Head, Chemical Screening and Platform Austria for Chemical Biology (PLACEBO)
Head, Proteomics and Metabolomics Facility

Stefan Kubicek
Chemical Screening, Proteomics and Metabolomics Facility

 

 

Platform Austria for Chemical Biology (PLACEBO)

PLACEBO was initiated as a partnership between CeMM and seven other Austrian research groups, funded under the Gen-AU program of the Austrian Ministry of Science and Research. The project has developed into a long-term initiative open to the wider scientific community on a collaborative basis.

PLACEBO provides researchers in Austria with access to chemical biology resources including a 92,000 compound library, high-throughput and high-content screening and chemical proteomics to identify and characterize small molecules that affect new targets for studying biological processes and developing new drugs.

Mass spectrometry

CeMM offers a world-class mass spectrometry and proteomics department with technical and bioinformatics expertise. Due to the critical nature of the mass spectrometry, the facility has been designed to the highest standards with individual cubicles per machine, maintaining a constant temperature with minimal variation. The HVAC (Heating, Ventilation and Cooling) system runs with N+1 redundancy to maintain operation at all times and the room layouts are also designed to reduce noise and vibrations. The machines run 24/7.

  • Protein-protein interactions to generate comprehensive protein interactomes.
  • Drug-protein interactions.
  • Quantitative expression proteomics for the relative and comparative quantitative analysis of global proteomes.
  • Monitoring the role of post-translational modifications in cell signalling pathways.