Publications

Year

Paper

2023

Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C Albrich, Christian R Kahlert, Alexander Zoufaly, Marianna T Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Manfred Kneilling, Antonio Cozzio, Oltin Pop, David Bomze, Andreas Bergthaler, Omar Hasan Ali, Judith Aberle, Lukas Flatz.
J Autoimmun. 2023 Oct 10;140:103118. doi: 10.1016/j.jaut.2023.103118. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37826919/

2023

You only waste twice: T cells in parasite-induced organ wasting
Felix Clemens Richter, Andreas Bergthaler.
Cell Rep. 2023 Aug 29;42(8):112829. doi: 10.1016/j.celrep.2023.112829. Epub 2023 Jul 24.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37490906/

2023

WAVES (Web-based tool for Analysis and Visualization of Environmental Samples)-a web application for visualization of wastewater pathogen sequencing results
Petr Triska, Fabian Amman, Lukas Endler, Andreas Bergthaler.
Bioinformatics. 2023 Apr 3;39(4):btad160. doi: 10.1093/bioinformatics/btad160.
Abstract: https://pubmed.ncbi.nlm.nih.gov/37018136/

2022

VirPool: model-based estimation of SARS-CoV-2 variant proportions in wastewater samples
Askar Gafurov, Andrej Baláž, Fabian Amman, Kristína Boršová, Viktória Čabanová, Boris Klempa, Andreas Bergthaler, Tomáš Vinař, Broňa Brejová.
BMC Bioinformatics. 2022 Dec 19;23(1):551. doi: 10.1186/s12859-022-05100-3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36536300/

2022

Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
Benedikt Rumpf, Benno Lickefett, Clemens Baumgartner, Victoria Kauer, Mario Karolyi, Erich Pawelka, Tamara Seitz, Marianna Traugott, Petr Triska, Andreas Bergthaler, Hermann Laferl, Christoph Wenisch, Alexander Zoufaly.
Wien Klin Wochenschr. 2022 Dec;134(23-24):850-855. doi: 10.1007/s00508-022-02084-1. Epub 2022 Sep 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36070027/

2022

Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
Benedikt Rumpf, Benno Lickefett, Clemens Baumgartner, Victoria Kauer, Mario Karolyi, Erich Pawelka, Tamara Seitz, Marianna Traugott, Petr Triska, Andreas Bergthaler, Hermann Laferl, Christoph Wenisch, Alexander Zoufaly.
Wien Klin Wochenschr. 2022 Sep 7:1-6. doi: 10.1007/s00508-022-02084-1. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36070027/

2022

Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale
Fabian Amman, Rudolf Markt, Lukas Endler, Sebastian Hupfauf, Benedikt Agerer, Anna Schedl, Lukas Richter, Melanie Zechmeister, Martin Bicher, Georg Heiler, Petr Triska, Matthew Thornton, Thomas Penz, Martin Senekowitsch, Jan Laine, Zsofia Keszei, Peter Klimek, Fabiana Nägele, Markus Mayr, Beatrice Daleiden, Martin Steinlechner, Harald Niederstätter, Petra Heidinger, Wolfgang Rauch, Christoph Scheffknecht, Gunther Vogl, Günther Weichlinger, Andreas Otto Wagner, Katarzyna Slipko, Amandine Masseron, Elena Radu, Franz Allerberger, Niki Popper, Christoph Bock, Daniela Schmid, Herbert Oberacher, Norbert Kreuzinger, Heribert Insam, Andreas Bergthaler.
Nat Biotechnol. 2022 Dec;40(12):1814-1822. doi: 10.1038/s41587-022-01387-y. Epub 2022 Jul 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35851376/

2022

Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale
Fabian Amman, Rudolf Markt, Lukas Endler, Sebastian Hupfauf, Benedikt Agerer, Anna Schedl, Lukas Richter, Melanie Zechmeister, Martin Bicher, Georg Heiler, Petr Triska, Matthew Thornton, Thomas Penz, Martin Senekowitsch, Jan Laine, Zsofia Keszei, Peter Klimek, Fabiana Nägele, Markus Mayr, Beatrice Daleiden, Martin Steinlechner, Harald Niederstätter, Petra Heidinger, Wolfgang Rauch, Christoph Scheffknecht, Gunther Vogl, Günther Weichlinger, Andreas Otto Wagner, Katarzyna Slipko, Amandine Masseron, Elena Radu, Franz Allerberger, Niki Popper, Christoph Bock, Daniela Schmid, Herbert Oberacher, Norbert Kreuzinger, Heribert Insam, Andreas Bergthaler.
Nat Biotechnol. 2022 Jul 18. doi: 10.1038/s41587-022-01387-y. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35851376/

2022

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila
Shamsi Emtenani, Elliot T Martin, Attila Gyoergy, Julia Bicher, Jakob-Wendelin Genger, Thomas Köcher, Maria Akhmanova, Mariana Guarda, Marko Roblek, Andreas Bergthaler, Thomas R Hurd, Prashanth Rangan, Daria E Siekhaus.
EMBO J. 2022 Jun 14;41(12):e109049. doi: 10.15252/embj.2021109049. Epub 2022 Mar 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35319107/

2022

Emergence of SARS-CoV-2 Alpha lineage and its correlation with quantitative wastewater-based epidemiology data
Elena Radu, Amandine Masseron, Fabian Amman, Anna Schedl, Benedikt Agerer, Lukas Endler, Thomas Penz, Christoph Bock, Andreas Bergthaler, Julia Vierheilig, Peter Hufnagl, Irina Korschineck, Jörg Krampe, Norbert Kreuzinger.
Water Res. 2022 May 15;215:118257. doi: 10.1016/j.watres.2022.118257. Epub 2022 Mar 6.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35303559/

2022

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik, Karin Lakovits, Felicitas Oberndorfer, Shane Jf Cronin, Anna Ohradanova-Repic, Gerald Wirnsberger, Benedikt Agerer, Lukas Endler, Tümay Capraz, Jan W Perthold, Domagoj Cikes, Rubina Koglgruber, Astrid Hagelkruys, Nuria Montserrat, Ali Mirazimi, Louis Boon, Hannes Stockinger, Andreas Bergthaler, Chris Oostenbrink, Josef M Penninger, Sylvia Knapp.
Elife. 2022 Jan 13;11:e74623. doi: 10.7554/eLife.74623.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35023830/

Year

Paper

2021

Buchta C, Camp JV, Jovanovic J, Chiba P, Puchhammer-Stöckl E, Mayerhofer M, Plicka H, Lercher A, Popa AM, Endler L, Bergthaler A, Huf W, Benka B, Delatour V, Müller MM, Griesmacher A, Aberle SW, Görzer I. The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria. Clin Chem Lab Med. 2021 Jun 30;59(10):1735-1744. doi: 10.1515/cclm-2021-0604. Print 2021 Sep 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34187131/

2021

Leber W, Lammel O, Redlberger-Fritz M, Mustafa-Korninger ME, Glehr RC, Camp J, Agerer B, Lercher A, Popa A, Genger JW, Penz T, Aberle S, Bock C, Bergthaler A, Stiasny K, Hochstrasser EM, Hoellinger C, Siebenhofer A, Griffiths C, Panovska-Griffiths J. Rapid, early and accurate SARS-CoV-2 detection using RT-qPCR in primary care: a prospective cohort study (REAP-1). BMJ Open. 2021 Aug 2;11(8):e045225. doi: 10.1136/bmjopen-2020-045225.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34341034/

2021

Nicholson MD, Endler L, Popa A, Genger JW, Bock C, Michor F, Bergthaler A. Response to comment on "Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2". Sci Transl Med. 2021 Oct 27;13(617):eabj3222. doi: 10.1126/scitranslmed.abj3222. Epub 2021 Oct 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34705522/

2021

Smyth M, Khamina K, Popa A, Gudipati V, Agerer B, Lercher A, Kosack L, Endler L, Baazim H, Viczenczova C, Huppa JB, Bergthaler A. Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus. Front Immunol. 2021 Jun 14;12:638485. doi: 10.3389/fimmu.2021.638485. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34194424/

2021

Demiroz D, Platanitis E, Bryant M, Fischer P, Prchal-Murphy M, Lercher A, Lassnig C, Baccarini M, Müller M, Bergthaler A, Sexl V, Dolezal M, Decker T. Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons. PLoS Pathog. 2021 Jul 8;17(7):e1009697. doi: 10.1371/journal.ppat.1009697. eCollection 2021 Jul.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34237114/

2021

Singh DD, Verma R, Tripathi SK, Sahu R, Trivedi P, Yadav DK. Breast Cancer Transcriptional Regulatory Network Reprogramming by using the CRISPR/Cas9 System: An Oncogenetics Perspective. Curr Top Med Chem. 2021;21(31):2800-2813. doi: 10.2174/1568026621666210902120754.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34477520/

2021

Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. 24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation. J Hepatol. 2021 Nov;75(5):1164-1176. doi: 10.1016/j.jhep.2021.06.036. Epub 2021 Jul 7.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34242699/

2021

Klein K, Witalisz-Siepracka A, Gotthardt D, Agerer B, Locker F, Grausenburger R, Knab VM, Bergthaler A, Sexl V. T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo. Front Immunol. 2021 Jun 24;12:650977. doi: 10.3389/fimmu.2021.650977. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34248938/

2021

Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nat Rev Immunol. 2021 Oct 4:1-13. doi: 10.1038/s41577-021-00624-w. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34608281/

2021

Agerer B, Lercher A, Bergthaler A. The serine's call: Suppressing interferon responses. Cell Metab. 2021 May 4;33(5):849-850. doi: 10.1016/j.cmet.2021.04.012.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33951468/

2021

Baazim H, Antonio-Herrera L, Bergthaler A. The interplay of immunology and cachexia in infection and cancer. Nat Rev Immunol. 2021 Oct 4;1-13. doi: 10.1038/s41577-021-00624-w.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34608281/ _blank

2021

Buchta C, Camp JV, Jovanovic J, Chiba P, Puchhammer-Stöckl E, Mayerhofer M, Plicka H, Lercher A, Popa AM, Endler L, Bergthaler A, Huf W, Benka B, Delatour V, Müller MM, Griesmacher A, Aberle SW, Görzer I. The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria. Clin Chem Lab Med. 2021 Jun 29. DOI: 10.1515/cclm-2021-0604. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34187131/ _blank

2021

Unterluggauer L, Pospischil I, Krall C, Saluzzo S, Kimeswenger S, Karolyi M, Wenisch C, Lamprecht B, Guenova E, Winkler S, Viczenczova C, Bergthaler A, Weninger W, Hoetzenecker W, Stary G. Cutaneous manifestations of SARS-CoV-2: A 2-center, prospective, case-controlled study. J Am Acad Dermatol. 2021 Jul;85(1):202-204. doi: 10.1016/j.jaad.2021.03.064. Epub 2021 Mar 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33771589/ _blank

2021

Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM. A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. J Exp Med. 2021 Jan 4;218(1):e20200559. doi: 10.1084/jem.20200559.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32930709/

2021

Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8(+) T cell responses. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33664060/

2021

Gülich AF, Rica R, Tizian C, Viczenczova C, Khamina K, Faux T, Hainberger D, Penz T, Bosselut R, Bock C, Laiho A, Elo LL, Bergthaler A, Ellmeier W, Sakaguchi S. Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. Front Immunol. 2021 Mar 17;12:535039. doi: 10.3389/fimmu.2021.535039. eCollection 2021.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33815354/

2021

Unterluggauer L, Pospischil I, Krall C, Saluzzo S, Kimeswenger S, Karolyi M, Wenisch C, Lamprecht B, Guenova E, Winkler S, Viczenczova C, Bergthaler A, Weninger W, Hoetzenecker W, Stary G. Cutaneous manifestations of SARS-CoV-2: A 2-center, prospective, case-controlled study. J Am Acad Dermatol. 2021 Mar 23:S0190-9622(21)00619-8. doi: 10.1016/j.jaad.2021.03.064. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33771589/

2021

Xu HC, Wang R, Shinde PV, Walotka L, Huang A, Poschmann G, Huang J, Liu W, Stühler K, Schaal H, Bergthaler A, Pandyra AA, Hardt C, Lang KS, Lang PA. Slow viral propagation during initial phase of infection leads to viral persistence in mice. Commun Biol. 2021 Apr 29;4(1):508. doi: 10.1038/s42003-021-02028-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33927339/

2020

Jaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GE. Selective Mediator dependence of cell-type-specifying transcription. Nat Genet. 2020 Jul;52(7):719-727. doi: 10.1038/s41588-020-0635-0. Epub 2020 Jun 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32483291/

2020

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, Nemc A, Schmidl C, Rendeiro AF, Bergthaler A, Bock C. Structural cells are key regulators of organ-specific immune responses. Nature. 2020 Jul;583(7815):296-302. doi: 10.1038/s41586-020-2424-4. Epub 2020 Jul 1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32612232/

2020

Khou S, Popa A, Luci C, Bihl F, Meghraoui-Kheddar A, Bourdely P, Salavagione E, Cosson E, Rubod A, Cazareth J, Barbry P, Mari B, Rezzonico R, Anjuère F, Braud VM. Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development. Cancers (Basel). 2020 Jul 10;12(7):1860. doi: 10.3390/cancers12071860.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32664318/

2020

Keszei Z, Vendrell XM, Soultsioti M, Molina PR, Wirth L, Weiss H, Alexandridi M, Aloise C, Susma B, Guy C, Loverre A, Martinez SM, Mazej J, Spahn A, Sularea M, Hiscott J, Hoogen BVD. 100 days of solitude: The spring of COVID-19 through the eyes of 15 young virologists of the INITIATE program. Virus Res. 2020 Oct 2;287:198093. doi: 10.1016/j.virusres.2020.198093. Epub 2020 Jul 28.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32730780/

2020

van den Hoogen B, Santoni A, Sciumé G, Bowie A, O'Farrelly C, O'Neill L, Anthonsen M, Pardali K, Young S, Bergthaler A, Manel N, Zahn R, Kikkert M, Snijder E, van Kuppeveld F, Fouchier R, Hiscott J. Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska- Curie innovative training network. Virus Res. 2020 Oct 2;287:198094. doi: 10.1016/j.virusres.2020.198094. Epub 2020 Jul 28.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32730781/

2020

Kreidl P, Schmid D, Maritschnik S, Richter L, Borena W, Genger JW, Popa A, Penz T, Bock C, Bergthaler A, Allerberger F. Emergence of coronavirus disease 2019 (COVID-19) in Austria. Wien Klin Wochenschr. 2020 Nov;132(21-22):645-652. doi: 10.1007/s00508-020-01723-9. Epub 2020 Aug 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32816114/

2020

Zoufaly A, Poglitsch M, Aberle JH, Hoepler W, Seitz T, Traugott M, Grieb A, Pawelka E, Laferl H, Wenisch C, Neuhold S, Haider D, Stiasny K, Bergthaler A, Puchhammer-Stoeckl E, Mirazimi A, Montserrat N, Zhang H, Slutsky AS, Penninger JM. Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 2020 Nov;8(11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. Epub 2020 Sep 24. Erratum in: Lancet Respir Med. 2020 Nov;8(11):e78.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33131609/

2020

Lercher A, Popa AM, Viczenczova C, Kosack L, Klavins K, Agerer B, Opitz CA, Lanz TV, Platten M, Bergthaler A. Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis. PLoS Pathog. 2020 Oct 12;16(10):e1008973. doi: 10.1371/journal.ppat.1008973.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33045014/

2020

Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33199895/

2020

Popa A, Genger JW, Nicholson MD, Penz T, Schmid D, Aberle SW, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau ML, Martínez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A. Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2. Sci Transl Med. 2020 Dec 9;12(573):eabe2555. doi: 10.1126/scitranslmed.abe2555. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33229462/

2020

Girardi E, Agrimi G, Goldmann U, Fiume G, Lindinger S, Sedlyarov V, Srndic I, Gürtl B, Agerer B, Kartnig F, Scarcia P, Di Noia MA, Liñeiro E, Rebsamen M, Wiedmer T, Bergthaler A, Palmieri L, Superti-Furga G. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat Commun. 2020 Dec 1;11(1):6145. doi: 10.1038/s41467-020-19871-x.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33262325/

2020

Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Environmental arginine controls multinuclear giant cell metabolism and formation. Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31969567/

2020

Wilson JL, Nägele T, Linke M, Demel F, Fritsch SD, Mayr HK, Cai Z, Katholnig K, Sun X, Fragner L, Miller A, Haschemi A, Popa A, Bergthaler A, Hengstschläger M, Weichhart T, Weckwerth W. Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation. Cell Rep. 2020 Feb 4;30(5):1542-1552.e7. doi: 10.1016/j.celrep.2020.01.011.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32023468/

2020

van den Hoogen B, Santoni A, Sciumé G, Bowie A, O'Farrelly C, O'Neill L, Anthonsen M, Pardali K, Young S, Bergthaler A, Manel N, Zahn R, Kikkert M, Snijder E, van Kuppeveld F, Fouchier R, Hiscott J. Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network. Virus Res. 2020 Oct 2;287:198094. doi: 10.1016/j.virusres.2020.198094. Epub 2020 Jul 28.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32730781/

2020

Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole A, Pereyaslov D, WHO European Region sequencing laboratories and GISAID EpiCoV group; WHO European Region sequencing laboratories and GISAID EpiCoV group*. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Euro Surveill. 2020 Aug;25(32):2001410. doi: 10.2807/1560-7917.ES.2020.25.32.2001410.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32794443/

2020

Schrottmaier WC , Salzmann M, Badrnya S, Mussbacher M, Kral-Pointner JB, Morava S, Pirabe A, Brunnthaler L, Yaiw KC, Heber UM, Pereyra D, Andersen JT, Bergthaler A, Söderberg-Nauclér C, Karlsson MCI, Assinger A, Forsell MNE. Platelets mediate serological memory to neutralize viruses in vitro and in vivo. Blood Adv. 2020 Aug 25;4(16):3971-3976. doi: 10.1182/bloodadvances.2020001786.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32841338/

2020

Ali OH, Bomze D, Risch L, Brugger SD, Paprotny M, Weber M, Thiel S, Kern L, Albrich WC, Kohler P, Kahlert CR, Vernazza P, Bühler PK, Schüpbach RA, Gómez-Mejia A, Popa AM, Bergthaler A, Penninger JM, Flatz L. Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies. Clin Infect Dis. 2020 Sep 30;ciaa1496. doi: 10.1093/cid/ciaa1496. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32997739/

2020

Liu GJ, Jaritz M, Wöhner M, Agerer B, Bergthaler A, Malin SG, Busslinger M. Repression of the B cell identity factor Pax5 is not required for plasma cell development. J Exp Med. 2020 Nov 2;217(11):e20200147. doi: 10.1084/jem.20200147.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32780801/

2020

Lercher A, Baazim H, Bergthaler A. Systemic Immunometabolism: Challenges and Opportunities. Immunity. 2020 Sep 15;53(3):496-509. doi: 10.1016/j.immuni.2020.08.012.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32937151/

2020

2019

Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4. Epub 2019 May 27.
Abstract: https://pubmed.ncbi.nlm.nih.gov/31133695/

2019

Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A. Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function. Immunity. 2019;51(6):1074–1087.e9. doi:10.1016/j.immuni.2019.10.014
Abstract: https://pubmed.ncbi.nlm.nih.gov/31784108/

2019

Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T. Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. JCI Insight. 2019;4(20):e124164. Published 2019 Oct 17. doi:10.1172/jci.insight.124164
Abstract: https://pubmed.ncbi.nlm.nih.gov/31619583/

2019

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P,Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H,de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV,Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease. Cancer Cell. 2019Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30645971

2019

Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GA. A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52. Sci Rep. 2019 May 27;9(1):7901. doi:10.1038/s41598-019-44359-0.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31133683

2019

Goncalves-Alves E, Saferding V, Schliehe C, Benson R, Kurowska-Stolarska M,Brunner JS, Puchner A, Podesser BK, Smolen JS, Redlich K, Bonelli M, Brewer J, Bergthaler A, Steiner G, Blüml S. MicroRNA-155 Controls T Helper Cell Activation During Viral Infection. Front Immunol. 2019 Jun 13;10:1367. doi:10.3389/fimmu.2019.01367. eCollection 2019.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31275315

2019

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, AliA, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D,Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. CD8(+) T cells induce cachexia during chronic viral infection. Nat Immunol. 2019Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID:31110314;
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31110314.

2018

Benke S, Agerer B, Haas L, Stöger M, Lercher A, Gabler L, Kiss I, Scinicariello S, Berger W, Bergthaler A, Obenauf AC, Versteeg GA. Human tripartite motif protein 52 is required for cell context-dependent proliferation. Oncotarget. 2018 Feb 5;9(17):13565-13581. doi: 10.18632/oncotarget.24422. eCollection 2018 Mar 2.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29568378

2017

Khamina K , Lercher A , Caldera M, Schliehe C , Vilagos B , Sahin M, Kosack L, Bhattacharya A, Májek P, Stukalov A, Sacco R, James LC, Pinschewer DD, Bennett KL, Menche J, Bergthaler A. Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. PLoS Pathogens 13(12): e1006758; 2017.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29261807

2017

Bergthaler A, Menche J. The immune system as a social network. Nat Immunol. 2017 Apr 18;18(5):481-482. doi: 10.1038/ni.3727. No abstract available.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28418389

2017

Leite FGG, Bergthaler A, Skern T. Vaccinia virus G1 protein: absence of autocatalytic self-processing. Arch Virol. 2017 May 18. doi: 10.1007/s00705-017-3409-y. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28523522

2017

Hegazy AN, West NR, Stubbington MJT, Wendt E, Suijker KIM, Datsi A, This S, Danne C, Campion S, Duncan SH, Owens BMJ, Uhlig HH, McMichael A; Oxford IBD Cohort Investigators, Bergthaler A, Teichmann SA, Keshav S, Powrie F. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28782508

2017

Kosack L, Gawish R, Lercher A, Vilagos B, Hladik A, Lakovits K, Bhattacharya A, Schliehe C, Mesteri I, Knapp S, Bergthaler A. The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis. Sci Rep. 2017 Sep 12;7(1):11289. doi: 10.1038/s41598-017-10637-y.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28900132

2017

Saudemont B, Popa A, Parmley JL, Rocher V, Blugeon C, Necsulea A, Meyer E, Duret L. The fitness cost of mis-splicing is the main determinant of alternative splicing patterns. Genome Biol. 2017 Oct 30;18(1):208. doi: 10.1186/s13059-017-1344-6.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29084568

2016

Rothchild AC, Sissons JR, Shafiani S, Plaisier C, Min D, Mai D, Gilchrist M, Peschon J, Larson RP, Bergthaler A, Baliga NS, Urdahl KB, Aderem A. MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6172-E6181.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27681624

2016

Newman DM, Sakaguchi S, Lun A, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS. Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity. Cell Rep. 2016 Sep 20;16(12):3311-21. doi: 10.1016/j.celrep.2016.08.056.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27653692

2015

Schliehe, C., E.K. Flynn, B. Vilagos, U. Richson, S. Swaminathan, B. Bosnjak, L. Bauer, R.K. Kandasamy, I.M. Griesshammer, L. Kosack, F. Schmitz, V. Litvak, J. Sissons, A. Lercher, A. Bhattacharya, K. Khamina, A.L. Trivett, L. Tessarollo, I. Mesteri, A. Hladik, D. Merkler, S. Kubicek, S. Knapp, M.M. Epstein, D.E. Symer, A. Aderem, and A. Bergthaler, The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol, 2015. 16(1): p. 67-74.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25419628

2015

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M, Bergthaler A, Igonet S, Ter Meulen J, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD. Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. PLoS Pathog. 2015 Nov 20;11(11):e1005276. doi: 10.1371/journal.ppat.1005276. eCollection 2015 Nov.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26587982

2015

Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26588782

2015

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M, Bergthaler A, Igonet S, Ter Meulen J, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD. Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. PLoS Pathog. 2015 Nov 20;11(11):e1005276. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26587982

2015

Johnson S*, Bergthaler A*, Graw F, Flatz L, Bonilla WV, Siegrist CA, Lambert PH, Regoes RR, Pinschewer DD. Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection. J Immunol. 2015 Feb 15;194(4):1755-62. doi: 10.4049/jimmunol.1401771. Epub 2015 Jan 7. (* these authors contributed equally)
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25567678

2015

Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Schliehe C, Panse I, Vilagos B, Khamina K, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Superoxide dismutase 1 protects from type I interferon-driven oxidative damage in viral hepatitis. Immunity Volume 43, Issue 5, p974–986, 17 November 2015.
Abstract: http://www.cell.com/immunity/abstract/S1074-7613(15)00438-0

2014

Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nature Immunology. 2014 Nov 24.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25419628

2013

Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D. Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss. J Exp Med. 2013 Sep 23;210(10):2087-103. doi: 10.1084/jem.20122143. Epub 2013 Sep 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23999498

2012

Litvak V, Ratushny AV, Lampano AE, Schmitz F, Huang AC, Raman A, Rust AG, Bergthaler A, Aitchison JD, Aderem A. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature. 2012 Oct 18;490(7420):421-5.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22982991