With great pleasure we announce that Denise Barlow, Principal Investigator at CeMM and Honorary Professor of Genetics at the University of Vienna, has received the Erwin Schrödinger Prize 2014 for lifetime achievements. The Erwin Schrödinger Prize is an annual award presented by the Austrian Academy of Sciences for lifetime achievement in the fields of mathematics and natural sciences. This prize is the most prestigious award of the Austrian Academy of Sciences and was established in 1958.
This recognition is very well-deserved. Denise Barlow's contributions to the field of mammalian genetics as well as to Austrian research are exceptional. She is a world-leading expert in epigenetic mechanisms operating in development and disease. We congratulate Denise!
In 1991, the Barlow group discovered the first mammalian imprinted gene (Igf2r) and since then, has uncovered many details of the imprinting mechanism and promoted its use as an epigenetic gene-regulatory model. Her laboratory has shown that an unusual and very long non-coding RNA (lncRNA), a macro ncRNA, induces imprinted gene expression. More recently, her laboratory has also shown that transcription, independent of the lncRNA product, is the mechanisms that silences the Igf2r gene. The focus of her work currently is to understand the epigenetic processes by which these unusual macro-ncRNAs induce gene silencing in imprinted clusters and in the wider mouse and human genomes.
July 06 - 08, 2014 More than 40 speakers, session chairs and special guests together with guests representing the Austrian molecular biology and life sciences community celebrated the 50th and 40th anniversaries of the European Molecular Biology Organization (EMBO) and the European Molecular Biology Laboratory (EMBL) and their impact in Austria, with a dedicated event. EMBanniversary AUSTRIA, a unique fusion of a scientific conference, alumni reunion, party as well as science & society and political stakeholder event, started with a Sunday evening Welcome Bash on the terrace of the CeMM – Research Center for Molecular Medicine on July 6, followed by a two-day conference in the beautiful Jesuitensaal of the Aula der Wissenschaften in Vienna’s 1st district.
The conference included 7 scientific sessions, thematically named after eminent Austrian scientists such as Gödel, Landsteiner, Perutz or Mendel, with speakers and session chairs that have direct links to EMBO and EMBL, either through past employment, prizes or fellowships and that furthermore also have a direct link to Austria. EMBL Director General Iain Mattaj delivered the Wittgenstein Lecture entitled “Looking into the future of molecular biology through the EMBL lens”. A second special lecture, the Freud Lecture, was delivered by the IMP’s former director Kim Nasmyth of the University of Oxford.
Giulio Superti-Furga, Chair of the Board of the EMBL Alumni Association, on behalf of the association’s Austrian Chapter, presented the association’s Austrian Chapter Achievement Award Medal to Max L. Birnstiel, former director of the Institute of Molecular Pathology, and Denise P. Barlow, Principal Investigator at CeMM in recognition of a life-time of outstanding research in molecular biology and for their contributions to the EMBO and EMBL community in Austria.
The award ceremony was followed by a lively round table panel discussion on “How to Promote Molecular Biology?” chaired by Giulio Superti-Furga. The panelists Maria Leptin (EMBO Director), Hemma Bauer (Austrian Ministry of Science, Research and Economy) and Renée Schröder (Max F. Perutz Laboratories, Vienna) inspired, challenged and engaged the audience in a vibrant debate about the role, impact and future of molecular biology and the significant role of life sciences research in Austria.
EMBanniversary AUSTRIA was rounded up by a wine and cheese reception that provided additional opportunity for video interviews, networking and reminiscence. Many guests expressed their excitement with respect to the opportunity to meeting old friends and hearing cutting-edge science from Austrians involved in the diverse areas of the life sciences field. We thank all speakers and participants for their contribution to a successful and enjoyable event.
We gratefully acknowledge the following sponsors for providing additional support for EMBanniversary AUSTRIA: EMBL Alumni Association, EMBLEM Technology Transfer GmbH, Austrian Federal Ministry of Science, Research and Economy, Research Institute of Molecular Pathology, Austrian Academy of Sciences, Boehringer Ingelheim RCV GmbH & Co KG, Haplogen GmbH, Starlab GmbH, Max F. Perutz Laboratories, Sigma-Aldrich Handels GmbH and Biozym.
Happy birthday EMBO! Happy birthday EMBL!
The Austrian Academy of Sciences (ÖAW) has announced their newly elected members. Among them are two Principal Investigators of CeMM. We congratulate Sylvia Knapp for being elected as Corresponding Member and Sebastian Nijman for having been named as member of the Chapter of Young Scientists (“Junge Kurie”). Giulio Superti-Furga, Scientific Director of CeMM: “We are very proud of the scientific excellence of the two group leaders. This recognition by the Austrian Academy of Sciences is very well-deserved.”
The 8th CeMM Karl Landsteiner Lecture at the beautifully frescoed Festive Hall of the Austrian Academy of Sciences was delivered by Prof. David M. Sabatini of the Whitehead Institute for Biomedical Research of the Massachusetts Institute of Technology (MIT). More than 350 scientists and interested lay people from all walks of society attended the lecture, which was opened by CeMM’s Scientific Director Prof. Giulio Superti-Furga, who acknowledged Prof. Sabatini’s distinguished achievements and leading contribution to molecular biology. Gustav Ammerer, a Viennese biotech pioneer, research group leader at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and accomplished amateur cello player provided a smooth start of the evening with his interpretations of Johann Sebastian Bach’s Suite No.1 in G major (BWV 1007), Allemande & Sarabande. David M. Sabatini continued the series of world-leading distinguished scientists of CeMM Karl Landsteiner lecturers that started in 2007. Prof. Sabatini, MD, PhD, recipient of the 2014 National Academy of Sciences Award in Molecular Biology, is the leading investigator on what can be considered probably the most “critical” biological process, the regulation of cellular growth and metabolic state, and its master regulator protein “mTOR” with its essential role in cellular decision making. In his talk “Grow – Shrink, Get Fat – Stay Lean, Divide – Rest: How Cells Decide” Prof. Sabatini outlined the fundamental and intriguing processes surrounding the mTOR protein that cells use to integrate internal and environmental cues such as nutrient availability to rationalize cellular decision making such as proliferation or differentiation. In his presentation he also introduced some of his latest research findings and discussed challenging open questions. The lecture was very well perceived as evidenced by a lively podium discussion and rounded up by a cocktail reception in the academy’s aula. We are grateful to Prof. Sabatini for his fascinating presentation.
Mutations of CALR have been discovered recently in an estimated 15% of cases of myeloproliferative neoplasms (MPNs - a group of blood disorders involving overproduction of blood cells) by the research team of Robert Kralovics at CeMM and collaboration partners at the Medical University of Vienna (NEJM doi: 10.1056/NEJMoa1311347). QIAGEN now licensed the technology from CeMM, and will develop a reliable diagnostic test for the CALR mutations offering each patient a clearer prognostic profile and guiding disease management. Development of a CALR diagnostic test will be highly complementary to QIAGEN’s kits for a key mutation of the Janus kinase 2 (JAK2) gene.
Lange Nacht der Forschung (Long Night of Science) 2014
(Vienna, 4 April 2014) Counting more than 135.000 visitors of all ages the ‘Lange Nacht der Forschung’ (Long Night of Science) 2014, a joint initiative of the Federal Ministry of Science, Research and Economy (BMWFW) and the Federal Ministry for Transport, Innovation and Technology (BMVIT), took place on Friday 4th April, at several locations throughout Austria. CeMM´s booth at the Aula der Wissenschaften in Vienna’s first district with about 3.200 visitors was a significant success. CeMM was represented with an information stand that also included a ‘hands-on’ science parcours with stations that allowed visitors to extract DNA from strawberries, learn how to build a DNA double helix with gummi bears and toothpicks, a pipetting competition and a microscopy station. The CeMM Management and CeMM scientists, among them Principal Investigators Joanna Loizou, Andreas Bergthaler, Kaan Boztug and Christoph Bock were present on site and excited by the overwhelming interest. “The last teenagers, who still wanted to look through the microscope, literally had to be politely rejected at 10 past midnight – what a night, what a sight!”, Bergthaler summed up. Last but not least the good news of the evening rounded up the successful event, when the Federal Minister for Science, Research and Economy, Reinhold Mitterlehner, announced that basic science in Austria is not threatened by budget cuts.
New drug prevents tumour growth by inhibiting the nucleotide sanitizing enzyme MTH1
(Vienna, 2 April 2014) A ground-breaking study spearheaded by Scientific Director Giulio Superti-Furga at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences shows that fast-growing cancer cells are sensitive towards imbalances in the metabolism of nucleotides, the building blocks of DNA. This vulnerability can be exploited for a radically novel antitumour therapeutic approach. Not only did the researchers from Vienna, in a joint effort with colleagues from Oxford and Stockholm, identify the enzyme MTH1 as an Achilles heel of malignant tumour cells, but also, in a wonderful twist of fate, they discovered the chemical mirror image of an existing anti-cancer drug called crizotinib to be an efficient inhibitor of MTH1 activity. The study was published in advance online by the renowned scientific journal Nature on 2nd April 2014. (read more)
Herbert Gottweis, Professor at the University of Vienna and former Vice President of the Austrian Science Fund died prematurely on Monday, March 31, at the age of 56. We express our deepest condolences to his family and colleagues. We thank Herbert Gottweis for his professional and collegial support, and the great conversations we were privileged to hold on policy studies, the understanding of biomedical and healthcare transformation, and creativity in science. We will always remember his participation at the CeMM Retreat in 2012.
Prof. Gian Domenico Borasio, M.D, Centre Hospitalier Universitaire Vaudois and University of Lausanne, gave the 3rd SMART lecture, on March 28th, 2014 at CeMM. Numerous scientists, clinicians and interested lay people witnessed a fascinating and thought-provoking lecture on “Empathy and Evidence – The Scientific Foundations of Palliative Medicine” followed by a lively forum discussion. Dr. Borasio, who is a leader in the science and implementation of modern palliative medicine started his talk by acknowledging the pioneering work of Dame Cicely Saunders followed by a detailed discussion of fundamental questions and concepts of ‘quality of life’ and ‘personal values’ and concluded with an outlook on the many barriers that still need to be overcome towards a general implementation of a palliative approach for a more sustainable healthcare system of the future. We thank Gian Domenico Borasio for his inspiring presentation.