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Year
Paper
2023

Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Rebekka Lambrecht, Franziska Rudolf, Anna-Katharina Ückert, Valentina C Sladky, Truong San Phan, Jasmin Jansen, Samara Naim, Thomas Kaufmann, Adrian Keogh, Susanne Kirschnek, Aswin Mangerich, Florian Stengel, Marcel Leist, Andreas Villunger, Thomas Brunner.
Cell Death Differ. 2024 Jan;31(1):119-131. doi: 10.1038/s41418-023-01245-7. Epub 2023 Nov 24.
Abstract: https://pubmed.ncbi.nlm.nih.gov/38001256/
2023

Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance

Irmina Garcia-Carpio, Vincent Z Braun, Elias S Weiler, Marina Leone, Sergio Niñerola, Angel Barco, Luca L Fava, Andreas Villunger.
EMBO J. 2023 Oct 16;42(20):e113510. doi: 10.15252/embj.2023113510. Epub 2023 Aug 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37530438/
2023

Cellular polyploidy in organ homeostasis and regeneration

Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P G Sluijter.
Protein Cell. 2023 Aug 1;14(8):560-578. doi: 10.1093/procel/pwac064.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37526344/
2023

Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Julian Petersen, Lukas Englmaier, Artem V Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, Igor Adameyko.
Nat Commun. 2023 Jun 15;14(1):3565. doi: 10.1038/s41467-023-39373-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37322005/
2023

Apoptotic cell death in disease-Current understanding of the NCCD 2023

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Rami I Aqeilan, Eli Arama, Eric H Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A Barlev, Jiri Bartek, Nicolas G Bazan, Christoph Becker, Francesca Bernassola, Mathieu J M Bertrand, Marco E Bianchi, Mikhail V Blagosklonny, J Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H Chen, Emily H Cheng, Jerry E Chipuk, John A Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R Cubillos-Ruiz, Peter E Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M Dawson, Valina L Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J Dixon, Brian D Dynlacht, Wafik S El-Deiry, John W Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J Garcia-Saez, Abhishek D Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R Green, Lloyd A Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J Marie Hardwick, Ygal Haupt, Sudan He, David M Heery, Michael O Hengartner, Claudio Hetz, David A Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L Kelly, Oliver Kepp, Adi Kimchi, Richard N Kitsis, Daniel J Klionsky, Ruth Kluck, Dmitri V Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N Lavrik, John J Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A Lipton, Richard A Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J Martin, Jean-Claude Martinou, Pier G Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A Miao, Ute M Moll, Cristina Muñoz-Pinedo, Daniel J Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M Penninger, Francesca Pentimalli, David M Pereira, Shazib Pervaiz, Marcus E Peter, Paolo Pinton, Giovanni Porta, Jochen H M Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Krishnaraj Rajalingam, Kodi S Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M P Rodrigues, Barak Rotblat, Carla V Rothlin, David C Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M Ryan, Kristopher A Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W G Tait, Daolin Tang, Nektarios Tavernarakis, Carol M Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G Vander Heiden, Jacqueline L Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K Voss, Karen H Vousden, Domagoj Vucic, Daniela Vuri, Erwin F Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi.
Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37100955/
2023

Apoptosis as a Barrier against CIN and Aneuploidy

Johannes G Weiss, Filip Gallob, Patricia Rieder, Andreas Villunger.
Cancers (Basel). 2022 Dec 21;15(1):30. doi: 10.3390/cancers15010030.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36612027/
2022

The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

Katharina Hutter, Thomas Rülicke, Tamas G Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog.
Front Immunol. 2022 Aug 25;13:967914. doi: 10.3389/fimmu.2022.967914. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36110849/
2022

The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

Katharina Hutter, Thomas Rülicke, Tamas G Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog.
Front Immunol. 2022 Aug 25;13:967914. doi: 10.3389/fimmu.2022.967914. eCollection 2022.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36110849/
2022

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Ju Youn Kim, Lily Q Wang, Valentina C Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D Jacotot, Ronald M Evans, Andreas Villunger, Michael Karin.
Cell Metab. 2022 Oct 4;34(10):1548-1560.e6. doi: 10.1016/j.cmet.2022.08.005. Epub 2022 Aug 29.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36041455/
2022

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

Ju Youn Kim, Lily Q Wang, Valentina C Sladky, Tae Gyu Oh, Junlai Liu, Kaitlyn Trinh, Felix Eichin, Michael Downes, Mojgan Hosseini, Etienne D Jacotot, Ronald M Evans, Andreas Villunger, Michael Karin.
Cell Metab. 2022 Oct 4;34(10):1548-1560.e6. doi: 10.1016/j.cmet.2022.08.005. Epub 2022 Aug 29.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36041455/
2022

The miR-26 family regulates early B cell development and transformation

Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog.
Life Sci Alliance. 2022 Apr 22;5(8):e202101303. doi: 10.26508/lsa.202101303. Print 2022 Aug.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35459737/
2022

The miR-26 family regulates early B cell development and transformation

Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog.
Life Sci Alliance. 2022 Apr 22;5(8):e202101303. doi: 10.26508/lsa.202101303. Print 2022 Aug.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35459737/
2022

PIDD1 in cell cycle control, sterile inflammation and cell death

Elias S Weiler, Tamas G Szabo, Irmina Garcia-Carpio, Andreas Villunger.
Biochem Soc Trans. 2022 Apr 29;50(2):813-824. doi: 10.1042/BST20211186.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35343572/
2022

PIDD1 in cell cycle control, sterile inflammation and cell death

Elias S Weiler, Tamas G Szabo, Irmina Garcia-Carpio, Andreas Villunger.
Biochem Soc Trans. 2022 Apr 29;50(2):813-824. doi: 10.1042/BST20211186.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35343572/
Year
Paper
2021
Rizzotto D, Englmaier L, Villunger A. At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity. Int J Mol Sci. 2021 Oct 8;22(19):10883. doi: 10.3390/ijms221910883.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34639222/
2021
Pezzè L, Meškytė EM, Forcato M, Pontalti S, Badowska KA, Rizzotto D, Skvortsova II, Bicciato S, Ciribilli Y. ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes. Cell Death Dis. 2021 Jul 27;12(8):742. doi: 10.1038/s41419-021-04005-y.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34315857/
2021
Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ. Correction: Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2021 Jul 23. doi: 10.1038/s41418-021-00831-x. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34302122/
2021
Sladky VC, Eichin F, Reiberger T, Villunger A. Polyploidy control in hepatic health and disease. J Hepatol. 2021 Nov;75(5):1177-1191. doi: 10.1016/j.jhep.2021.06.030. Epub 2021 Jul 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34228992/
2021
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S. Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. FEBS J. 2021 Mar;288(5):1533-1545. doi: 10.1111/febs.15493. Epub 2020 Aug 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32705746/
2021
Rizzotto D, Villunger A. P53 clears aneuploid cells by entosis. Cell Death Differ. 2021 Feb;28(2):818-820. doi: 10.1038/s41418-020-00659-x. Epub 2020 Nov 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33149274/
2021
Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A, Maffini S, Fava LL. Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. EMBO J. 2021 Feb 15;40(4):e104844. doi: 10.15252/embj.2020104844. Epub 2020 Dec 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33350486/
2021
Sheikh TI, Vasli N, Pastore S, Kharizi K, Harripaul R, Fattahi Z, Pande S, Naeem F, Hussain A, Mir A, Islam O, Girisha KM, Irfan M, Ayub M, Schwarzer C, Najmabadi H, Shukla A, Sladky VC, Braun VZ, Garcia-Carpio I, Villunger A, Vincent JB. Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability. Transl Psychiatry. 2021 Jan 5;11(1):1. doi: 10.1038/s41398-020-01158-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33414379/
2020
Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. Cell Death Differ. 2020 Aug;27(8):2297-2312. doi: 10.1038/s41418-020-0503-6. Epub 2020 Feb 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32015503/
2020
Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ. Drp1 modulates mitochondrial stress responses to mitotic arrest. Cell Death Differ. 2020 Sep;27(9):2620-2634. doi: 10.1038/s41418-020-0527-y. Epub 2020 Mar 19.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32203171/
2020
Sladky VC, Villunger A. Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation. Cell Death Differ. 2020 Jul;27(7):2037-2047. doi: 10.1038/s41418-020-0556-6. Epub 2020 May 15.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32415279/
2020
Connolly P, Garcia-Carpio I, Villunger A. Cell-Cycle Cross Talk with Caspases and Their Substrates. Cold Spring Harb Perspect Biol. 2020 Jun 1;12(6):a036475. doi: 10.1101/cshperspect.a036475.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31727679/
2020
Hutter K, Lohmüller M, Jukic A, Eichin F, Avci S, Labi V, Szabo TG, Hoser SM, Hüttenhofer A, Villunger A, Herzog S. SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts. Mol Cell. 2020 Jun 4;78(5):876-889.e6. doi: 10.1016/j.molcel.2020.05.011.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32502422/
2020
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S. Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. FEBS J. 2021 Mar;288(5):1533-1545. doi: 10.1111/febs.15493. Epub 2020 Aug 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32705746/
2020
Rizzotto D, Villunger A. P53 clears aneuploid cells by entosis. Cell Death Differ. 2021 Feb;28(2):818-820. doi: 10.1038/s41418-020-00659-x. Epub 2020 Nov 4.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33149274/
2020
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A. PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Rep. 2020 Dec 3;21(12):e50893. doi: 10.15252/embr.202050893. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33225610/
2020
Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A, Maffini S, Fava LL. Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. EMBO J. 2021 Feb 15;40(4):e104844. doi: 10.15252/embj.2020104844. Epub 2020 Dec 22.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33350486/
2020
Sladky VC, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, Szabo TG, Bongiovanni L, Westendorp B, Moreno E, van Liere EA, Bakker B, Spierings DCJ, Wardenaar R, Pereyra D, Starlinger P, Schultze S, Trauner M, Stojakovic T, Scharnagl H, Fava LL, Foijer F, de Bruin A, Villunger A. E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Dev Cell. 2020 Feb 10;52(3):335-349.e7. doi: 10.1016/j.devcel.2019.12.016. Epub 2020 Jan 23.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31983631
2019
Connolly P, Garcia-Carpio I, Villunger A. Cell-Cycle Cross Talk with Caspases and Their Substrates. Cold Spring Harb Perspect Biol. 2019 Nov 14. pii: a036475. doi: 10.1101/cshperspect.a036475.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31727679/
2019
Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A. Checkpoint kinase 1 is essential for fetal and adult hematopoiesis. EMBO Rep. 2019 Aug;20(8):e47026. doi: 10.15252/embr.201847026. Epub 2019 Jun 17.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31379128
2019
Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N,Villunger A, Labi V. CHK1 dosage in germinal center B cells controls humoral immunity. Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5. [Epubahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30894677
2019
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A,Rajewsky K, Labi V. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J. 2019 May 23. doi:10.1111/febs.14934. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31120187
2019
Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M,Reichardt HM, Villunger A, Tischner D, Wiegers GJ. Glucocorticoid Receptor-Deficient Foxp3(+) Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease. Front Immunol. 2019 Mar 18;10:472. doi:10.3389/fimmu.2019.00472. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30936873
2019
Asslaber D, Wacht N, Leisch M, Qi Y, Maeding N, Hufnagl C, Jansko B, Zaborsky N, Villunger A, Hartmann TN, Greil R, Egle A. BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation. Clin Cancer Res. 2019 Mar 15;25(6):1901-1912. doi:10.1158/1078-0432.CCR-18-1548. Epub 2018 Nov 28.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30487125