CeMM focuses on human biology and disease related to cancer, inflammation/immune disorders and has established a strategic interest in blood and in personalized medicine.

Research Modes and Paradigm

At CeMM, the traditional paradigm of basic research finding applications through a long Darwinian evolutionary process is challenged by a more integrative and systems-level approach, according to which different areas of expertise are involved from the beginning to cooperate on medically-relevant themes. Project leaders access the necessary multidisciplinary expertise from the modular participation of other laboratories. Emphasis is given to the understanding of patho-biology at the molecular level and all projects that receive support towards potential therapeutic and diagnostic development need to be understood at the mechanistic level. In general, CeMM is interested in the mode-of-action of pathologically-relevant proteins and novel or existing drugs. Pathological processes are linked via an interdisciplinary systems-biology strategy. This systems-biology strategy encompasses modern genomic methods including proteomics, chemical biology, biological-chip technologies, next-generation sequencing and bioinformatics to derive models with predictive value that can be tested.

Research Groups and Research Organization

The new paradigm according to which research groups at CeMM operate is optimized to maximize the synergy between groups to empower small labs to tackle great questions and the integration with medicine and clinical needs. Thus each group is independent and responsible for its own competence and technical expertise in key areas at an international competitive level. At the same time, each group is motivated to work on trans-group CeMM-wide strategic collaborative projects.