Publications
2022
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Cathrine Nordgaard,
Anna Constance Vind,
Amy Stonadge,
Rasmus Kjøbsted,
Goda Snieckute,
Pedro Antas,
Melanie Blasius,
Marie Sofie Reinert,
Ana Martinez Del Val,
Dorte Breinholdt Bekker-Jensen,
Peter Haahr,
Yekaterina A Miroshnikova,
Abdelghani Mazouzi,
Sarah Falk,
Emeline Perrier-Groult,
Christopher Tiedje,
Xiang Li,
Jens Rithamer Jakobsen,
Nicolas Oldenburg Jørgensen,
Jørgen Fp Wojtaszewski,
Frederic Mallein-Gerin,
Jesper Løvind Andersen,
Cristian Pablo Pennisi,
Christoffer Clemmensen,
Moustapha Kassem,
Abbas Jafari,
Thijn Brummelkamp,
Vivian Sw Li,
Sara A Wickström,
Jesper Velgaard Olsen,
Gonzalo Blanco,
Simon Bekker-Jensen.
EMBO J. 2022 Sep 1;41(17):e111650. doi: 10.15252/embj.2022111650. Epub 2022 Jul 28.
2021
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Jongsma MLM,
de Waard AA,
Raaben M,
Zhang T,
Cabukusta B,
Platzer R,
Blomen VA,
Xagara A,
Verkerk T,
Bliss S,
Kong X,
Gerke C,
Janssen L,
Stickel E,
Holst S,
Plomp R,
Mulder A,
Ferrone S,
Claas FHJ,
Heemskerk MHM,
Griffioen M,
Halenius A,
Overkleeft H,
Huppa JB,
Wuhrer M,
Brummelkamp TR,
Neefjes J,
Spaapen RM.
Immunity. 2021 Jan 12;54(1):132-150.e9. doi: 10.1016/j.immuni.2020.11.003. Epub 2020 Dec 2.
2020
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.
Sarbanes SL,
Blomen VA,
Lam E,
Heissel S,
Luna JM,
Brummelkamp TR,
Falck-Pedersen E,
Hoffmann HH,
Rice CM.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015794118. doi: 10.1073/pnas.2015794118. Epub 2020 Dec 21.
2020
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.
Jongsma MLM,
de Waard AA,
Raaben M,
Zhang T,
Cabukusta B,
Platzer R,
Blomen VA,
Xagara A,
Verkerk T,
Bliss S,
Kong X,
Gerke C,
Janssen L,
Stickel E,
Holst S,
Plomp R,
Mulder A,
Ferrone S,
Claas FHJ,
Heemskerk MHM,
Griffioen M,
Halenius A,
Overkleeft H,
Huppa JB,
Wuhrer M,
Brummelkamp TR,
Neefjes J,
Spaapen RM.
Immunity. 2021 Jan 12;54(1):132-150.e9. doi: 10.1016/j.immuni.2020.11.003. Epub 2020 Dec 2. Erratum in: Immunity. 2021 Feb 9;54(2):387.
2021
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.
Sarbanes SL,
Blomen VA,
Lam E,
Heissel S,
Luna JM,
Brummelkamp TR,
Falck-Pedersen E,
Hoffmann HH,
Rice CM.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015794118. doi: 10.1073/pnas.2015794118. Epub 2020 Dec 21.
2020
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Loregger A,
Raaben M,
Nieuwenhuis J,
Tan JME,
Jae LT,
van den Hengel LG,
Hendrix S,
van den Berg M,
Scheij S,
Song JY,
Huijbers IJ,
Kroese LJ,
Ottenhoff R,
van Weeghel M,
van de Sluis B,
Brummelkamp T,
Zelcer N.
Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1.
2020
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.
Surface LE,
Burrow DT,
Li J,
Park J,
Kumar S,
Lyu C,
Song N,
Yu Z,
Rajagopal A,
Bae Y,
Lee BH,
Mumm S,
Gu CC,
Baker JC,
Mohseni M,
Sum M,
Huskey M,
Duan S,
Bijanki VN,
Civitelli R,
Gardner MJ,
McAndrew CM,
Ricci WM,
Gurnett CA,
Diemer K,
Wan F,
Costantino CL,
Shannon KM,
Raje N,
Dodson TB,
Haber DA,
Carette JE,
Varadarajan M,
Brummelkamp TR,
Birsoy K,
Sabatini DM,
Haller G,
Peterson TR.
Sci Transl Med. 2020 May 20;12(544):eaav9166. doi: 10.1126/scitranslmed.aav9166.
2019
SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.
Mezzadra R,
de Bruijn M,
Jae LT,
Gomez-Eerland R,
Duursma A,
Scheeren FA,Brummelkamp TR,
Schumacher TN.
PLoS One. 2019 Feb 12;14(2):e0212053. doi:10.1371/journal.pone.0212053. eCollection 2019.
2019
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.
Heijink AM,
Talens F,
Jae LT,
van Gijn SE,
Fehrmann RSN,
Brummelkamp TR,
van Vugt MATM.
NatCommun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. PubMed PMID:30626869;
2019
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Adamopoulos A,
Landskron L,
Heidebrecht T,
Tsakou F,
Bleijerveld OB,
Altelaar M,
Nieuwenhuis J,
Celie PHN,
Brummelkamp TR,
Perrakis A.
Nat Struct Mol Biol. 2019 Jul;26(7):567-570. doi: 10.1038/s41594-019-0254-6. Epub 2019 Jul 1.
