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Year
Paper
2022

Imaging features facilitate diagnosis of porto-sinusoidal vascular disorder

Katharina Lampichler, Georg Semmler, Katharina Wöran, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, David Josef Maria Bauer, Lorenz Balcar, Lukas Burghart, Michael Trauner, Dietmar Tamandl, Ahmed Ba-Ssalamah, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner, Martina Scharitzer.
Eur Radiol. 2022 Sep 27. doi: 10.1007/s00330-022-09132-4. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36166087/
2022

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis

Jiří Reiniš, Oleksandr Petrenko, Benedikt Simbrunner, Benedikt S Hofer, Filippo Schepis, Marco Scoppettuolo, Dario Saltini, Federica Indulti, Tomas Guasconi, Agustin Albillos, Luis Téllez, Càndid Villanueva, Anna Brujats, Juan Carlos Garcia-Pagan, Valeria Perez-Campuzano, Virginia Hernández-Gea, Pierre-Emmanuel Rautou, Lucile Moga, Thomas Vanwolleghem, Wilhelmus J Kwanten, Sven Francque, Jonel Trebicka, Wenyi Gu, Philip G Ferstl, Lise Lotte Gluud, Flemming Bendtsen, Søren Møller, Stefan Kubicek, Mattias Mandorfer, Thomas Reiberger.
J Hepatol. 2022 Sep 21:S0168-8278(22)03119-1. doi: 10.1016/j.jhep.2022.09.012. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/36152767/
2022

Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease

Benedikt Simbrunner, Ida Falk Villesen, Philipp Königshofer, Bernhard Scheiner, David Bauer, Rafael Paternostro, Philipp Schwabl, Gerald Timelthaler, Dariga Ramazanova, Katharina Wöran, Judith Stift, Ernst Eigenbauer, Albert Friedrich Stättermayer, Rodrig Marculescu, Matthias Pinter, Søren Møller, Michael Trauner, Morten Karsdal, Diana Julie Leeming, Thomas Reiberger, Mattias Mandorfer.
Liver Int. 2022 Nov;42(11):2501-2512. doi: 10.1111/liv.15365. Epub 2022 Aug 25.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35822301/
2022

Angiopoietin 2 levels decrease after HCV-cure and reflect the evolution of portal hypertension

David Bauer, Karin Kozbial, Philipp Schwabl, David Chromy, Benedikt Simbrunner, Albert F Stättermayer, Matthias Pinter, Petra Steindl-Munda, Michael Trauner, Peter Ferenci, Thomas Reiberger, Mattias Mandorfer.
Dig Liver Dis. 2022 Sep;54(9):1222-1229. doi: 10.1016/j.dld.2022.02.013. Epub 2022 Apr 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35382974/
2022

Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension

Philipp Schwabl, Berit Anna Seeland, Florian Riedl, Tim Lukas Schubert, Philipp Königshofer, Ksenia Brusilovskaya, Oleksandr Petrenko, Benedikt Hofer, Ana-Iris Schiefer, Michael Trauner, Markus Peck-Radosavljevic, Thomas Reiberger.
Adv Med Sci. 2022 Mar;67(1):154-162. doi: 10.1016/j.advms.2022.02.005. Epub 2022 Mar 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35272246/
Year
Paper
2022
Simbrunner B, Villesen IF, Königshofer P, Scheiner B, Bauer D, Paternostro R, Schwabl P, Timelthaler G, Ramazanova D, Wöran K, Stift J, Eigenbauer E, Stättermayer AF, Marculescu R, Pinter M, Møller S, Trauner M, Karsdal M, Leeming DJ, Reiberger T, Mandorfer M. Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease. Liver Int. 2022 Jul 13. doi: 10.1111/liv.15365. Epub ahead of print. PMID: 35822301.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35822301/
2021
Balcar L, Semmler G, Pomej K, Simbrunner B, Bauer D, Hartl L, Jachs M, Paternostro R, Bucsics T, Pinter M, Trauner M, Mandorfer M, Reiberger T, Scheiner B. Patterns of acute decompensation in hospitalized patients with cirrhosis and course of acute-on-chronic liver failure. United European Gastroenterol J. 2021 May;9(4):427-437. doi: 10.1002/ueg2.12089.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34050619/
2021
Königshofer P, Brusilovskaya K, Petrenko O, Hofer BS, Schwabl P, Trauner M, Reiberger T. Nuclear receptors in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166235. doi: 10.1016/j.bbadis.2021.166235. Epub 2021 Jul 31.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34339839/
2022
Königshofer P, Hofer BS, Brusilovskaya K, Simbrunner B, Petrenko O, Wöran K, Herac M, Stift J, Lampichler K, Timelthaler G, Bauer D, Hartl L, Robl B, Sibila M, Podesser BK, Oberhuber G, Schwabl P, Mandorfer M, Trauner M, Reiberger T. Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies. Hepatology. 2022 Mar;75(3):610-622. doi: 10.1002/hep.32220. Epub 2021 Dec 20.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34716927/
2022
Schwabl P, Seeland BA, Riedl F, Schubert TL, Königshofer P, Brusilovskaya K, Petrenko O, Hofer B, Schiefer AI, Trauner M, Peck-Radosavljevic M, Reiberger T. Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension. Adv Med Sci. 2022 Mar;67(1):154-162. doi: 10.1016/j.advms.2022.02.005. Epub 2022 Mar 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/35272246/
2022
Burghart L, Halilbasic E, Schwabl P, Simbrunner B, Stättermayer AF, Petrenko O, Scheiner B, Bauer D, Pinter M, Boztug K, Mandorfer M, Trauner M, Reiberger T. Distinct prognostic value of different portal hypertension-associated features in patients with primary biliary cholangitis. J Gastroenterol. 2022 Feb;57(2):99-110. doi: 10.1007/s00535-021-01839-3. Epub 2021 Dec 11.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34893924/
2022
Wöran K, Semmler G, Jachs M, Simbrunner B, Bauer DJM, Binter T, Pomej K, Stättermayer AF, Schwabl P, Bucsics T, Paternostro R, Lampichler K, Pinter M, Trauner M, Mandorfer M, Stift J, Reiberger T, Scheiner B. Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension. Clin Gastroenterol Hepatol. 2022 Feb;20(2):e251-e266. doi: 10.1016/j.cgh.2020.11.039. Epub 2020 Dec 3.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33279774/
2022
Scheiner B, Pomej K, Kirstein MM, Hucke F, Finkelmeier F, Waidmann O, Himmelsbach V, Schulze K, von Felden J, Fründt TW, Stadler M, Heinzl H, Shmanko K, Spahn S, Radu P, Siebenhüner AR, Mertens JC, Rahbari NN, Kütting F, Waldschmidt DT, Ebert MP, Teufel A, De Dosso S, Pinato DJ, Pressiani T, Meischl T, Balcar L, Müller C, Mandorfer M, Reiberger T, Trauner M, Personeni N, Rimassa L, Bitzer M, Trojan J, Weinmann A, Wege H, Dufour JF, Peck-Radosavljevic M, Vogel A, Pinter M. Prognosis of patients with hepatocellular carcinoma treated with immunotherapy - development and validation of the CRAFITY score. J Hepatol. 2022 Feb;76(2):353-363. doi: 10.1016/j.jhep.2021.09.035. Epub 2021 Oct 12.
Abstract: https://pubmed.ncbi.nlm.nih.gov/34648895/
2021
Costa D, Simbrunner B, Jachs M, Hartl L, Bauer D, Paternostro R, Schwabl P, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T. Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality. J Hepatol. 2021 Apr;74(4):819-828. doi: 10.1016/j.jhep.2020.10.004. Epub 2020 Oct 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33075344/
2021
Schwabl P, Hambruch E, Budas GR, Supper P, Burnet M, Liles JT, Birkel M, Brusilovskaya K, Königshofer P, Peck-Radosavljevic M, Watkins WJ, Trauner M, Breckenridge DG, Kremoser C, Reiberger T. The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model. Biomedicines. 2021 Jan 9;9(1):60. doi: 10.3390/biomedicines9010060.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33435509/
2021
Costa D, Simbrunner B, Reiberger T. Reply to: "Prognostic role of systemic inflammatory biomarkers in advanced chronic liver disease". J Hepatol. 2021 Apr;74(4):1000-1001. doi: 10.1016/j.jhep.2021.01.026. Epub 2021 Jan 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33497763/
2021
Simbrunner B, Costa D, Reiberger T. Reply to: "Presepsin as a biomarker of inflammation and prognosis in decompensated liver disease". J Hepatol. 2021 Apr 20:S0168-8278(21)00233-6. doi: 10.1016/j.jhep.2021.03.027. Online ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33852949/
2020
Simbrunner B, Marculescu R, Scheiner B, Schwabl P, Bucsics T, Stadlmann A, Bauer DJM, Paternostro R, Eigenbauer E, Pinter M, Stättermayer AF, Trauner M, Mandorfer M, Reiberger T. Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease. Liver Int. 2020 Jul;40(7):1713-1724. doi: 10.1111/liv.14498. Epub 2020 May 18.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32358998/
2020
Brusilovskaya K, Königshofer P, Lampach D, Szodl A, Supper P, Bauer D, Beer A, Stift J, Timelthaler G, Oberhuber G, Podesser BK, Seif M, Zinober K, Rohr-Udilova N, Trauner M, Reiberger T, Schwabl P. Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct-ligated rats. United European Gastroenterol J. 2020 Dec;8(10):1174-1185. doi: 10.1177/2050640620944140. Epub 2020 Sep 2.
Abstract: https://pubmed.ncbi.nlm.nih.gov/32878579/
2020
Costa D, Simbrunner B, Jachs M, Hartl L, Bauer D, Paternostro R, Schwabl P, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T. Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality. J Hepatol. 2021 Apr;74(4):819-828. doi: 10.1016/j.jhep.2020.10.004. Epub 2020 Oct 16.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33075344/
2020
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A. PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Rep. 2020 Dec 3;21(12):e50893. doi: 10.15252/embr.202050893. Epub 2020 Nov 23.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33225610/
2020
Simbrunner B, Semmler G, Stadlmann A, Scheiner B, Schwabl P, Paternostro R, Bucsics T, Bauer D, Eigenbauer E, Pinter M, Stättermayer AF, Quehenberger P, Marculescu R, Trauner M, Mandorfer M, Reiberger T. Vitamin A levels reflect disease severity and portal hypertension in patients with cirrhosis. Hepatol Int. 2020 Dec;14(6):1093-1103. doi: 10.1007/s12072-020-10112-3. Epub 2020 Dec 8.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33289910/
2020
Wöran K, Semmler G, Jachs M, Simbrunner B, Maria Bauer DJ, Binter T, Pomej K, Stättermayer AF, Schwabl P, Bucsics T, Paternostro R, Lampichler K, Pinter M, Trauner M, Mandorfer M, Stift J, Reiberger T, Scheiner B. Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension. Clin Gastroenterol Hepatol. 2020 Dec 3:S1542-3565(20)31629-3. doi: 10.1016/j.cgh.2020.11.039. Epub ahead of print.
Abstract: https://pubmed.ncbi.nlm.nih.gov/33279774/
2020
Paternostro R, Pfeiffenberger J, Ferenci P, Stättermayer AF, Stauber RE, Wrba F, Longerich T, Lackner K, Trauner M, Ferlitsch A, Reiberger T, Weiss KH. Non-invasive diagnosis of cirrhosis and long-term disease monitoring by transient elastography in patients with Wilson disease. Liver Int. 2020 Apr;40(4):894-904. doi: 10.1111/liv.14368. Epub 2020 Jan 22.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31898387
2020
Brunner SB, Marculescu R, Scheiner B, Schwabl P, Bucsics T, Stadlmann A, Bauer DJM, Paternostro R, Eigenbauer E, Pinter M, Stättermayer AF, Trauner M, Mandorfer M, Reiberger T. Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease. Liver Int. 2020 May 2. doi: 10.1111/liv.14498. Epub ahead of print.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/32358998
2019
Semmler G, Simbrunner B, Scheiner B, Schwabl P, Paternostro R, Bucsics T,Stättermayer AF, Bauer D, Pinter M, Ferenci P, Trauner M, Mandorfer M, Reiberger T. Impact of farnesoid X receptor single nucleotide polymorphisms on hepatic decompensation and mortality in cirrhotic patients with portal hypertension. JGastroenterol Hepatol. 2019 May 6. doi: 10.1111/jgh.14700. [Epub ahead of print]
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/31062417