87.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22702364

Mekhoubad S, Bock C, Egli D, De Boer S, Kiskinis E, Meissner A, Eggan K. Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling. Cell Stem Cell 2012 May 4;10(5):595-609.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22560080

Halachev K, Bast H, Albrecht F, Lengauer T, Bock C. EpiExplorer: live exploration and global analysis of large epigenomic datasets. Genome Biol. 2012 Oct 3;13(10):R96.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23034089

Bock C. Analysing and interpreting DNA methylation data. Nat Rev Genet. 2012 Oct;13(10):705-19.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22986265

Bock C, Lengauer T. Managing drug resistance in cancer: lessons from HIV therapy. Nat Rev Cancer. 2012 Jun 7;12(7):494-501.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22673150

Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A. Genome-scale dynamics of DNA methylation during blood and skin stem cell differentiation. Mol Cell 2012 Aug 24;47(4):633-47.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22841485

Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Kuppers R, Lehrach H, Lengauer T, Lernmark A, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schubeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S. BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol 30, 224-226.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22398613