Publications
2025
Targeted protein degradation for cancer therapy
Matthias Hinterndorfer,
Valentina A Spiteri,
Alessio Ciulli,
Georg E Winter.
Nat Rev Cancer. 2025 Apr 25. doi: 10.1038/s41568-025-00817-8. Online ahead of print.
2024
Thoughts for the future
Lona M Alkhalaf,
Cheryl Arrowsmith,
Emily P Balskus,
Giovanna Bergamini,
Rashna Bhandari,
Christopher J Chang,
Peng Chen,
Xing Chen,
Alessio Ciulli,
Julia A Cricco,
Benjamin G Davis,
Martina Delbianco,
Natalia Dudareva,
Erin Dueber,
Fleur Ferguson,
Priscila Oliveira de Giuseppe,
Itaru Hamachi,
Ming Chen Hammond,
Stavroula K Hatzios,
Won Do Heo,
Jon Paul Janet,
Siddhesh S Kamat,
Stefan Knapp,
Yamuna Krishnan,
Kathrin Lang,
Luca Laraia,
Reuben B Leveson-Gower,
Xiang David Li,
David R Liu,
Mo-Fang Liu,
Nir London,
Nilkamal Mahanta,
Cristina Mayor-Ruiz,
Tom Muir,
Mário Tyago Murakami,
Hyun-Woo Rhee,
Matt Robers,
Alex Satz,
Brenda A Schulman,
Ben Shen,
Brian Shoichet,
Erick Strauss,
Tsutomu Suzuki,
Pratyush Tiwary,
Herbert Waldmann,
Thomas R Ward,
Amy Weeks,
Eranthie Weerapana,
Georg Winter.
Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2.
2024
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera
Adam G Bond,
Miquel Muñoz I Ordoño,
Celia M Bisbach,
Conner Craigon,
Nikolai Makukhin,
Elizabeth A Caine,
Manjula Nagala,
Marjeta Urh,
Georg E Winter,
Kristin M Riching,
Alessio Ciulli.
J Am Chem Soc. 2024 Dec 11;146(49):33675-33711. doi: 10.1021/jacs.4c11556. Epub 2024 Nov 28.
2024
Degradome analysis to identify direct protein substrates of small-molecule degraders
Marco Jochem,
Anna Schrempf,
Lina-Marie Wagner,
Dmitri Segal,
Jose Cisneros,
Amanda Ng,
Georg E Winter,
Jeroen Krijgsveld.
Cell Chem Biol. 2025 Jan 16;32(1):192-200.e6. doi: 10.1016/j.chembiol.2024.10.007. Epub 2024 Nov 12.
2024
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs
Georg E Winter.
ACS Chem Biol. 2024 Oct 18;19(10):2089-2102. doi: 10.1021/acschembio.4c00191. Epub 2024 Sep 12.
2024
Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3
Elisabeth Hennes,
Belén Lucas,
Natalie S Scholes,
Xiu-Fen Cheng,
Daniel C Scott,
Matthias Bischoff,
Katharina Reich,
Raphael Gasper,
María Lucas,
Teng Teng Xu,
Lisa-Marie Pulvermacher,
Lara Dötsch,
Hana Imrichova,
Alexandra Brause,
Kesava Reddy Naredla,
Sonja Sievers,
Kamal Kumar,
Petra Janning,
Malte Gersch,
Peter J Murray,
Brenda A Schulman,
Georg E Winter,
Slava Ziegler,
Herbert Waldmann.
bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857. doi: 10.1101/2024.07.10.602857.
2024
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
Chrysanthi Kagiou,
Jose A Cisneros,
Jakob Farnung,
Joanna Liwocha,
Fabian Offensperger,
Kevin Dong,
Ka Yang,
Gary Tin,
Christina S Horstmann,
Matthias Hinterndorfer,
Joao A Paulo,
Natalie S Scholes,
Juan Sanchez Avila,
Michaela Fellner,
Florian Andersch,
J Thomas Hannich,
Johannes Zuber,
Stefan Kubicek,
Steven P Gygi,
Brenda A Schulman,
Georg E Winter.
Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3.
2024
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Nianzhe He,
Laura Depta,
Cecilia Rossetti,
Lucie Caramelle,
Marko Cigler,
Hogan P Bryce-Rogers,
Marine Michon,
Oliver Rafn Dan,
Joseph Hoock,
Julien Barbier,
Daniel Gillet,
Alison Forrester,
Georg E Winter,
Luca Laraia.
Nat Chem Biol. 2025 Feb;21(2):203-214. doi: 10.1038/s41589-024-01653-x. Epub 2024 Jun 21.
2024
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Marko Cigler,
Hana Imrichova,
Fabian Frommelt,
Lucie Caramelle,
Laura Depta,
Andrea Rukavina,
Chrysanthi Kagiou,
J Thomas Hannich,
Cristina Mayor-Ruiz,
Giulio Superti-Furga,
Sonja Sievers,
Alison Forrester,
Luca Laraia,
Herbert Waldmann,
Georg E Winter.
Nat Chem Biol. 2025 Feb;21(2):193-202. doi: 10.1038/s41589-024-01614-4. Epub 2024 Jun 21.
2024
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins
Gary Tin,
Marko Cigler,
Matthias Hinterndorfer,
Kevin D Dong,
Hana Imrichova,
Steven P Gygi,
Georg E Winter.
Bioorg Med Chem Lett. 2024 Jul 15;107:129779. doi: 10.1016/j.bmcl.2024.129779. Epub 2024 May 9.
