Publications
2017
Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.
Forment JV,
Herzog M,
Coates J,
Konopka T,
Gapp BV,
Nijman SM,
Adams DJ,
Keane TM,
Jackson SP.
Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31.
2013
A reversible gene trap collection empowers haploid genetics in human cells.
Bürckstümmer T,
Banning C,
Hainzl P,
Schobesberger R,
Kerzendorfer C,
Pauler FM,
Chen D,
Them N,
Schischlik F,
Rebsamen M,
Smida M,
Fece de la Cruz F,
Lapao A,
Liszt M,
Eizinger B,
Guenzl PM,
Blomen VA,
Konopka T,
Gapp B,
Parapatics K,
Maier B,
Stöckl J,
Fischl W,
Salic S,
Taba Casari MR,
Knapp S,
Bennett KL,
Bock C,
Colinge J,
Kralovics R,
Ammerer G,
Casari G,
Brummelkamp TR,
Superti-Furga G,
Nijman SM.
Nat Methods. 2013 Oct;10(10):965-71.
2016
Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.
Forment JV,
Herzog M,
Coates J,
Konopka T,
Gapp BV,
Nijman SM,
Adams DJ,
Keane TM,
Jackson SP.
Nat Chem Biol. 2016 Oct 31. doi: 10.1038/nchembio.2226.
2016
Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.
Mair B,
Konopka T,
Kerzendorfer C,
Sleiman K,
Salic S,
Serra V,
Muellner MK,
Theodorou V,
Nijman SM.
PLoS Genet. 2016 Sep 2;12(9):e1006279. doi: 10.1371/journal.pgen.1006279.
2016
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Smida M,
Fece de la Cruz F,
Kerzendorfer C,
Uras IZ,
Mair B,
Mazouzi A,
Suchankova T,
Konopka T,
Katz AM,
Paz K,
Nagy-Bojarszky K,
Muellner MK,
Bago-Horvath Z,
Haura EB,
Loizou JI,
Nijman SM.
Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701.
2015
Functional genomics to uncover drug mechanism of action.
Nijman SM.
Nat Chem Biol. 2015 Dec;11(12):942-8. doi: 10.1038/nchembio.1963. Epub 2015 Nov 17. Review.
2015
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
Licciardello MP,
Müllner MK,
Dürnberger G,
Kerzendorfer C,
Boidol B,
Trefzer C,
Sdelci S,
Berg T,
Penz T,
Schuster M,
Bock C,
Kralovics R,
Superti-Furga G,
Colinge J,
Nijman SM,
Kubicek S.
Oncogene. 2015 Jul;34(29):3780-90. doi: 10.1038/onc.2014.319. Epub 2014 Sep 29.
2015
Light-assisted small-molecule screening against protein kinases.
Inglés-Prieto Á,
Reichhart E,
Muellner MK,
Nowak M,
Nijman SM,
Grusch M,
Janovjak H.
Nat Chem Biol. 2015 Dec;11(12):952-4. doi: 10.1038/nchembio.1933. Epub 2015 Oct 12.
2015
A thesaurus of genetic variation for interrogation of repetitive genomic regions.
Kerzendorfer C,
Konopka T,
Nijman SM.
Nucleic Acids Res. 2015 May 26;43(10):e68. doi: 10.1093/nar/gkv178. Epub 2015 Mar 27.
2014
TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens.
Muellner MK,
Duernberger G,
Ganglberger F,
Kerzendorfer C,
Uras IZ,
Schoenegger A,
Bagienski K,
Colinge J,
Nijman SM.
BMC Bioinformatics. 2014 Apr 8;15:98. doi: 10.1186/1471-2105-15-98.
