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UID:20-287@cemm.at
CLASS: PUBLIC
SUMMARY:Where babies come from: The invisible storyline of development, fro
 m zygote to newborn
DESCRIPTION:CeMM Landsteiner Lecture 2026\n\nRegistration is open until May
  4. Please register using the registration button on the right (desktop) or
  below (mobile).\n\nAbout the lectureHow does a single-cell zygote transfor
 m into a complex, free-living newborn composed of over 500 million cells in
  just three weeks?\n\nJoin us for the 2026 CeMM Landsteiner Lecture as Jay 
 Shendure (University of Washington) explores the frontiers of developmental
  biology. Professor Shendure will detail his lab’s pioneering efforts to re
 construct the entirety of mouse development at single-cell resolution using
  two revolutionary strategies.\n\nThe house mouse is an exceptional model s
 ystem in biology and medicine, combining powerful genetic tractability with
  close evolutionary affinity to humans. Mouse pregnancy lasts only three we
 eks, during which its genome orchestrates the astonishing transformation of
  a single-cell zygote into a free-living newborn composed of more than 500 
 million cells.\n\nJay Shendure says: "In this lecture, I will describe our 
 ongoing efforts to reconstruct the entirety of mouse development at single-
 cell resolution using two complementary strategies. First, we analyze whole
  embryos at many different stages of development and measure the molecular 
 state of individual cells. These high-resolution “snapshots” are then assem
 bled computationally into a continuous time-lapse movie of development. Sec
 ond, we use a method called “molecular recording”, in which living cells be
 come their own historians by writing information about molecular events dur
 ing their development directly into their DNA. This allows us to reconstruc
 t genetic family trees of cells and trace how different tissues and organs 
 arise.\n\nFinally, I will argue that model organisms remain indispensable i
 n the age of AI, and that evolutionary transfer learning at the scale of th
 e whole organism may represent our best path toward predictive models of hu
 man development, health, and disease."\n\nAbout the speaker:Jay Shendure, M
 D, PhD, is an Investigator of the Howard Hughes Medical Institute, a Profes
 sor of Genome Sciences at the University of Washington, and Scientific Dire
 ctor of the Seattle Hub for Synthetic Biology and the Brotman Baty Institut
 e for Precision Medicine. His 2005 doctoral thesis with George Church inclu
 ded one of the first successful reductions to practice of next-generation D
 NA sequencing.\n\nDr. Shendure’s laboratory pioneered exome sequencing and 
 its earliest applications to gene discovery for Mendelian disorders and aut
 ism; cell-free DNA diagnostics for cancer and reproductive medicine; massiv
 ely parallel reporter assays; saturation genome editing; combinatorial sing
 le-cell molecular profiling; and longitudinal molecular recording.\n\nHe is
  an elected member of the US National Academy of Sciences, the US National 
 Academy of Medicine, and the American Association for the Advancement of Sc
 ience. He is also a recipient of the Richard Lounsbery Award from the US Na
 tional Academy of Sciences, the Mendel Award from the European Society of H
 uman Genetics, and the Curt Stern Award from the American Society of Human 
 Genetics. Dr. Shendure received his BA from Princeton University (1996) and
  his MD and PhD degrees from Harvard Medical School (2007).
LOCATION:Festive Hall, ÖAW
DTSTAMP:20260309T124857Z
DTSTART:20260511T160000Z
DTEND:20260511T190000Z
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