Publications
2025
Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
Mariem Radhouani,
Asma Farhat,
Anna Hakobyan,
Sophie Zahalka,
Lisabeth Pimenov,
Alina Fokina,
Anastasiya Hladik,
Karin Lakovits,
Jessica Brösamlen,
Vojtech Dvorak,
Natalia Nunes,
Andreas Zech,
Marco Idzko,
Thomas Krausgruber,
Jörg Köhl,
Ozge Uluckan,
Jiri Kovarik,
Kai Hoehlig,
Axel Vater,
Margret Eckhard,
Andy Sombke,
Nikolaus Fortelny,
Jörg Menche,
Sylvia Knapp,
Philipp Starkl.
Sci Immunol. 2025 Apr 4;10(106):eadp6231. doi: 10.1126/sciimmunol.adp6231. Epub 2025 Apr 4.
2025
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Asma Farhat,
Mariem Radhouani,
Florian Deckert,
Sophie Zahalka,
Lisabeth Pimenov,
Alina Fokina,
Anna Hakobyan,
Felicitas Oberndorfer,
Jessica Brösamlen,
Anastasiya Hladik,
Karin Lakovits,
Fanzhe Meng,
Federica Quattrone,
Louis Boon,
Cornelia Vesely,
Philipp Starkl,
Nicole Boucheron,
Jörg Menche,
Joris van der Veeken,
Wilfried Ellmeier,
Anna-Dorothea Gorki,
Clarissa Campbell,
Riem Gawish,
Sylvia Knapp.
Sci Immunol. 2025 Mar 28;10(105):eadk5041. doi: 10.1126/sciimmunol.adk5041. Epub 2025 Mar 28.
2024
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Valentina Stolz,
Rafael de Freitas E Silva,
Ramona Rica,
Ci Zhu,
Teresa Preglej,
Patricia Hamminger,
Daniela Hainberger,
Marlis Alteneder,
Lena Müller,
Monika Waldherr,
Darina Waltenberger,
Anastasiya Hladik,
Benedikt Agerer,
Michael Schuster,
Tobias Frey,
Thomas Krausgruber,
Sylvia Knapp,
Clarissa Campbell,
Klaus Schmetterer,
Michael Trauner,
Andreas Bergthaler,
Christoph Bock,
Nicole Boucheron,
Wilfried Ellmeier.
Elife. 2024 Oct 28;13:e78738. doi: 10.7554/eLife.78738.
2024
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain
Philipp Starkl,
Gustav Jonsson,
Tyler Artner,
Bruna Lenfers Turnes,
Laura-Marie Gail,
Tiago Oliveira,
Aakanksha Jain,
Nadine Serhan,
Karel Stejskal,
Karin Lakovits,
Anastasiya Hladik,
Meilin An,
Keith M Channon,
Hail Kim,
Thomas Köcher,
Wolfgang Weninger,
Georg Stary,
Sylvia Knapp,
Victoria Klang,
Nicolas Gaudenzio,
Clifford J Woolf,
Shweta Tikoo,
Rohit Jain,
Josef M Penninger,
Shane J F Cronin.
Sci Immunol. 2024 Aug 23;9(98):eadh0545. doi: 10.1126/sciimmunol.adh0545. Epub 2024 Aug 23.
2024
Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma
Mariem Radhouani,
Philipp Starkl.
Front Allergy. 2024 Aug 2;5:1423938. doi: 10.3389/falgy.2024.1423938. eCollection 2024.
2022
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling
Sophie Zahalka,
Philipp Starkl,
Martin L Watzenboeck,
Asma Farhat,
Mariem Radhouani,
Florian Deckert,
Anastasiya Hladik,
Karin Lakovits,
Felicitas Oberndorfer,
Caroline Lassnig,
Birgit Strobl,
Kristaps Klavins,
Mai Matsushita,
David E Sanin,
Katarzyna M Grzes,
Edward J Pearce,
Anna-Dorothea Gorki,
Sylvia Knapp.
Mucosal Immunol. 2022 May;15(5):896-907. doi: 10.1038/s41385-022-00528-5. Epub 2022 Jul 18.
2021
Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters.
Grzes KM,
Sanin DE,
Kabat AM,
Stanczak MA,
Edwards-Hicks J,
Matsushita M,
Hackl A,
Hässler F,
Knoke K,
Zahalka S,
Villa M,
Kofler DM,
Voll RE,
Zigrino P,
Fabri M,
Pearce EL,
Pearce EJ.
Immunity. 2021 Nov 9;54(11):2514-2530.e7. doi: 10.1016/j.immuni.2021.10.009. Epub 2021 Oct 29.
2022
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
Riem Gawish,
Philipp Starkl,
Lisabeth Pimenov,
Anastasiya Hladik,
Karin Lakovits,
Felicitas Oberndorfer,
Shane Jf Cronin,
Anna Ohradanova-Repic,
Gerald Wirnsberger,
Benedikt Agerer,
Lukas Endler,
Tümay Capraz,
Jan W Perthold,
Domagoj Cikes,
Rubina Koglgruber,
Astrid Hagelkruys,
Nuria Montserrat,
Ali Mirazimi,
Louis Boon,
Hannes Stockinger,
Andreas Bergthaler,
Chris Oostenbrink,
Josef M Penninger,
Sylvia Knapp.
Elife. 2022 Jan 13;11:e74623. doi: 10.7554/eLife.74623.
2020
Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient.
Lang C,
Jaksch P,
Hoda MA,
Lang G,
Staudinger T,
Tschernko E,
Zapletal B,
Geleff S,
Prosch H,
Gawish R,
Knapp S,
Robak O,
Thalhammer F,
Indra A,
Koestenberger M,
Strassl R,
Klikovits T,
Ali K,
Fischer G,
Klepetko W,
Hoetzenecker K,
Schellongowski P.
Lancet Respir Med. 2020 Oct;8(10):1057-1060. doi: 10.1016/S2213-2600(20)30361-1. Epub 2020 Aug 25.
2020
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Esparza-Baquer A,
Labiano I,
Sharif O,
Agirre-Lizaso A,
Oakley F,
Rodrigues PM,
Zhuravleva E,
O'Rourke CJ,
Hijona E,
Jimenez-Agüero R,
Riaño I,
Landa A,
La Casta A,
Zaki MYW,
Munoz-Garrido P,
Azkargorta M,
Elortza F,
Vogel A,
Schabbauer G,
Aspichueta P,
Andersen JB,
Knapp S,
Mann DA,
Bujanda L,
Banales JM,
Perugorria MJ.
Gut. 2020 Sep 9:gutjnl-2019-319227. doi: 10.1136/gutjnl-2019-319227. Epub ahead of print.
