Publications
2025
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation
Teresa Neuwirth,
Daniel Malzl,
Katja Knapp,
Panagiota Tsokkou,
Lisa Kleissl,
Anna Gabriel,
Baerbel Reininger,
Christian Freystätter,
Nara Marella,
Ana P Kutschat,
Elisabeth Ponweiser,
Arvand Haschemi,
Davide Seruggia,
Jörg Menche,
Erwin F Wagner,
Georg Stary.
Immunity. 2025 Mar 11;58(3):632-647.e12. doi: 10.1016/j.immuni.2025.02.011. Epub 2025 Feb 28.
2024
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6
Thibault Viennet,
Maolu Yin,
Abhilash Jayaraj,
Woojin Kim,
Zhen-Yu J Sun,
Yuko Fujiwara,
Kevin Zhang,
Davide Seruggia,
Hyuk-Soo Seo,
Sirano Dhe-Paganon,
Stuart H Orkin,
Haribabu Arthanari.
Structure. 2024 Dec 5;32(12):2276-2286.e4. doi: 10.1016/j.str.2024.09.022. Epub 2024 Oct 17.
2024
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing
Basheer Becerra,
Sandra Wittibschlager,
Zain M Patel,
Ana P Kutschat,
Justin Delano,
Eric Che,
Anzhelika Karjalainen,
Ting Wu,
Marlena Starrs,
Martin Jankowiak,
Daniel E Bauer,
Davide Seruggia,
Luca Pinello.
bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612085. doi: 10.1101/2024.09.09.612085.
2024
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
Cristiano De Sá Fernandes,
Philipp Novoszel,
Tommaso Gastaldi,
Dana Krauß,
Magdalena Lang,
Ramona Rica,
Ana P Kutschat,
Martin Holcmann,
Wilfried Ellmeier,
Davide Seruggia,
Herbert Strobl,
Maria Sibilia.
Cell Rep. 2024 Jun 25;43(6):114308. doi: 10.1016/j.celrep.2024.114308. Epub 2024 Jun 2.
2023
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche
Elisa Manieri,
Guodong Tie,
Ermanno Malagola,
Davide Seruggia,
Shariq Madha,
Adrianna Maglieri,
Kun Huang,
Yuko Fujiwara,
Kevin Zhang,
Stuart H Orkin,
Timothy C Wang,
Ruiyang He,
Neil McCarthy,
Ramesh A Shivdasani.
Nat Commun. 2023 Dec 2;14(1):7978. doi: 10.1038/s41467-023-43619-y.
2023
In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice
Bin E Li,
Grace Y Li,
Wenqing Cai,
Qian Zhu,
Davide Seruggia,
Yuko Fujiwara,
Christopher R Vakoc,
Stuart H Orkin.
Blood Adv. 2023 Sep 26;7(18):5281-5293. doi: 10.1182/bloodadvances.2022009455.
2022
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Stuti Mehta,
Altantsetseg Buyanbat,
Yan Kai,
Ozge Karayel,
Seth Raphael Goldman,
Davide Seruggia,
Kevin Zhang,
Yuko Fujiwara,
Katherine A Donovan,
Qian Zhu,
Huan Yang,
Behnam Nabet,
Nathanael S Gray,
Matthias Mann,
Eric S Fischer,
Karen Adelman,
Stuart H Orkin.
Cell Chem Biol. 2022 Aug 18;29(8):1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. Epub 2022 Jul 14.
2021
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.
Shahin T,
Kuehn HS,
Shoeb MR,
Gawriyski L,
Giuliani S,
Repiscak P,
Hoeger B,
Yüce Petronczki Ö,
Bal SK,
Zoghi S,
Dmytrus J,
Seruggia D,
Castanon I,
Rezaei N,
Varjosalo M,
Halbritter F,
Rosenzweig SD,
Boztug K.
Sci Immunol. 2021 Nov 26;6(65):eabe3981. doi: 10.1126/sciimmunol.abe3981. Epub 2021 Nov 26.
