YearPaper
2014 Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24695225
2014 DNA replication stress: Causes, resolution and disease.Mazouzi A, Velimezi G, Loizou JI.Exp Cell Res. 2014 Sep 30. pii: S0014-4827(14)00435-2. doi: 10.1016/j.yexcr.2014.09.030. [Epub ahead of print] Review.PMID: 25281304.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25281304
2014 ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, Loizou JI. DNA Repair (Amst). 2014 Sep 24. pii: S1568-7864(14)00223-7. doi: 10.1016/j.dnarep.2014.09.001. [Epub ahead of print] PMID: 25262557.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25262557
2015 Prochazkova J, Loizou JI. Programmed DNA breaks in lymphoid cells: Repair mechanisms and consequences in human disease. Immunology. 2015 Oct 12. doi: 10.1111/imm.12547.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26455503
2015 Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, Moder M, Turchinovich G, Hladik A, Gurnhofer E, Hayday A, Behrens A, Knapp S, Kenner L, Ellmeier W, Loizou JI. DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS Genet. 2015 Nov 6;11(11):e1005645. doi: 10.1371/journal.pgen.1005645. eCollection 2015.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/26544571
2016 Anjos-Afonso F, Loizou JI, Bradburn A, Kanu N, Purewal S, Da Costa C, Bonnet D, Behrens A. Perturbed hematopoiesis in mice lacking ATMIN. Blood 2016 Sep. doi:10.1182/blood-2015-09-672980.
Abstract: http://www.bloodjournal.org/content/early/2016/08/31/blood-2015-09-67298
2016 Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou & Sebastian M. B. Nijman. MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated. Nature Communications 2016 Dec 6. doi:10.1038/NCOMMS13701
Abstract: http://www.nature.com/articles/ncomms13701
2016 Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI. A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Rep. 2016 Apr 14. pii: S2211-1247(16)30366-7. doi: 10.1016/j.celrep.2016.03.077.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27149854
2017 Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29089570
2017 Mazouzi A, Battistini F, Moser SC, Ferreira da Silva J, Wiedner M, Owusu M, Lardeau CH, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JI. Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. Mol Cell. 2017 Nov 16;68(4):797-807.e7. doi: 10.1016/j.molcel.2017.10.021
Abstract: http://www.cell.com/molecular-cell/comments/S1097-2765(17)30796-7