Chemical probing and functional characterization of the E3 substrate receptor DCAF15
The targeted degradation of proteins is of utmost importance for the well-being of our cells and thus for the entire organism. Damaged proteins must be recognized and removed to prevent collateral damage. In addition, proteins must be removed in a targeted manner in order to allow the activation, but also the deactivation of cellular signal transduction pathways. Defects in the targeted degradation of proteins can result in diseases such as cancer and neurodegeneration.
The Special Research Program, SFB F79, is funded by the Austrian Science Fund (FWF) with contributions by the German Research Foundation (DFG).
The collaborative research program includes scientists from Max Perutz Labs, University of Vienna, Medical University of Vienna, CeMM, GMI, IMBA and IMP from Vienna as well as IMB in Mainz, who have joined forces to discover mechanism of targeted protein degradation, and how this process can be manipulated.